Health features of newborns depending on vitamin D level of their mothers during pregnancy

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Aim. Evaluation of health state in newborns whose mothers were at risk of pre-eclampsia, depending on vitamin D level.

Methods. Study materials included peripheral blood from pregnant women and umbilical cord blood of newborns. Vitamin D level was measured by enzyme-linked immunoassay kits of BIOMEDICAGRUPPE company (Germany). Intrauterine fetal state was studied with the use of ultrasonography.

Results. Analysis of the study proved that vitamin D level in the umbilical cord blood correlates with its concentration in the mother’s blood. In women at pre-eclampsia risk decreased calcium level and vitamin D deficiency in the blood were detected. Administration of 2,000 IU of vitamin D and 1.5 g of calcium from the beginning of 2nd trimester of pregnancy resulted in reduction of frequency and severity of pre-eclampsia and its complications, including intrauterine growth retardation. Use of vitamin D in combination with calcium supplementation was shown to significantly improve unfavorable perinatal outcomes in women at high risk of pre-eclampsia, reducing by 3 times hypoxia and cerebral fetal lesions frequency that proves the vitamin D importance for functioning of mother-placenta-fetus system.

Conclusion. Children of patients at risk of pre-eclampsia not taking vitamin D and calcium supplementation have lower birth weight and Apgar score, they have more frequent perinatal complications.

E N Vasil’eva

Author for correspondence.
Chuvash State University named after I.N. Ulyanov Cheboksary, Russia

L I Mal’tseva
Kazan State Medical Academy Kazan, Russia

T G Denisova
Chuvash State University named after I.N. Ulyanov; Postgraduate Doctors’ Training Institute Cheboksary, Russia; Cheboksary, Russia

L I Gerasimova
Postgraduate Doctors’ Training Institute Cheboksary, Russia

  • Акушерство. Учебник. Под ред. В.Е. Радзинского, А.М. Фукса. М.: ГЭОТАР-Медиа. 2016; 1040 с.
  • Alpert P.T., Shaikh U. The effects of vitamin D deficiency and insufficiency on the endocrine and paracrine systems. Biol. Res. Nurs. 2007; 9 (2): 117-129. doi: 10.1177/1099800407308057.
  • Heaney R.P. Vitamin D in health and disease. Clin. J. Am. Soc. Nephrol. 2008; 3 (5): 1535-1541. doi: 10.2215/CJN.01160308.
  • Holick M.F. Medical progress: vitamin D deficiency. N. Engl. J. Med. 2007; 357 (3) 266-281. doi: 10.1056/NEJMra070553.
  • Holmes V.A., Barnes M.S., Alexander H.D. et al. Vitamin D deficiency and insufficiency in pregnant women: A longitudinal study. Br. J. Nutr. 2009; 102 (6): 876-881. doi: 10.1017/S0007114509297236.
  • Денисова Т.Г., Васильева Э.Н., Шамитова Е.Н., Ассанский В.Г. Обеспеченность витамином D пациенток с преэклампсией. Соврем. пробл. науки и образования. 2015 (3). (дата обращения: 09.01.2017).
  • Bodnar L.M., Catov J.M., Simhan H.N. Maternal vitamin D deficiency increases the risk of preeclampsia. J. Clin. Endocrinol. Metab. 2007; 92 (9): 3517-3522. doi: 10.1210/jc.2007-0718.
  • Мальцева Л.И., Васильева Э.Н., Денисова Т.Г. Витамин D и преэклампсия. Рос. вестн. акушера-гинеколога. 2016; 16 (1): 79-83. doi: 10.17116/rosakush201616179-83.
  • Lapillonne A. Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes. Med. Hypotheses. 2010; 74 (1): 71-75. doi: 10.1016/j.mehy.2009.07.054.
  • Lewis S., Lucas R.M., Halliday J., Ponsonby A.-L. Vitamin D deficiency and pregnancy: From preconception to birth. Mol. Nutr. Food. Res. 2010; 54 (8): 1092-1102. doi: 10.1002/mnfr.201000044.
  • Liu N.Q., Kaplan A.T., Lagishetty V. et al. Vitamin D and the regulation of placental inflammation. J. Immunol. 2011; 186 (10): 5968-5974. doi: 10.4049/jimmunol.1003332.
  • Lanham-New S.A., Buttriss J.L., Miles L.M. et al. Proceedings of the rank forum on vitamin D. Br. J. Nutr. 2011; 105 (1): 144-156. doi: 10.1017/S0007114510002576.
  • Lucas R.M., Ponsonby A.-L., Pasco J.A., Morley R. Future health implications of prenatal and early-life vitamin D status. Nutrition Rev. 2008; 66 (12): 710-720. doi: 10.1111/j.1753-4887.2008.00126.x.
  • Mirzakhani H., Litonjua A.A., McElrath T.F. et al. Early pregnancy vitamin D status and risk of preeclampsia. J. Clin. Invest. 2016; 126 (12): 4702-4715. doi: 10.1172/JCI89031.
  • Marwaha R.K., Tandon N., Reddy D.R. et al. Vitamin D and bone mineral density status of healthy schoolchildren in northern India. Am. J. Clin. Nutr. 2005; 82 (2): 477-482. PMID: 16087996.


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© 2017 Vasil’eva E.N., Mal’tseva L.I., Denisova T.G., Gerasimova L.I.

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