Ecological geneticsEcological geneticsЭкологическая генетика1811-09322411-9202Eco-Vector575310.17816/ecogen10151-61ArticlesСтатьиResearch ArticleGenetic study of motor functions in Drosophila melanogasterГЕНЕТИЧЕСКОЕ ИССЛЕДОВАНИЕ МОТОРНЫХ ФУНКЦИЙ DROSOPHILA MELANOGASTERFedotovSergey AФедотовСергей Александровичserg900@yandex.ruBraginaJulia VБрагинаЮлия Валерьевнаjulia_bragina@mail.ruBesedinaNataliya GБесединаНаталья Геннадьевнаmolotova@pavlov.infran.ruDanilenkovaLarisa VДаниленковаЛариса Владимировнаnkam@pavlov.infran.ruKamyshevaElena AКамышеваЕлена Аркадьевнаnkam@pavlov.infran.ruKamyshevNikolay GКамышевНиколай Григорьевичnkam@pavlov.infran.ruI.P. Pavlov Institute of Physiology, RAS, Saint-Petersburg, RFИнститут Физиологии им. И. П. Павлова РАН, Санкт-Петербург, РФ15032012101VOL 10, NO1 (2012)ТОМ 10, №1 (2012)516118112016Copyright ©; 2012, Fedotov S.A., Bragina J.V., Besedina N.G., Danilenkova L.V., Kamysheva E.A., Kamyshev N.G.Copyright ©; 2012, Федотов С.А., Брагина Ю.В., Беседина Н.Г., Даниленкова Л.В., Камышева Е.А., Камышев Н.Г.2012Fedotov S.A., Bragina J.V., Besedina N.G., Danilenkova L.V., Kamysheva E.A., Kamyshev N.G.Федотов С.А., Брагина Ю.В., Беседина Н.Г., Даниленкова Л.В., Камышева Е.А., Камышев Н.Г.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/ecolgenet/article/view/5753

To investigate molecular mechanisms of central pattern generators (CPG s) functioning, we carried out a screening of collection of Drosophila P-insertional mutants for strong deviations in locomotion and courtship song. In 21 mutants, the site of the P-insertion was localized by sequencing of the fragments of genomic DNA flanking the P-element. Bioinformational analysis revealed a list of candidate genes, potential players in development and functioning of CPG s. Possible involvement of certain identified genes in rhythmic motor activity is suggested for the first time (CG15630, Map205).

Для исследования молекулярных механизмов функционирования центральных генераторов моторного паттерна (ЦГМП ) проведен скрининг коллекции Р-инсерционных мутантов дрозофилы на сильные отклонения в локомоции и песне ухаживания. У 21 мутанта был установлен сайт инсерции P-элемента в геноме путем секвенирования фланговых последовательностей геномной ДНК. Биоинформационный анализ позволил определить группу генов- кандидатов, возможных участников развития и функционирования ЦГМП. Для некоторых из выявленных генов возможность участия в ритмических моторных актах предполагается впервые (CG 15630, Map205).

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