Ophthalmology ReportsOphthalmology Reports1998-71022412-5423Eco-Vector11095710.17816/OV110957Research ArticleVisual functions in patients with cytomegalovirus uveitis and HIV infectionSizovaTatiana D.<p>Ophthalmologist, PhD Student</p>tanja_sizova@list.ruhttps://orcid.org/0000-0003-4089-1242KhokkanenValentina M.<p>Dr. Sci. (Med.), Professor, Professor of the Ophthalmology Department</p>valentina.khokkanen@szgmu.ruhttps://orcid.org/0000-0001-8096-5088ZumbulidzeNatalia G.<p>Cand. Sci. (Med.), Associate Professor of Ophthalmology Department</p>guramovna@gmail.comhttps://orcid.org/0000-0002-7729-097XBoikoErnest V.<p>Dr. Sci. (Med.), Professor, Head of the Ophthalmology Department; Corresponding member of the Military Medical Academy; Director</p>boiko111@list.ruhttps://orcid.org/0000-0002-7413-7478Saint Petersburg Center for Control of AIDS and Infectious DiseasesNorth-Western State Medical University named after I.I. MechnikovKirov Military Medical AcademyS.N. Fyodorov Eye Microsurgery Federal State Institution, the Saint Petersburg Branch2112202215347551709202228112022Copyright © 2022, Sizova T.D., Khokkanen V.M., Zumbulidze N.G., Boiko E.V.2022<p><strong><em>BACKGROUND</em></strong><em>: </em>Cytomegalovirus damage to the eye is the leading cause of loss of visual functions associated with HIV. Effective treatment of HIV-infected patients has changed the understanding of the clinical picture of cytomegalovirus uveitis (CMV-uveitis).</p>
<p><strong><em>AIM</em></strong><em>: </em>The aim of the work is to determine the prevalence, the structure of clinical forms and to evaluate visual functions in HIV-infected patients with CMV-uveitis.</p>
<p><strong><em>MATERIALS AND METHODS</em></strong><em>: </em>The study group consisted of 66 HIV-infected patients with CMV-uveitis (97 eyes), of which there were 27 men (40.9%), 39 women (59.1%). The average age was 39.6 3.91 years. All patients had stage 4B of HIV infection according to V.V. Pokrovskys classification (2006). During the work, visometry, perimetry, biomicroscopy, ophthalmoscopy were used.</p>
<p><strong><em>RESULTS</em></strong><em>: </em>The main form of the disease is chorioretinitis, diffuse and generalized forms of the disease are diagnosed in 68.0% of cases. In predicting visual acuity, the leading regression criterion was the clinical form of the disease.</p>
<p><strong><em>CONCLUSIONS</em></strong><em>: </em>Diffuse and generalized forms of the disease prevailed in clinical practice. Localization of the chorioretinal process of a predominantly diffuse nature predetermined visual acuity, which in more than a third of cases met the criteria for blindness according to the WHO classification (1977).</p>cytomegalovirus uveitishuman immunodeficiency virus (HIV)HIV-infectionopportunistic diseaseцитомегаловирусный увеитвирус иммунодефицита человекаВИЧВИЧ-инфекцияоппортунистические заболевания[Kestelyn PG, Cunningham ET. HIV/AIDS and blindness. Bulletin of the World Health Organisation. 2001;79(3):208–213.][Holbrook JT, Jabs DA, Weinberg DV, et al. Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy. Arch Ophthalmol. 2003;121:99–107. DOI: 10.1001/archopht.121.1.99][Onishchenho AL, Kolbasko AV, Tatarnikova GN, Chernysheva AD. 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