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Catastrophic Antiphospholipid Syndrome in Obstetric Practice

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1. Title Title of document Catastrophic Antiphospholipid Syndrome in Obstetric Practice
2. Creator Author's name, affiliation, country Alexander D Makatsariya; First Moscow State Medical University
2. Creator Author's name, affiliation, country Viktoriya O Bitsadze; I. M. Sechenov First Moscow State Medical University
2. Creator Author's name, affiliation, country Dzhamilya Kh Khizroeva; I. M. Sechenov First Moscow State Medical University
3. Subject Discipline(s)
3. Subject Keyword(s) pregnancy; pregnancy complications; thrombsis
4. Description Abstract Catastrophic antiphospholipid syndrome (CAPS) is an uncommon, often fatal, form of the antiphospholipid syndrome that results in a widespread coagulopathy and affects predominantly small vessels supplying organs with the development of multiorgan failure against a background of high level of antiphospholipid antibodies. Thrombotic microvasculopathy is the basis of multiorgan failure and clinically manifests with CNS disturbances, adrenal failure, and the development of acute respiratory distress syndrome. CAPS is a life-threatening condition and requires urgent measures. Optimal treatment for CAPS is not developed yet. CAPS present a multidisciplinary problem. Authors demonstrate 17 cases of CAPS in patients which were managed from 2001 to 2012 years. Molecular mechanisms of pathogenesis and different obstetric and non-obstetric manifestations of CAPS are discussed in the article. There is the description of first case of management of pregnancy and labor of patient with CAPS in her history. The methods of CAPS prevention are described
5. Publisher Organizing agency, location Eco-Vector
6. Contributor Sponsor(s)
7. Date (DD-MM-YYYY) 15.06.2012
8. Type Status & genre Peer-reviewed Article
8. Type Type Research Article
9. Format File format
10. Identifier Uniform Resource Identifier https://journals.eco-vector.com/jowd/article/view/1281
10. Identifier Digital Object Identifier (DOI) 10.17816/JOWD6137-21
10. Identifier Digital Object Identifier (DOI) (PDF (Rus)) 10.17816/JOWD1281-901
11. Source Title; vol., no. (year) Journal of obstetrics and women's diseases; Vol 61, No 3 (2012)
12. Language English=en ru
13. Relation Supp. Files
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
15. Rights Copyright and permissions Copyright (c) 2012 Makatsariya A.D., Bitsadze V.O., Khizroeva D.K.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.