Ecological geneticsEcological geneticsЭкологическая генетика1811-09322411-9202Eco-Vector696210.17816/ecogen15452-59Genetic educationСистема генетического образованияReview ArticleThe role of archaea in the origin of eukaryotesРоль архей в происхождении эукариотShestakovSergey V.ШестаковСергей Васильевич
Russian Federation

dr. biol. sciences, professor, main researcher

доктор биологических наук, профессор, академик РАН, главный научный сотрудник

shestakovgen@mail.ruN. Vavilov Institute of General Genetics, RASФГБУН «Институт общей генетики им. Н.И. Вавилова» РАН2512201715452590409201712112017Copyright ©; 2017, Shestakov S.V.Copyright ©; 2017, Шестаков С.В.2017Shestakov S.V.Шестаков С.В.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/ecolgenet/article/view/6962

A key role of particular evolutionary branch of archaea in the emergence of eukaryotic cell is considered on the basis of phylogenomics. Genomes of recently discovered uncultivated proteoarchaea belonging to Lokiarchaea and Asgard-group contain a large sets of eukaryotic-like genes. This allows to suggest that ancient forms of such archaean could participate in symbiotic fusion with bacteria serving as a mitochondrial progenitor. The open questions concerning properties of LECA (so-called last eukaryotic common ancestor) are discussed in the frame of endosymbiotic hypothesis of eukaryogenesis.

В обзоре с позиций филогеномики рассмотрена ключевая роль определенной эволюционной ветви архей в происхождении клетки эукариот. Геномы недавно открытых некультивируемых протеоархей Lokiarchaea и Asgard-группы содержат большие наборы генов, сходных с эукариотическими. Это позволило предположить, что родственные таким группам древние археи могли участвовать в симбиотическом слиянии с бактериями — предшественниками митохондрий. В рамках эндосимбиотической гипотезы эукариогенеза обсуждены открытые вопросы о свойствах LECA (так называемого последнего эукариотического общего предка).

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