Morphological features of the corneal endothelium in patients with pseudoexfoliative glaucoma



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Abstract

Abstract

Purpose. To study the main morphological features of the corneal endothelium in patients with pseudoexfoliative glaucoma (PEG).

Methods:

We included 193 subjects aged from 55 to 75 years. The main study group (PEG)  included 96 patients (192 eyes), the POAG group included 36 patients (72 eyes) with primary open angle glaucoma (POAG), the PEX group included 31 patients (62 eyes) with pseudoexfoliation syndrome without glaucoma. The control group (CG) comprised of 30 healthy subjects (60 eyes). The main corneal endothelium parameters were evaluated using a non-contact endothelial microscope EM-935 (Haag Streit, Switzerland). The data were analyzed by STATISTICA 9 software for Windows.

Results:

The patients with PEG had lower endothelial cell density (ECD) compared to the control group (CG) (p<0.01), and PEX group (p<0.05).

The polymegatism level in patients with PEG and POAG was higher than in the control group (p<0.001, and p<0.01, correspondingly). In patients with moderate and advanced PEG, the ECD was significantly lower (p<0.01), and the polymegatism level was significantly higher (p<0.01) than those in patients with early PEG. The lowest ECD and the highest polymegatism percentage were observed in PEG patients with more pronounced PEX manifestations, p<0.05. No effect of IOP-lowering eye drops on the corneal endothelium parameters was revealed, p>0.05.

Conclusions: Significant morphological changes of corneal endothelium (decreased endothelial cell density, increased polymegatism percentage) were revealed in patients with PEG. It was established that the severity of these changes is associated with the PEG and PEX severity. No effect of IOP-lowering eye drops on the corneal endothelium parameters was detected.

 

About the authors

Inessa Stanislavovna Beletskaya

FSBEI HE “Academician I.P. Pavlov First St Petersburg State Medical University” of the Ministry of Healthcare of Russia, Saint Petersburg, Russia

Author for correspondence.
Email: glaziki@list.ru
ORCID iD: 0000-0003-4827-0248

Ophthalmologist. Ophthalmology Department.

Russian Federation,  197022, Russia, Saint Petersburg, L’va Tolstogo street, 6-8

Sergey Yurievich Astakhov

FSBEI HE “Academician I.P. Pavlov First St Petersburg State Medical University” of the Ministry of Healthcare of Russia, Saint Petersburg, Russia

Email: astakhov73@mail.ru

MD, PhD, DMedSc  professor, head of the department. Ophthalmology Department.

Russian Federation, 197022, Russia, Saint Petersburg, L’va Tolstogo street, 6-8

Natatlya Viktorovna Tkachenko

FSBEI HE “Academician I.P. Pavlov First St Petersburg State Medical University” of the Ministry of Healthcare of Russia, Saint Petersburg, Russia

Email: natalyatkachenko@yandex.ru

MD, PhD, assistant. Ophthalmology Department

Russian Federation, 197022, Russia, Saint Petersburg, L’va Tolstogo street, 6-8

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