Journal of obstetrics and women's diseasesJournal of obstetrics and women's diseases1684-04611683-9366Eco-Vector124410.17816/JOWD64176-82Research ArticleSystemic Enzyme Therapy during expectant management of preeclampsia: controlled randomised trialRepinaMargarita AleksandrovnaprofessorMargarita.Safronova@szgmu.ruKorzoTat’yana MarkovnaphysicianMargarita.Safronova@szgmu.ruNorth-Western State Medical University named after I. I. MechnikovMaternity hospital N 615012015641768215012015Copyright © 2015, Repina M.A., Korzo T.M.2015Systemic Enzyme Therapy (medicine Wobenzym) or standard therapy randomly allocated of pregnant women with mild preeclampsia. Outcome for mothers and fetus, mechanism of action discussed.systemic enzyme therapySETpregnancypreeclampsiaplateletsсистемная энзимотерапияСЭТбеременностьпреэклампсиятромбоциты[Репина М. А., Корзо Т. М., Папаян Л. П., Красовская Г. А, Сумская Г. Ф. Современные подходы к коррекции нарушений гемостаза при беременности, осложненной гестозом. СПб.; 1998][Шитикова А. С., Каргин В. Д., Белязо О. Е. и др. Морфологическая оценка повышенной внутрисосудистой активации тромбоцитов. Методич. реком. СПб.; 1996][Askie L. M., Duley L., Henderson-Smart D. et al. Antiplatelet agents for prevention of preeclampsia: meta-analysis of individual patient data. Lancet. 2007; 369: 1791-8][Dekker G. A., Sibai B. M. Low - dose aspirin in the prevention of preeclampsia and fetal growth retardation. Am. J. Obstet. Gynecol. 1993; 168: 214-7][Duley L., Henderson-Smart D., Knight M., King J. F. Antiplatelet agents for preventing preeclampsia and its complications. Cochrane Database Syst. Rev. 2004: CD 004659][Lockwood C. J., Krikun G., Rahman M. et al. The role of decidualization in regulating endometrial hemostasis during menstrual cycle, gestation and in pathological states. Semin. Thromb. Hemost. 2007; 33: 111-7][Patrono C. Aspirin as an antiplatelet drug. N. Eng. J. Med.1994; 330: 1287-94][Schiff E., Barkai G., Ben-Baruch G., Mashiach S. Low - dose aspirin does not influence the clinical course of women with mild pregnancy induced hypertension. Obstet. Gynecol.1990; 76: 742-4]