Ophthalmology ReportsOphthalmology Reports1998-71022412-5423Eco-Vector32110.17816/OV2015122-27The level of local cytokine production at different times after experimental ciliary body cryodestructionSteblyukAleksey Nikolaevichcandidate of medical science, ophthalmologist-KolesnikovaNatal'ya Vladislavovnadoctor of biological science, professor. Immunology, Allergology and Laboratory Testing departmenttroickaya@rambler.ruGyunterViktor Eduardovichdoctor of technical science, professor-BodnyaVadim Nikolaevichdoctor of medical science, assistant professor. Oncology and Thoracic Surgery departmentvadimbodnya@rambler.ruTserkovnayaAnna Alekseevnaoncologist, aspirant5247024@gmail.comS. N. Fyodorov Eye Microsurgery Complex, Krasnodar BranchKuban State Medical UniversityResearch Institute of Shape Memory Material under Siberian Physico-technical InstituteClinical oncology hospital N 11503201581222724062015Copyright © 2015, Steblyuk A.N., Kolesnikova N.V., Gyunter V.E., Bodnya V.N., Tserkovnaya A.A.2015We assessed the level of pro- (IL1β, FNOα, IL2) and anti-inflammatory (IL10) cytokines in the anterior chamber fluid of experimental animals on the 3rd, 7th and 30th day, after an experimental ciliary body destruсtion with porous titanium nickelid cryoapplicator. Consistent changes of the cytokine content at the local level are reflecting the reactivity of the experimental animals as an answer both to surgery in ciliary body area, and to its experimental cyclodestruction using the cryoapplicator from titanium nickelid. The predominance of pro-inflammatory cytokines’ potential was found during the early period (3-7 day), and the balance normalization of pro- and anti-inflammatory cytokines was found at late observation period (30 days) due to the increase of the anti-inflammatory IL-10 production; this effect was maintained at the end of the long-term study period (1.5 years).ciliary bodycryosurgerytitanium nickelidexperimental animalsцилиарное телокриохирургияникелид титаналабораторные животные[Астахов С. Ю., Астахов Ю. С. Современные тенденции в хирургическом лечении глауком. Глаукома: проблемы и решения. Всероссийская научно-практическая конференция. Москва. 2004; 257-61.][Керимов К. Т., Джафаров А. И., Гахраманов Ф. С. Ожоги глаз: патогенез и лечение, М.: РАМН. 2005; 462.][Мельник Д. Д., Гюнтер В. Э., Дамбаев Г. Ц. и соавт. Медицинские материалы и имплантаты с памятью формы. Пористо-проницаемые криоаппликаторы из никелида титана в медицине. Томск: Изд-во «НПП МИЦ». 2010; 9: 304.][Шилов Ю. И., Гаврилова Т. В., Черешнева М. В., Шилов С. Ю., Усова В. В., Медведева С. Ю., Блинкова Н. Б. Механизмы изменений функций иммунной системы и иммунокорригирующего действия миелопида и полиоксидония при проникающем ранении глаза. Росс. иммунол. журнал. 2013; 7 (16), 2-3; 211.][Hoang-Xuan T., Baudouin C., Creuzot-Garcher C. Inflammatory Deseases of the Conjunctiva. New York: Thime. 2001; 172.][Mondal S. K. Mucosa-associated lymphoid tissue lymphoma in conjunctiva. Indian J. Pathol.Microbiol. 2008; 51 (3): 407-8.]