Journal of obstetrics and women's diseasesJournal of obstetrics and women's diseases1684-04611683-9366Eco-Vector8896410.17816/JOWD88964Research ArticleProliferative activity of the epithelium in squamous epithelial lesions of the cervixManukhinI. B.info@eco-vector.comMinkinaG. .N.info@eco-vector.comMoscow State University of Medicine and Dentistry3001200150134362411202124112021Copyright © 2021, Eсо-Vector2021<p>As a criterion for precancerous changes in the stratified squamous epithelium of the cervix, its proliferative activity, studied using monoclonal antibodies PC-10 to the antigen of proliferating cell nuclei (PCNA), is considered. The results of the studies showed that patients with a low degree of squamous intraepithelial lesion are characterized by weak proliferative activity, and for patients with a high degree of lesion it is moderate and pronounced. An increase in proliferative activity is a prognostic factor that determines long-term persistence and the likely progression of the lesion.</p>proliferative activity of the epitheliummonoclonal antibodies PC-10пролиферативная активность эпителиямоноклональные антитела PC-10