Vol 7, No 4 (2016)

The study focuses on modern and innovative methods of surgical treatment of hemorrhoidal disease. The results of using diode laser in the treatment of this disease showed some effectiveness and potential of this methodology. Identified key indications for the use of the diode laser, the technique of execution, revealed its advantages over traditional methods of surgical treatment.

Oxidative stress, which is observed in patients with coronary artery disease (CAD), is accompanied by the changes of plasma redox regulation. We aimed to investigate the dynamics of blood oxygen uptake rates in patients with CAD following coronary artery bypass graft surgery. We examined 80 CAD patients at admission to the hospital, discharge and 6 months after surgery. Patients were divided into three groups: Group 1 - 8 patients with acute coronary syndrome (ACS), Group 2 - 61 patients with old myocardial infarction (old MI), Group 3 - 11 patients with chronic CAD (CCAD). 24 healthy donors were included in the control group. We modelled the processes of lipid peroxidation (LPO) in plasma using biological oxygen monitor. The increase of indicators of blood oxygen uptake was registered in ACS and old MI patients at the day of admission, old MI patients at the day of discharge from the hospital, and CCАD patients at the day of 6 months after surgery. The increase of these indicators occurred after the depletion of blood antioxidant systems and caused by activation of lipoprotein peroxidation on the minute 30 and the decline of lipid radicals formation on the minute 40. As the plasma antioxidant status was greater, the оxidative damage of lipids started on the minute 40 of the study.

Cervical pregnancy is a currently important medical and social problem, characterized by relatively high mortality and often leads to a loss of fertility in women of reproductive age. This clinical case demonstrates a possible approach of conservative therapy in conditions of excessive bleeding in women interested in the reservation of reproductive function, using high-tech minimally invasive methods of treatment in combination with chemotherapy.

Presents an overview of russian and foreign publications, devoted to contemporary methods of conservative and surgical treatment of acute inflammation of the epithelial pilonidal sinus. Details of surgical interventions, techniques, indications and contraindications. Special attention is paid to pre-operative preparation for surgery, wound closure after surgical access, patient management in the postoperative period.

Understanding the structure of the biological membrane and its role in the cell has evolved significantly since the introduction of the classical fluid mosaic model by Singer and Nicholson. Later fluid mosaic model has been redesigned, expanded and has become considerably complicated. It has been experimentally proved that the membrane consists of so-called rafts, which are functional “islands” with the specific lipid composition with proteins. Lipid rafts play a central role in many cellular processes, including barrier functions, membrane polarization and the cell signaling. Several groups of pathogens, bacteria, prions, viruses, parasites use lipid rafts for their purposes. Rafts always occur on both sides of the membrane opposite to each other, but the nature of the two-layer rafts are still poorly understood. Previously it was theoretically calculated that the shift of the monolayers in raft occurs, which reduces the mechanical energy of the boundaries, and ultimately leads to a bilayer structure of the raft. In this study with the help of computer modeling we study the energy of interaction between two monolayers of the raft in order to test the hypothesis about their relative shift.