Journal of obstetrics and women's diseasesJournal of obstetrics and women's diseases1684-04611683-9366Eco-Vector8869110.17816/JOWD88691Research ArticleOn the model of hormonal carcinogenesis on the example of uterine leiomyoma: problems and prospectsVikhlyaevaE. M.info@eco-vector.comScientific Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences3001200150113171811202118112021Copyright © 2021, Eсо-Vector2021<p>The main principles of progesterone hypothesis and the role of auto- and paracrine factors in uterine leiomyoma pathobiology are considered in the article. The necessity of early therapeutic intervention since humor detection is maintained with the aim of reproductive health recovery. The basic features of strategy in case of uterine leiomyoma are defined: measures due to be undertaken since humor detection, determination of limits and possibilities of adjuvant medicamental treatment and optimal time for surgery, conducting patients in peri- and postmenopause and evaluation of oncological risk.</p>hormonal carcinogenrestoration of a woman's reproductive healthгормональный канцерогенвосстановление репродуктивного здоровья женщины