Ophthalmology Reports

Medical peer-reviewed quarterly journal published since 2008.

Publisher

Chief editor

About

Main publications of the journal are focused on key issues of modern ophthalmology: etiology and pathogenesis, epidemiology, clinical picture features, up-to-date methods of diagnosis, prevention, and treatment of eye diseases and of those of its adnexa.

The journal publishes original articles, scientific reviews, lectures, clinical case descriptions (presented by Russian and foreign authors), and informs about past congresses and conferences in Russia.

The journal is oriented toward practicing ophthalmologists, including ophthalmic surgeons, scientific and teaching staff of medical higher educational institutions, physicians in ophthalmology training, as well as for specialists of allied health specialties.

The journal’s mission:

  1. To integrate research results of Russian scientists and the rich clinical experience of practicing doctors in diagnosis, prevention, and treatment of eye diseases into the international scientific space; to be an international scientific platform for discussions and sharing experiences;
  2. To provide for ophthalmologists of the Russian Federation actual and high quality research and practice insights into most up-to-date treatment and prevention methods of eye diseases and of those of its adnexa.

Publications

  • in English, Russian, Chinese 
  • in hybrid access (subscription and Open Access with СС BY-NC-ND license)
  • with no obligatory APC for all authors

Indexation


Announcements More Announcements...

 

Report on the 29th White Nights International Ophthalmology Congress named after Professor Yu.S. Astakhov — 19th Congress of the All-Russian social organization “Association of ophthalmologists”

Posted: 14.07.2023

С 29 мая по 2 июня 2023 г. в Санкт-Петербурге проходил XXIX Международный офтальмологический конгресс «Белые ночи» имени профессора Ю.С. Астахова — 19-й Конгресс Общероссийской общественной организации «Ассоциация врачей-офтальмологов». Это ежегодное мероприятие, являющееся наиболее крупным не только для России, но и для всей Северной Европы, посвящено диагностике и лечению заболеваний органа зрения и проводится в соответствии с приказом Министерства здравоохранения нашей страны.


 

"Ophtalmology Reports" — the new parallel title of the journal to be used in citations and references

Posted: 14.11.2022

The journal has changed its parallel title in English to "Ophtalmology Reports" to ensure the uniqueness of the name among scientific journals with similar research fields.

Editorial team ask the authors to use the parallel title "Ophthalmology Reports" when citing published articles to indicate the journal correctly, even if the cited articles were published in earlier issues of the journal. This will allow not to lose the citations of the journal and better identify references.

All articles' publication imprint are kept unchanged, including DOI. Changing the parallel title is not associated with changes in ISSN and eISSN (remained the same) and does not change the scientometric indicators of the journal, but is intended to eliminate incorrect citation counting, which may occur when there are several different journals with the same title.


 

Current Issue

Open Access Open Access  Restricted Access Access granted  Restricted Access Subscription or Fee Access

Vol 17, No 1 (2024)

Cover Page

Full Issue

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Original researches

The influence of some general diseases for changes on the ocular surface after trabeculectomy
Аntonova А.V., Nikolaenko V.P., Brzheskiy V.V., Vuks A.J., Koskin S.A.
Abstract

BACKGROUND: By now, possible effects of diabetes mellitus and arterial hypertension on the ocular surface changes after trabeculectomy have not been evaluated.

AIM: Analysis of the effects of arterial hypertension therapy and diabetes mellitus on the ocular surface changes after trabeculectomy.

MATERIALS AND METHODS: The study group consisted of 443 patients, including those with arterial hypertension (179 patients), non insulin dependent compensated type 2 diabetes mellitus (25 patients) and their combination (53 persons), operated in 2016–2020 in the City Multifield Hospital No. 2, Saint-Petersburg, for primary open-angle noncompensated glaucoma and then observed for 6 to 24 months. The dynamics of ocular surface disease index (OSDI), tear film break-up time (TBUT), and amount of total tear production has been studied.

RESULTS: The probability of the trabeculectomy success did not depend on the concomitant comorbidity. In contrast to intraocular pressure, the criteria for subjective and objective assessment of the ocular surface state were not subject to such obvious changes. In diabetic patients, the studied criteria have not changed compared to the baseline.

CONCLUSIONS: The mentioned systemic diseases do not influence the state of the ocular surface in patients with glaucoma, and are not an independent risk factor for the failure of the IOP-lowering surgical procedure. The presence of diabetes mellitus prevents the accompanying a successful trabeculectomy regression of symptoms and clinical and functional signs of dry eye disease.

Ophthalmology Reports. 2024;17(1):7-20
pages 7-20 views
Comparative analysis of tabular and software methods of quantitative assessment of metamorphopsia
Shpak A.A., Zhuravlev A.S., Avakyan F.A., Kolesnik A.I., Kolesnik S.V., Avakyan A.A.
Abstract

BACKGROUND: Identifying and evaluating the severity of patients complaints of metamorphopsia is an important component of the pre- and postoperative management of patients with vitreomacular interface conditions. To diagnose metamorphopsia, the Amsler grid is used, which allows to detect changes, but does not allow to quantify them. The authors of this article have developed a special software program for quantitative evaluation of metamorphopsia.

AIM: The aim is to comparatively evaluate tabular and programmatic methods of metamorphopsia assessment.

MATERIALS AND METHODS: The study involved 36 patients (36 eyes) divided into two groups: “macular hole” (20 patients, 20 eyes) and “epiretinal fibrosis” (16 patients, 16 eyes). Quantitative assessment of metamorphopsia was performed by two methods: tabular — using printed tables, which are an analog of M-CHARTS, and software — using the developed computer program.

RESULTS: When comparing the integral parameters of the two methods using the Bland–Altman analysis, the results were highly comparable: the mean value of the difference between the PMs determined by the tabular and program methods was only –0.020°; the 95% confidence interval ranged from 0.277° to 0.235°, with 34 (94.4%) cases out of 36 falling within this range.

CONCLUSIONS: The program and tabular methods of metamorphopsia examination are interchangeable and provide reasonably accurate quantification of metamorphopsia. The developed program is available on-line (https://mntk.ru/specialists/nauka-sotr/diag_meta/) and can be recommended for widespread clinical use.

Ophthalmology Reports. 2024;17(1):21-28
pages 21-28 views
The influence of post-COVID-19 syndrome on microcirculation of the optic nerve head among patients with primary open-angle glaucoma
Petrov S.Y., Okhotsimskaya T.D., Filippova O.M., Markelova O.I.
Abstract

BACKGROUND: Glaucoma is one of the leading causes of blindness in the world. This is a multifactorial ophthalmopathology, which also results from impaired microcirculation in the optic nerve. One of the diseases affecting ocular blood flow is acute coronavirus infection (COVID-19).

AIM: The aim of this study is the assessment of blood flow parameters of the optic nerve head in patients with primary open-angle glaucoma (POAG) against the background of post-COVID-19 syndrome using laser speckle flowgraphy.

MATERIALS AND METHODS: The study included 40 patients with advanced stage primary open-angle glaucoma who had COVID-19 within the previous 3 months. Patients were divided into 2 subgroups depending on the severity of the disease. The comparison group consisted of 20 individuals with an advanced stage of primary open-angle glaucoma who did not have COVID-19. All subjects were over 60 years old and had normal blood pressure parameters. Optic nerve head blood flow was measured using the LSFG-NAVI device (Japan) and assessed by LSFG Analyzer software. MBR parameters (MA, MV and MT), as well as pulse wave indicators (Skew, BOS, BOT, RR, FR, FAI, ATI and RI) were analyzed.

RESULTS: The most significant decrease was found for the MV and MT parameters, reflecting the blood flow in large vessels and the microvasculature of the optic disc. MV decrease by 20%, MT — by 23%, MA — by 16% were noted, as well as pulse wave parameter changes, in patients with an advanced stage of primary open-angle glaucoma, post-COVID syndrome after moderate COVID-19 compared with patients with an advanced stage of primary open-angle glaucoma who did not have COVID-19 (p ≤ 0.05).

CONCLUSIONS: Laser speckle flowgraphy allows rapid and effective assessment of ocular blood flow. Parameters estimated at the examination may be considered as new biomarkers for the detection and evaluation of vascular diseases.

Ophthalmology Reports. 2024;17(1):29-38
pages 29-38 views
Comparative analysis of the anterior chamber changes after intravitreal injections of aflibercept and brolucizumab
Andreeva Y.S., Alkharki L., Budzinskaya M.V.
Abstract

BACKGROUND: Currently, the information is insufficient about the effect of multiple intravitreal injections (IVI) of brolucizumab in comparison with aflibercept on the parameters of iridolenticular diaphragm.

AIM: The aim of this study is using optical coherence tomography of the anterior segment (AS-OCT) to evaluate changes in the parameters of the anterior chamber in patients with multiple intravitreal injections of aflibercept and brolucizumab in the treatment of the neovascular form of age-related macular degeneration (nAMD).

MATERIALS AND METHODS: In total, 60 patients (60 eyes) were included into the study. The follow-up period duration was 12 months. Patients were divided into 2 groups: group 1 — 30 patients receiving intravitreal injections of aflibercept, group 2 — 30 patients receiving intravitreal injections of brolucizumab. Using a Revo NX tomograph, AS-OCT was performed, the depth of the anterior chamber and the dimensions of the anterior chamber angle were examined. The measurement was performed before intravitreal injections, one month after the first, one month after the third intravitreal injections, and one year after treatment.

RESULTS: In both groups, a shift of the iridolenticular diaphragm was noted according to AS-OCT data — a significant decrease in depth of the anterior chamber, anterior chamber angle parameters before treatment and after 4 months of treatment, as well as after a year of treatment. In group 1, in contrast to group 2, a greater number of intravitreal injections led to a greater decrease in the depth of the anterior chamber (rxy = 0.415, p = 0.02) and to a greater narrowing of the anterior chamber angle on the nasal and temporal sides (rxy = 0.37, p = 0.049 and rxy = 0.424, p = 0.02, respectively).

CONCLUSIONS: For the first time, changes of the anterior chamber of the eye were determined against the background of multiple intravitreal injections of aflibercept and brolucizumab in the treatment of the neovascular form of age-related macular degeneration using AS-OCT.

Ophthalmology Reports. 2024;17(1):39-50
pages 39-50 views

Experimental trials

Standardized Russian reading chart for assessing reading parameters
Stepanets I.R., Koskin S.A., Kulikov A.N.
Abstract

BACKGROUND: A number of charts based on checking reading parameters are increasingly being used to assess visual functions. These charts are standardized, translated into many languages. The development of a Russian chart based on international standards and the determination of age norms of clinical reading parameters will allow it to be used for a more accurate assessment of the dynamics of diseases and treatment results.

AIM: The aim is to determine the normal reading parameters in patients of different age groups.

MATERIALS AND METHODS: Based on international standards, two Russian charts have been developed to study reading parameters. Reading parameters were determined during one session in 135 subjects, divided into 3 groups: I — 18–39 years, II — 40–59 years, and III — 60–81 years. Three main parameters were studied: maximum reading speed, critical print size, and reading acuity (RA).

RESULTS: As a result of the study, age norms for basic reading parameters were determined. Maximum reading speed in group I was 192.5 ± 1.2, in group II — 180.6 ± 1.1 and in group III — 168.9 ± 0.8 words/min. Critical print size in group I was 0.14 ± 0.01, in group II — 0.24 ± 0.01, and in group III — 0.36 ± 0.01 logMAR. The reading acuity in group I was 0.009 ± 0.006, in group II — 0.075 ± 0.04, in group III — 0.143 ± 0.005 logMAR. The differences between the studied parameters in groups I/II, I/III and II/III were statistically significant (p < 0.05).

CONCLUSIONS: The indicators of reading parameters obtained during the study can be used as approximate age norms.

Ophthalmology Reports. 2024;17(1):51-62
pages 51-62 views

Problems of ophthalmic pharmacology

Possibilities of reparative therapy in the treatment of patients with xerotic changes in the cornea
Brzheskiy V.V., Bobryshev V.A.
Abstract

In recent years, in the treatment of patients with dry eye syndrome, drugs that, along with moisturizing, also have specific metabolic properties, due to the additional medicinal ingredients contained in them, deserve more and more attention. The article presents comparative data on the preparations of “artificial tears” and so-called keratoprotectors registered in Russia. In addition, a number of experimental and clinical studies by domestic authors evaluating the pharmacological and clinical effect of the new keratoprotector SPHERO®oko were reviewed. Much attention is also paid to the consideration of the original direction of SPHERO®oko application — its introduction into the corneal stroma (together with a dye) for cosmetic and functional keratopigmentation in the presence of extensive iris defects. The authors of the literature review, taking into account the results of numerous experimental studies and some clinical observations, believe that the use of SPHERO®oko has quite great opportunities in the complex treatment of xerotic changes of the cornea and conjunctiva. At the same time, it is of interest to continue the research on the possibilities of intrastromal administration of colored SPHERO®oko for keratopigmentation in the presence of extensive iris defects.

