Journal of obstetrics and women's diseasesJournal of obstetrics and women's diseases1684-04611683-9366Eco-Vector125210.17816/JOWD64352-57Research ArticleAnti-D-immunoprophylaxisPavlovaNataliya Grigor’yevnaProfessor, the principal of laboratory of physiology and a pathophysiology of a fetus with unit of ultrasonic diagnosticsngp05@yandex.ruD. O. Ott Research Institute of Obstetrics and Gynecology, RAMS15062015643525715062015Copyright © 2015, Pavlova N.G.2015The working out and introducing of anti-D-immunoprofylaxis program in the time of pregnancy in foreign countries and Russia are discussed, effectiveness of its long-term using on the base of the federal programs in developed European countries and America is analyzed; necessity and economic advisability of its introducing on the base of the federal and municipal programs in Russia from the evidence-based medicine point of view are considered, indications and arguable points of the program are discussed.Rh-isoimmunization during pregnancyanti-D-immunoprophylaxis, hemolytic disease of the fetusRh-изоиммунизация при беременностианти-D-иммунопрофилактикагемолитическая болезнь плода[Васильева З. Ф. Антиген-несовместимая беременность и методы защиты плода и новорожденного при иммунологическом конфликте. Автореф. дис… д-ра мед. наук. Л.; 1972.][Bowman J. M. Тhе prevention of Rh immunisation. Transfusion Medicine Reviews. 1988; 2: 129-50.][Bowman J. M., Pollock J. M. Transplacental fetal hemorrhage after amniocentesis. Obstet.Gynec.1985; 66: 749-54.][Chrown B. Anemia from bleeding of the fetus into the mother`s circulation. Lancet. 1954; 1: 1213-5.][Duguid J. K. M., Bromilow I. M. Laboratory measurement of fetomaternal haemorrhage and its clinical relevance. Transfusion Medicine Reviews. 1999; 13: 43-8.][Everett C. Incidence and outcome of bleeding before the 20th week of pregnancy: prospective study of general practice. Br. Med. J. 1997; 315: 32-4.][Finn R., Clarke C. A., Donohue W. T. A. et al. Experimental studies on the preventation of Rh haemolytic disease. Br. Med. J. 1961; 1: 1486-90.][Gunson H. H. Neonatal anemia due to fetal hemorrhage into the maternal circulation. Pediatrics. 1957; 20: 3-6.][McMaster Conference. Conference on prevention of Rh immunization. Von Sanguinis. 1979; 36: 56-64.][Mollison P. L., Engelfriet C. P., Contreras M. Blood Transfusion in Clinical Medicine, 10th edition. Oxford: Blackwell Scientific Publications, 1997, Chapter 12.][Rodeck C. H., Sheldrake A., Beatie B., Whittle M. J. Maternal serum alphafetoprotein after placental damage in chorionic villus sampling. Lancet. 1993; 341: 500.][Stott L. M., Наll А. М., Wilson D. W. L. et al. Helper Т-сеll epitopes on the RhD protein - towards а peptide vaccine for prevention of Rh disease. Transfusion Medicine. 1999; 9 (suppl 1): 54.][Torrence G. W., Zipursky A. Cost-effectiveness of antepartum prevention of Rh immunization. Clinical Perinatology. 1984; 11: 267-81.][Woodrow J. C., Clarke C. A., Donohue W. T. A. et al. Prevention of Rh-haemolytic desease: a third report. Br.Med. J. 1965; 1: 279-83.][World Health Organization. Prevention of Rh-sensitization. Technical Report Series. 1971; 468p.]