Congenital hypertrophy of the retinal pigment epithelium (clinical cases)

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Abstract

Congenital hypertrophy of the retinal pigment epithelium is a benign pigmented formation on the globe fundus, which has a characteristic appearance during ophthalmoscopy and is not prone to significant growth as well as malignancy. Nevertheless, one of the forms of congenital hypertrophy of the retinal pigment epithelium is associated with familial adenomatous polyposis, therefore, for timely follow-up examination of patients, it is necessary to know the differential diagnostic criteria of various forms of this disease. The article presents three clinical cases and as well as summarizes information about various forms of congenital hypertrophy of the retinal pigment epithelium.

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About the authors

Aleksei A. Suetov

S.N. Fyodorov Eye Microsurgery Federal State Institution, Saint Petersburg Branch; State Scientific Research Test Institute of Military Medicine

Author for correspondence.
Email: ophtalm@mail.ru
ORCID iD: 0000-0002-8670-2964
SPIN-code: 4286-6100

MD, Cand. Sci. (Medicine)

Russian Federation, Saint Petersburg; Saint Petersburg

Taisiia A. Doktorova

S.N. Fyodorov Eye Microsurgery Federal State Institution, Saint Petersburg Branch; North-Western State Medical University named after I.I. Mechnikov

Email: taisiiadok@mail.ru
ORCID iD: 0000-0003-2162-4018
SPIN-code: 8921-9738

MD

Russian Federation, Saint Petersburg; Saint Petersburg

Anastasiya N. Panfilova

Ophthalmological center “Vision”

Email: panfilova@zrenie.spb.ru
ORCID iD: 0000-0002-8191-6090

MD

Russian Federation, Saint Petersburg

Tatyana Yu. Kostritsina

North-Western State Medical University named after I.I. Mechnikov

Email: melodovich@mail.ru
ORCID iD: 0009-0006-1172-5789

MD

Russian Federation, Saint Petersburg

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Supplementary files

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2. Fig. 1. Color fundus photography, fundus autofluorescence and structural OCT scan through the lesion of patient A with solitary congenital hypertrophy of the retinal pigment epithelium (explanations in the text)

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3. Fig. 2. Color fundus photography (montage) of patient B with multifocal congenital hypertrophy of the retinal pigment epithelium (explanations in the text)

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4. Fig. 3. Color fundus photography, fundus autofluorescence and structural OCT scan through the lesion of patient B with multifocal congenital hypertrophy of the retinal pigment epithelium (explanations in the text)

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5. Fig. 4. Color fundus photography and structural OCT scans of patient B with multifocal congenital hypertrophy of the retinal pigment epithelium: in the projection of a pigmented lesion there was lattice degeneration with vitreal traction (a), retinal tear (b) and local neuroepithelium detachment (с)

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6. Fig. 5. Color fundus photography (а, с), fundus autofluorescence (b) and structural OCT scan (d) through the lesion of patient V with multifocal congenital hypertrophy of the retinal pigment epithelium (white arrows — lesion borders, explanations in the text)

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7. Fig. 6. Color fundus photography (а, d) and structural OCT scans of patient V: choroidal neovascularization from a focus of multifocal congenital hypertrophy of retinal pigment epithelium (b) and serous neuroepithelial detachment in the fovea (е) before treatment and reduction of neovascular membrane (c) with regression of neuroepithelial detachment (f) 1 month after intravitreal injection of angiogenesis inhibitor

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