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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">I.P. Pavlov Russian Medical Biological Herald</journal-id><journal-title-group><journal-title xml:lang="en">I.P. Pavlov Russian Medical Biological Herald</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский медико-биологический вестник имени академика И.П. Павлова</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0204-3475</issn><issn publication-format="electronic">2500-2546</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">34021</article-id><article-id pub-id-type="doi">10.23888/PAVLOVJ2020284514-524</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case report</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>Clinical reports</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">A patient with heartburn practicing self-treatment, on an outpatient visit</article-title><trans-title-group xml:lang="ru"><trans-title>На амбулаторном приеме пациент с изжогой, занимающийся самолечением</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title/></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1757-0774</contrib-id><contrib-id contrib-id-type="researcherid">AAN-1402-2020</contrib-id><contrib-id contrib-id-type="spin">2127-5771</contrib-id><name-alternatives><name xml:lang="en"><surname>Krylova</surname><given-names>Irina A.</given-names></name><name xml:lang="ru"><surname>Крылова</surname><given-names>Ирина Александровна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Associate Professor of the Department of Family Medicine</p></bio><bio xml:lang="ru"><p>к.м.н., доцент кафедры семейной медицины</p></bio><email>raznoe.2009@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7807-083X</contrib-id><contrib-id contrib-id-type="researcherid">AAN-1405-2020</contrib-id><contrib-id contrib-id-type="spin">4790-7861</contrib-id><name-alternatives><name xml:lang="en"><surname>Matʼkova</surname><given-names>Irina N.</given-names></name><name xml:lang="ru"><surname>Матькова</surname><given-names>Ирина Николаевна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Head of the General Medical Practice Department</p></bio><bio xml:lang="ru"><p>зав. отделением общей врачебной практики</p></bio><email>kmukenova@inbox.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samara State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО Самарский государственный медицинский университет Минздрава России</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Medical and Sanitary Department №2</institution></aff><aff><institution xml:lang="ru">ГБУЗ СО Медико-санитарная часть №2</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2020</year></pub-date><volume>28</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>514</fpage><lpage>524</lpage><history><date date-type="received" iso-8601-date="2020-05-08"><day>08</day><month>05</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2020-08-04"><day>04</day><month>08</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, OOO "Эко-Вектор"</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2021, Eco-Vector</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">OOO "Эко-Вектор"</copyright-holder><copyright-holder xml:lang="zh">Eco-Vector</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/pavlovj/article/view/34021">https://journals.eco-vector.com/pavlovj/article/view/34021</self-uri><abstract xml:lang="en"><p>More than 40% of adult Russians periodically feel heartburn. Progression of the disease leads to a number of complications shortening patients’ life. However, patients try to cope with problems by themselves, without receiving adequate early treatment. Only when the life quality worsens, which evidences progression of the disease, they turn to a doctor. Success of treatment depends on the level of the patient’s compliance, life-long complete and regular adherence to treatment recommended by the doctor. With this, an outpatient with a chronic disease should provide the most part of the required medical service by himself. However, patients often change the therapeutic measures on their own impairing the result of treatment.</p> <p>The given below clinical case of patient Zh., 38 years old, with heartburn and existing risk factors of other non-infectious diseases is a typical illustration of the interaction of a <italic>general practitioner</italic> and an outpatient practicing self-treatment. Facing the situation of necessary regular medical monitoring and life-long complex intervention, the patient uses only easy-to-follow doctor’s recommendations and understandable for him treatment methods.</p> <p><bold><italic>Conclusion</italic></bold>. On an example of this clinical case, a possible necessary and sufficient plan o f informing outpatient is presented containing information of the tactics of his behavior for full realization of medical recommendations. For successful adaptation of an outpatient with chronic health problems and harmonic attitude to the disease, the doctor should be maximally specific about necessary and adequate measures for correction of the patient’s behavior for the fullest realization of therapeutic recommendations. Recommendations should contain understandable information of basic medicinal and non-medicinal therapy in remission (the essential vital stereotypes – work-rest regime, type and regime of nutrition, physical activity and principles of monitoring the condition), of signs of exacerbation and methods of therapy «on demand» and also information of symptoms requiring urgent assistance, of risks of self-treatment, of visiting the doctor in case new or vivid symptoms appear, of the dates of planned examinations by the doctor. These recommendations are not applicable to patients with severe and manifest course of the disease, with disharmonic attitude to the disease, and in case of inadequate organization capacities and low compliance of the patient.