Ophthalmology Reports. 2024;17(1):63-70
pages 63-70 views

Case reports

Keratoprosthetics as a visual rehabilitation method in patients with graft-versus-host disease
Belov D.F., Nikolaenko V.P., Petukhov V.P.
Abstract

The article is concerned with the treatment of a patient with allogeneic hematopoietic stem cell transplantation (HSCT) complicated by graft-versus-host disease with severe ocular manifestations. Hematopoietic stem cell transplantation is the standard therapy for a number of hemoblastoses and hereditary blood diseases, ensures the restoration of the immune system, however, in 40–60% of cases it is complicated by the development of graft-versus-host disease, with a five-year survival rate of no more than 40%. Patient S., 22 years old, was admitted to the ophthalmological center of Saint Petersburg Multifield Hospital No. 2 in 2019 with a diagnosis of “Acute keratitis, corneal ulcer of both eyes”. History of hematopoietic stem cell transplantation in 2018, complicated by graft-versus-host disease with multiorgan damage development was present. In total during the period 2019–2022, 7 tectonic keratoplasties were performed on both eyes, as well as penetrating keratoplasty on the left eye. After inflammation setback and left eye vascularized corneal leukoma formed, in December 2022, the first stage of keratoprosthetics (installation of the support element) was performed, and in May 2023, the second stage (implantation of the optical cylinder) took place. Visual acuity in one month after the implantation of the keratoprosthesis increased from light perception to 20/100, no correction possible. The use of “classical” methods of corneal ulcer perforation treatment in patients with graft-versus-host disease is ineffective due to the severe ocular surface xerosis, and keratoprosthetics seems to be the only effective method for restoring visual functions.

Ophthalmology Reports. 2024;17(1):71-78
pages 71-78 views
Acute retinal pigment epitheliitis (clinical cases)
Doktorova T.A., Panfilova A.N., Suetov A.A.
Abstract

Acute retinal pigment epitheliitis (Krill’s disease) is a rare idiopathic self-limiting inflammatory macular disease. The article presents the results of multimodal dynamic imaging in 2 patients with acute retinal pigment epitheliitis, including, for the first time ever, the results of optical coherence tomography-angiography, suggesting the pathogenetic significance of changes in perfusion in the choriocapillaris for the development of this disease.

Ophthalmology Reports. 2024;17(1):79-88
pages 79-88 views

Reviews

Chemical analysis of meibum composition of type 2 diabetes mellitus
Safonova T.N., Zaitseva G.V., Timoshenkova E.I.
Abstract

The meibomian glands, by producing a lipid-rich secretion (meibum), are involved in the formation of the lipid layer of the tear film, preventing its evaporation and ensuring the maintenance of ocular surface homeostasis. Meibomian gland dysfunction is a common disease. Numerous clinical studies have pointed to involvement of the meibomian glands in a number of systemic diseases, including diabetes mellitus. Hyperglycemia provokes the development of oxidative stress and metabolic disorders, leading to changes in the anatomical and functional state of the breast, which affects the qualitative and quantitative composition of the secretion. Instrumental methods of meibomian glands assessment reflect their morphofunctional state, and chemo-analytical study of the meibum can serve as a reflection of anatomical and physiological changes of the glands. Proteomic technologies are promising methods for studying the composition of the meibomian glands secretion, allowing us to determine the patterns of changes in the chemical composition of the meibum in patients with diabetes mellitus to detect early signs of the disease and prevent the development of complications.

Ophthalmology Reports. 2024;17(1):89-102
pages 89-102 views
The role of artificial intelligence in modern ophthalmology
Mamedova S.S., Karimova A.I., Galieva A.F., Malkhanova M.A., Polyankina S.S., Kuchumova A.I., Tarasova Y.Y., Tsuan D.U., Klets O.V., Gerbutova V.N., Olenichev A.V., Ushakova E.O., Minnikhalilova A.K.
Abstract

Currently, artificial intelligence is actively being introduced into various spheres of life, and medicine is no exception. In ophthalmology, the use of artificial intelligence is very promising, given that the diagnosis and therapeutic monitoring of eye diseases often depend heavily on the correct interpretation of images. The use of artificial intelligence in ophthalmology focuses on eye diseases that lead to vision loss, such as age-related macular degeneration, diabetic retinopathy, glaucoma and cataract. Over the past few years, artificial intelligence has reached tremendous successes in the practice of ophthalmology. Many studies have shown that artificial intelligence performance is equal to and even exceeds the capabilities of ophthalmologists in many diagnostic and prognostic tasks. However, there is still a lot of work to be done before introducing artificial intelligence into routine clinical practice. Issues such as real-world performance, generalizability, and interpretability of artificial intelligence systems are still poorly understood and will require more attention in future research. Most artificial intelligence-based systems are used in developed countries, and some require further study. High costs and a shortage in doctors and equipment in some regions of the Russian Federation and rural areas make it difficult to screen for eye diseases. Although the field of artificial intelligence is underdeveloped, we hope that artificial intelligence will play an important role in the future of ophthalmology by making healthcare more efficient, accurate and accessible, especially in regions where staffing problems exist.

Ophthalmology Reports. 2024;17(1):103-113
pages 103-113 views


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies