Clinical and epidemiological characteristic of chronic brucellosis

Cover Page

Abstract


Aim. To study clinical epidemiological and laboratory features of chronic brucellosis in the Republic of Tatarstan in ten-year aspect.

Methods. 59 patients infected with various forms of brucellosis in 2007-2017 were examined. Clinical laboratory and instrumental diagnosis of brucellosis was confirmed by the immunoassay (EIA) with determination of IgM and IgG antibodies, passive hemagglutination test with a brucellar diagnosticum, Coombs test, Wright and Hedelson agglutination test.

Results. Clinically 91 % of patients had asthenic-vegetative syndrome, 55 % - mild intoxication symptoms, 89 % - articular syndrome, 49 % - fibrositis. EIA revealed in 91 % of patients IgG (38 %) and IgM (53 %) antibodies to causative agents of brucellosis, 25 % of patients had positive Wright agglutination test, and 30 % - positive Hedelson agglutination test. In 9 % of cases the diagnosis was confirmed by Coombs test and in 26 % by passive hemagglutination test with brucellar diagnosticum. The retrospective analysis with clinical cases of patients with chronic brucellosis indicates introduced cases in 19 % (from the republics of Central Asia and Transcaucasia), local cases in 81 % (from the Republic of Tatarstan), their occupational character (57 %), the mixed (contact and alimentary) route of infection (21 %), and 64 % with clinically primary involvement of the musculoskeletal system and peripheral nervous system, i.e. prevalence of the mixed form of chronic brucellosis.

Conclusion. Chronic brucellosis in the Republic of Tatarstan is characterized by high risk of introduced cases, occupational history, prevalence of the mixed route of infection in females and working-age patients; with the features of systemic disease involving the musculoskeletal and peripheral nervous system against the background of mild syndrome of intoxication and moderate asthenic-vegetative syndrome. Divergence of the results of serological diagnostics requires careful studying of duration of infection, features of the immune response in each case on follow-up.


V Kh Fazylov

Kazan State Medical University

Author for correspondence.
Email: fairuza1@yandex.ru
Kazan, Russia

F S Gilmullina

Kazan State Medical University

Email: fairuza1@yandex.ru
Kazan, Russia

Z L Khamidullina

Republican Clinical Hospital of Infectious Diseases n.a. prof. A.F. Agafonov

Email: fairuza1@yandex.ru
Kazan, Russia

G V Galina

Kazan State Medical University

Email: fairuza1@yandex.ru
Kazan, Russia

  • Orakbay L.Zh., Cherepanova L.Yu., Denisova T.G. Modern aspects of epidemic brucellosis. Sovremennye problemy nauki i obrazovaniya. 2015; 6. https://science-education.ru/ru/article/view?id=22737. (In Russ.)
  • Infektsionnye bolezni: natsionalʹnoe rukovodstvo. (Infectious diseases: national guide.) Ed. by N.D. Yushchuk, Yu.V. Vengerova. 2nd ed. Moscow: GEOTAR-Media, 2018. 1104 p. (In Russ.)
  • Profilaktika brutselleza: Sanitarno-ehpidemiologicheskie pravila — SP 3.1.7.2613-10. (Prevention of brucellosis: samitary epidemiological rules - SP 3.1.7.2613-10.) Moscow: Federalʹnyy Tsentr gigieny i ehpidemiologii Rospotrebnadzora. 2010; 27 p.
  • (In Russ.)
  • Profilaktika i laboratornaya diagnostika brutselleza lyudey: Metodicheskie ukazaniya MU 3.1.7.1189- 03. (Prevention and laboratory diagnosis of human brucellosis: methodological guidelines.) Moscow: Federalʹnyy tsentr gossanehpidnadzora Minzdrava Rossii. 2003; 58 p. (In Russ.)
  • Metodicheskie ukazaniya (MUK 4.2.3010-12) «Poryadok organizatsii i provedeniya laboratornoy diagnostiki brutselleza dlya laboratoriy territorialʹnogo, regionalʹnogo i federalʹnogo urovney». (Practical policies (MUK 4.2.3010-12) «The order of organization and perfoming of laboratory diagnosis of brucellosis for territorial, regional and federal laboratories».) Moscow: Federalʹnyy Tsentr gigieny i ehpidemiologii Rospotrebnadzora. 2013; 67 p. (In Russ.)
  • Fazylov V.Kh., Gilmullina F.S., Zagidullina A.I., Khamidullina Z.L. Diagnosis and treatment of chronic brucellosis in actual practice. Prakticheskaya meditsina. 2014; (7): 72–75. (In Russ.)
  • Safonov A.D. Pnevskiy Yu.A., Nurpeysova A.Kh. Brucellosis — acute zoonotic infection on the territory of the Omsk region. Ehpidemio­logiya i infektsionnye bolezni. 2017; 22 (3): 134–138. (In Russ.)
  • Ereniev S.I., Demchenko V.G., Plotnikova O.V., Safonov A.D., Rudakov N.V., Gordienko L.I., Ponomareva O.G., Tarkhov A.E. ­Sanitarno-gigienicheskie i kliniko-immunologicheskie aspekty professionalʹnogo brutselleza v sovremennykh usloviyakh. (Sanitary hygenic and clinical immunological aspects of occupational brucellosis in modern conditions.) Ed. by V.G. Demchenko, A.D. Safonov, N.V. Rudakov, S.I. Ereniev. Saint Petersburg: Tessa, 2014; 220 p. (In Russ.)
  • Sannikova I.V., Makhinya O.V., Maleev V.V., et al. Brucellosis in the Stavropol Kray: the results of 15-year follow-up of epidemiological and clinical features. Terapevticheskiy arkhiv. 2015; (11): 11–17. (In Russ.)
  • Sergeeva I.V. Mistakes in chronic brucellosis diagnosis. Sovremennye problemy nauki i obrazovaniya. 2013; 4. http://science-education.ru/ru/article/view?id=9838. (In Russ.)

Views

Abstract - 25

PDF (Russian) - 29

PlumX


© 2018 Fazylov V.K., Gilmullina F.S., Khamidullina Z.L., Galina G.V.

Creative Commons License

This work is licensed
under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.


Свидетельство о регистрации СМИ ЭЛ № ФС 77-70434 от 20 июля 2017 года выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор)