Ophthalmology ReportsOphthalmology Reports1998-71022412-5423Eco-Vector10931210.17816/OV109312Research ArticleEvaluation of incidence of the adult-onset vitelliform macular dystrophy among patients in Far Eastern Federal District of RussiaDanilovOleg V.<p>Ophthalmologist</p>dvk@khvmntk.ruhttps://orcid.org/0000-0002-6610-2419KolenkoOleg V.<p>Dr. Sci. (Med.), Director of the Khabarovsk Branch</p>naukakhvmntk@mail.ruhttps://orcid.org/0000-0001-7501-5571SorokinEvgenii L.<p>Dr. Sci. (Med.), Professor</p>naukakhvmntk@mail.ruhttps://orcid.org/0000-0002-2028-1140ZhirovArkadiy L.<p>Head of the Diagnostic Department, Ophthalmologist</p>naukakhvmntk@mail.ruhttps://orcid.org/0000-0003-0226-9014ZhazybaevRuslan S.<p>Ophthalmologist</p>naukakhvmntk@mail.ruhttps://orcid.org/0000-0002-6201-5051S.N. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk BranchPostgraduate Institute for Public Health WorkersFar-Eastern State Medical University211220221531011081307202202092022Copyright © 2022, ECO-vector LLC2022<p><strong><em>BACKGROUND</em></strong><em>:</em> Adult-onset vitelliform macular dystrophy is one of the pathologic conditions , which successfully masks as age-related macular degeneration.</p>
<p><strong><em>AIM</em></strong><em>: </em>To assess the incidence of the adult-onset vitelliform macular dystrophy among patients of a major ophthalmological clinic in the Far Eastern Federal District of Russia.</p>
<p><strong><em>MATERIALS AND METHODS</em></strong><em>: </em>We revealed the cases of adult-onset vitelliform macular dystrophy among 1000 patients aged 40 years and older who addressed for various ocular complaints.</p>
<p><strong><em>RESULTS</em></strong><em>: </em>Adult-onset vitelliform macular dystrophy was found in 2 male patients aged 43 and 66 years. In the macular area of both eyes of the 1<sup>st</sup> patient, round yellow lesions in the foveola, local detachment of neuroepithelium, optically dense material deposits on the outer photoreceptor segments were detected (vitelliruptive stage of adult-onset vitelliform macular dystrophy). In the left eye of the 2<sup>nd</sup> patient, in the foveola, a single round yellow focus of 200 m was found, optically dense vitelliform material was detected between the pigment epithelium and neuroepithelium layers without any signs of choroidal neovascularization (vitelliform stage of adult-onset vitelliform macular dystrophy).</p>
<p><strong><em>CONCLUSIONS</em></strong><em>: </em>The incidence of adult-onset vitelliform macular dystrophy among patients with various ocular conditions was 0.2%. Morphological changes in the macula consist in presence of deposits of vitelliform material, localized between the neuroepithelium and retinal pigment epithelium layers.</p>adult-onset vitelliform macular dystrophyage-related macular degenerationoptically dense vitelliform materialвителлиформная макулярная дистрофия взрослыхвозрастная макулярная дегенерацияоптически плотный вителлиформный материал[Gass JD. A clinicopathologic study of a peculiar foveomacular dystrophy. Trans Am Ophthalmol Soc. 1974;72:139–156.][Boriskina LN, Guro MYu, Potapova VN. Primenenie sovremennykh metodov vizualizatsii v diagnostike bolezni Besta i vitelliformnoi makulyarnoi distrofii vzroslykh. Journal of Volgograd State Medical University. 2013;(S):50–52. (In Russ.)][Matcko NV, Gatsu MV, Grigoryeva NN. Vitelliform changes in the central retina occurring in adults. Ophthalmology Journal. 2019;12(4):73–86. (In Russ.) DOI: 10.17816/OV18513][Glacet-Bernard A, Soubrane G, Coscas G. Macular vitelliform degeneration in adults. Retrospective study of a series of 85 patients. J Fr Ophtalmol. 1990;13(8–9):407–420.][Puche N, Querques G, Benhamou N, et al. High-resolution spectral domain optical coherence tomography features in adult onset foveomacular vitelliform dystrophy. Br J Ophthalmol. 2010;94(9): 1190–1196. DOI: 10.1136/bjo.2009.175075][Chowers I, Tiosano L, Audo I, et al. Adult-onset foveomacular vitelliform dystrophy: A fresh perspective. Prog Retin Eye Res. 2015;47:64–85. DOI: 10.1016/j.preteyeres.2015.02.001][Deak GG, Schmidt WM, Bittner RE, et al. Imaging of vitelliform macular lesions using polarization-sensitive optical coherence tomography. Retina. 2019;39(3):558–569. DOI: 10.1097/IAE.0000000000001987][Nordstrom S. Hereditary macular degeneration — a population survey in the county of Vasterbotten, Sweden. Hereditas. 1974;38(1): 41–62. DOI: 10.1111/j.1601-5223.1974.tb01427.x][Dalvin LA, Pulido JS, Marmorstein AD. Vitelliform dystrofies: Prevalence in Olmsted County, Minnesota, United States. Ophthalmic Genet. 2016;38(2):143–147. DOI: 10.1080/13816810.2016.1175645][Bitner H, Shatz P, Mizrahy-Meissonnier L, et al. Frequency, genotype, and clinical spectrum of best vitelliform macular dystrophy: data from a national center in Denmark. Am J Optthalmol. 2012;154(2):403–412. DOI: 10.1016/j.ajo.2012.02.036][Benhamou N, Souied E, Zolf R, et al. Adult-onset foveomacular vitelliform dystrophy: a study by optical coherence tomography. Am J Ophthalmol. 2003;135(3):362–367. DOI: 10.1016/s0002-9394(02)01946-3][Gass JD. Stereoscopic atlas of macular diseases: diagnosis and treatment. 4th ed. St Louis: Mosby-Year Book Inc., 1997. 1061 p.][Arnold J, Sarks J, Killingsworth M, et al. Adult vitelliform macular degeneration: a clinicopathological study. Eye. 2003;17(6): 717–726. DOI: 10.1038/sj.eye.6700460][Querques G, Bux A, Prato R, et al. Correlation of visual function impairment and optical coherence tomography findings in patients with adult-onset foveomacular vitelliform macular dystrophy. Am J Ophthalmol. 2008;146(1):135–142. DOI: 10.1016/j.ajo.2008.02.017]