Ophthalmology ReportsOphthalmology ReportsОфтальмологические ведомости1998-71022412-5423Eco-Vector6411610.17816/OV64116Original study articlesОригинальные исследованияResearch ArticleEvaluation of retinal thickness and of pseudophakic cystoid macular edema incidence in patients with primary open-angle glaucoma treated with prostaglandin analoguesОценка толщины сетчатки и частоты развития псевдофакичного кистозного макулярного отека у больных ПОУГ, получающих аналоги простагландинов评估应用前列腺素类似物的原发性开角型青光眼患者的视网膜厚度和白内障术后囊性黄斑水肿发生率https://orcid.org/0000-0002-1135-6796WangXiaoyuanВанСяоюаньWangXiaoyuan
Russian Federation

PhD student

аспирант

PhD student

wangxiaoyuan20121017@gmail.comhttps://orcid.org/0000-0003-0777-4861566605185007732-1150AstakhovSergey Yu.АстаховСергей ЮрьевичAstakhovSergey Yu.
Russian Federation

Dr. Sci. (Med.), professor

д-р мед. наук, профессор

Dr. Sci. (Med.), professor

astakhov73@mail.ruhttps://orcid.org/0000-0001-7807-90363132-9163PotemkinVitaly V.ПотемкинВиталий ВитальевичPotemkinVitaly V.
Russian Federation

Cand. Sci. (Med.)

канд. мед. наук

Cand. Sci. (Med.)

potem@inbox.ruPotemkinaAlbina R.ПотемкинаАльбина РашидовнаPotemkinaAlbina R.
Russian Federation

ophthalmologist

врач-офтальмолог

ophthalmologist

prinzabiyka@mail.ruhttps://orcid.org/0000-0001-8794-0457AnikinaLiliya K.АникинаЛилия КамилевнаAnikinaLiliya K.
Russian Federation

medical resident

ординатор

medical resident

lily-sai@yandex.ruPavlov First St. Petersburg State Medical UniversityПервый Санкт-Петербургский государственный медицинский университет им. академика И.П. ПавловаPavlov First St. Petersburg State Medical UniversityCity Multidiscipline Hospital No. 2Городская многопрофильная больница № 2City Multidiscipline Hospital No. 23009202114217262503202125042021Copyright ©; 2021, Wang X., Astakhov S.Y., Potemkin V.V., Potemkina A.R., Anikina L.K.Copyright ©; 2021, Ван С., Астахов C.Ю., Потемкин В.В., Потемкина А.Р., Аникина Л.К.Copyright ©; 2021, Wang X., Astakhov S., Potemkin V., Potemkina A., Anikina L.2021Wang X., Astakhov S.Y., Potemkin V.V., Potemkina A.R., Anikina L.K.Ван С., Астахов C.Ю., Потемкин В.В., Потемкина А.Р., Аникина Л.К.Wang X., Astakhov S., Potemkin V., Potemkina A., Anikina L.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/ov/article/view/64116

Background. Cataract is often associated with primary glaucoma. Prostaglandin analogues use is considered to be a risk factor for pseudophakic cystoid macular edema.

Purpose. To evaluate the effect of prostaglandin analogues and non-steroidal anti-inflammatory drops on the central retinal thickness and the incidence of pseudophakic cystoid macular edema after phacoemulsification with intraocular lens implantation in patients with primary open-angle glaucoma.

Materials and methods. 91 patients were enrolled in the study. 22 patients (22 eyes) were included in the first main group and 22 patients (22 eyes) were included in the second main groups. All patients in main groups had glaucoma and used prostaglandin analogues. 47 patients (57 eyes) without glaucoma were included in the control group. All patients were treated with topical antibiotics and steroids after phacoemulsification. Patients in the main second and in the control groups also received non-steroidal anti-inflammatory drops. The retinal thickness was measured by optical coherence tomography 2 weeks, 2 months and 6 months after the operation.

Results. After the operation, the foveal thickness in patients of the first and the second groups was increased, but it had returned to the preoperative level after 6 months in the first group and after 2 months in the second group. The retinal thickness in the fovea in the control group decreased after the surgery and it has been increasing gradually but did not achieve the preoperative value.

