Ophthalmology ReportsOphthalmology Reports1998-71022412-5423Eco-Vector43610.17816/OV2013122-25Immunomorphological features of “classic” and “occult” choroidal neovascular membranes in age-related macular degenerationAltynbayevUral RifovichPhD in medicineuralaltynbaev@rambler.ruSerezhinIgor NikolayevichMDserejine@mail.ruAltynbayevaLiana RimovnaPhD in medicineuralaltynbaev@rambler.ruTatneft1503201361222524062015Copyright © 2013, Altynbayev U.R., Serezhin I.N., Altynbayeva L.R.2013A comparative evaluation of morphological features and proliferative activity of “classic” and “occult” choroidal neovascular membranes (CNM) in patients with the wet form of age-related macular degeneration was carried out. It was found that the CNM proliferative activity depends on the membrane type. The presence of a high pigment epithelium detachment in patients with “occult” CNM may be due to the presence of a solid avascular scar in the subretinal space.transforming growth factor-b1proliferating cell nuclear antigenchoroidal neovascular membraneage-related macular degenerationтрансформирующий фактор роста-b1ядерный антиген пролиферирующих клетокхориоидальная неоваскулярная мембранавозрастная макулярная дегенерация[Будзинская М. В., Гурова И. В. Субретинальная неоваскулярная мембрана при возрастной макулярной дегенерации // Вестн. офтальмол. — 2006. — № 4. — С. 49–54.][Пальцев, М. А., Иванов А. А. Межклеточные взаимодействия // М.: Медицина. — 1995. — 224 с.][Туманова, А. Л., Еременко А. И. Микроэлементозы и их влияние на возникновение и клинику диабетических, атеросклеротических и сосудистых нейроретинопатий — Краснодар, 2002. — 228 с.][Bravo R., MacDonald-Bravo H. Changes in the nuclear distribution of cyclin (PCNA) but not its synthesis depend on DNA replication. //EMBO J. — 1985. — Mar, 4(3). — P. 655–661.][Celis J. E., Madsen P. Increased nuclear cyclin/PCNA antigen staining of non S-phase transformed human amnion cells engaged in nucleotide excision DNA repair // FEBS Lett. — 1986. — Dec. 15, 209(2). — P. 277–283.][Celis J. E., Madsen P., Nielsen S., Celis A. Nuclear patterns of cyclin (PCNA) antigen distribution subdivide S-phase in cultured cells — some applications of PCNA antibodies // Leuk. Res. 1986. — 10(3). — P 237–249.][Klein R. Prevalence of age-related maculopathy // The Beaver Dam Eye Study. Ophthalmology. — 1992. — Vol. 99. — P. 933–942.][Liebowitz H. M., Krueger D. E., Maunder L. R., Milton R. C. The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration and visual acuity in a general population of 2631 adults, 1973–1975. // Surv. Ophthalmol. — 1980. — Vol. 24. — P. 335–610.][Rodemann, H. P. The underlying cellular mechanism of fibrosis //Kidney Int Suppl. — 1996. — Vol. 54. — P.32–36.]