Conclusion. Prostaglandin analogues use after phacoemulsification with intraocular lens implantation does not affect the incidence of pseudophakic cystoid macular edema. Prescribing non-steroidal anti-inflammatory drops after the surgery helps to achieve faster normalization of the central retinal thickness.

Цель. Оценка влияния применения аналогов простагландинов и нестероидных противовоспалительных средств на толщину сетчатки в фовеа и развитие псевдофакичного кистозного макулярного отека после факоэмульсификации с имплантацией интраокулярной линзы у больных первичной открытоугольной глаукомой.

Материалы и методы. В исследование включен 91 пациент. В первую и вторую основные группы вошли по 22 пациента (22 глаза), получающие аналоги простагландинов. В контрольную группу вошли 47 неглаукомных пациентов (57 глаз). Все пациенты получали после операции кортикостероиды и антибиотики, также пациенты второй основной и контрольной групп получали нестероидные противовоспалительные средства. Методом оптической когерентной томографии оценивали толщину центральной зоны сетчатки до операции, через 2 недели, 2 и 6 месяцев после операции.

Результаты. Толщина сетчатки в фовеа после факоэмульсификации в основных группах была увеличена и вернулась к исходным значениям через 6 месяцев в первой группе и через 2 месяца во второй, в контрольной группе - через 2 недели после операции была ниже дооперационных значений, затем постепенно возрастала, но не достигла исходного уровня.

Заключение. У больных, получающих аналоги простагландинов, после факоэмульсификации с имплантацией интраокулярной линзы псевдофакичный кистозный макулярный отек не выявлен. Применение нестероидных противовоспалительных средств в послеоперационном периоде стабилизирует толщину сетчатки и способствует ускорению ее нормализации.

目标: 评估前列腺素类似物和非甾体抗炎药对原发性开角型青光眼患者在进行超声乳化术并植入人工晶状体后的视网膜中央凹厚度和白内障术后囊性黄斑水肿发展的影响。

材料和方法: 共有91名患者被纳入研究。第一和第二观察组包括各22名应用前列腺素类似物的患者（22只眼睛）。对照组包括47名患者(57只眼睛)，不伴有青光眼。各组受试者术后都接受了皮质类固醇和抗生素，而第二组和对照组的患者还接受了非甾体类抗炎药。通过光学相干断层扫描来评估术前、术后2周、2个月和6个月视网膜中央区的厚度。

结果: 观察组中超声乳化术后视网膜中央凹的厚度增加，第一组在6个月后恢复到基线值，第二组在2个月后恢复到基线值，对照组在术后2周低于术前值，然后逐渐增加，但没有达到基线值。

结论: 在我们对应用前列腺素类似物患者进行超声乳化术和人工晶状体植入术后没有发现白内障术后囊性黄斑水肿。术后使用非甾体类抗炎药可以稳定视网膜的厚度，有助于恢复其正常厚度。

retinal thicknessfoveaphacoemulsificationprimary open-angle glaucomaprostaglandin analoguespseudophakic cystoids macular edemanon-steroidal anti-inflammatory dropsoptical coherence tomographyтолщина сетчаткифовеафакоэмульсификацияпервичная открытоугольная глаукомааналоги простагландиновпсевдофакичный кистозный макулярный отекнестероидные противовоспалительные средстваоптическая когерентная томография视网膜厚度中央凹超声乳化术原发性开角型青光眼前列腺素类似物白内障术后囊性黄斑水肿非甾体类抗炎药光学相干断层扫描Scholl S, Kirchhof J, Augustin AJ. Pathophysiology of macular edema. Ophthalmologica. 2010;224 Suppl 1:8–15. DOI: 10.1159/000315155Scholl S., Kirchhof J., Augustin A.J. Pathophysiology of macular edema // Ophthalmologica. 2010. Vol. 224, Suppl 1. P. 8–15. DOI: 10.1159/000315155Irvine SR. A newly defined vitreous syndrome following cataract surgery. Am J Ophthalmol. 1953;36(5):599–619. DOI: 10.1016/0002-9394(53)90302-xIrvine S.R. A newly defined vitreous syndrome following cataract surgery // Am J Ophthalmol. 1953. Vol. 36, No. 5. 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