</p></abstract><trans-abstract xml:lang="ru"><p>Свыше 40% взрослых россиян периодически испытывают изжогу. Прогрессирование болезни приводит к ряду осложнений, сокращающих продолжительность жизни пациентов. Однако, пациенты стараются справиться самостоятельно, не получая раннего адекватного лечения. Только при ухудшении качества жизни, свидетельствующем о прогрессировании заболевания, они обращаются к врачу. Успех лечения зависит от уровня комплаентности пациента, полного и регулярного соблюдения рекомендованного врачом лечения на протяжении всей жизни. При этом, большую часть необходимого ему медицинского обслуживания амбулаторный пациент с хроническим заболеванием должен обеспечивать себе сам. Однако, пациенты часто самостоятельно вносят изменения в лечебные мероприятия, ухудшая результат.</p> <p>Представленный клинический случай пациентки Ж., 38 лет с изжогой и наличием факторов риска других неинфекционных заболеваний является типичной иллюстрацией взаимодействия <italic>врача общей практики</italic> и амбулаторного пациента, занимающегося самолечением. Сталкиваясь с ситуацией необходимости регулярного медицинского мониторинга и пожизненного комплексного вмешательства, пациент использует только выполнимые для него рекомендации врача и понятные ему методы самолечения.</p> <p><bold><italic>Заключение. </italic></bold>На примере данного клинического случая представлен возможный необходимый и достаточный план информирования амбулаторного пациента, содержащий сведения о тактике его поведения для полной реализации врачебных рекомендаций. Для успешной адаптации пациента с хроническими проблемами здоровья и гармоничным отношением к заболеванию необходима максимальная конкретизация врачом необходимых и достаточных мер коррекции поведения пациента для наиболее полной реализации врачебных рекомендаций. Рекомендации должны содержать доступную информацию о базисной медикаментозной и немедикаментозной терапии в ремиссии (нужные жизненные стереотипы – режим труда и отдыха, режим и характер питания, физическая активность и принципы мониторинга состояния), о признаках обострения и методах «терапии по требованию», о рисках, связанных с прогрессированием заболевания и факторами риска других заболеваний, о симптомах, требующих неотложной помощи; о рисках при применении самолечения, о явке к врачу при появлении новых или ярко выраженных симптомов, о сроках плановых осмотров врача. Данные рекомендации не применимы к пациентам с тяжелым и манифестирующим течением заболевания, дисгармоничной внутренней картиной заболевания, при неадекватных организационных возможностях пациента и низком комплаенсе.</p></trans-abstract><trans-abstract xml:lang="zh"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>heartburn</kwd><kwd>an outpatient</kwd><kwd>compliance</kwd><kwd>self-treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>изжога</kwd><kwd>амбулаторный пациент</kwd><kwd>комплаенс</kwd><kwd>самолечение</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Drozdov VN, Serebrova SYu, Rykova SM, et al.; Shikh EV, editor. Gastroezofageal’naya reflyuksnaya bolezn’: klinicheskiye proyavleniya, medikamentoznaya terapiya. Moscow: GEOTAR-Media; 2019 (In Russ).</mixed-citation><mixed-citation xml:lang="ru">Дроздов В.Н., Сереброва С.Ю., Рыкова С.М., и др.; Ших Е.В., ред. Гастроэзофагеальная рефлюксная болезнь: клинические проявления, медикаментозная терапия. М.: ГЕОТАР-Медиа; 2019.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Lazebnik LB, Masharova AA, Bordin DS, et al. Results of a multicenter trial «Epidemiology of gastroesophageal reflux disease in Russia» (MEGRE). Terapevticheskii Arkhiv. 2011;83(1):45-50. (In Russ).</mixed-citation><mixed-citation xml:lang="ru">Лазебник Л.В., Машарова А.А., Бордин Д.С., и др. Результаты мультицентрового исследования «Эпидемиология гастроэзофагеальной рефлюксной болезни в России» (МЭГРЕ) // Терапевтический архив. 2011. Т. 83, №1. С. 45-50.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Hunt R, Armstrong D, Katelaris P, et al.; World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease. Journal of Clinical Gastroenterology. 2017; 51(6):467-78. doi:10.1097/MCG.0000000000000854</mixed-citation><mixed-citation xml:lang="ru">Hunt R., Armstrong D., Katelaris P., et al. World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease // Journal of Clinical Gastroenterology. 2017. Vol. 51, №6. P. 467-478. doi:10.1097/MCG.0000000000000854</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Kaybysheva VO, Kucheryavy YuA, Trukhmanov AS, et al. Results of multicenter observation study on application of international questionnaire GerdQ for diagnostics of gastroesophageal reflux disease. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2013;(5):15-23. (In Russ).</mixed-citation><mixed-citation xml:lang="ru">Кайбышева В.О., Кучерявый Ю.А., Трухманов А.С., и др. Результаты многоцентрового наблюдательного исследования по применению международного опросника GerdQ для диагностики гастроэзофагеальной рефлюксной болезни // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2013. №5. С. 15-23.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">de Bortoli N, Guidi G, Martinucci I, et al. Voluntary and controlled weight loss can reduce symptoms and proton pump inhibitor use and dosage in patients with gastroesophageal reflux disease: a comparative study. Diseases of the Esophagus. 2016;29(2):197-204. doi:10.1111/dote.12319</mixed-citation><mixed-citation xml:lang="ru">de Bortoli N., Guidi G., Martinucci I., et al. Voluntary and controlled weight loss can reduce symptoms and proton pump inhibitor use and dosage in patients with gastroesophageal reflux disease: a comparative study // Diseases of the Esophagus. 2016. Vol. 29, №2. P. 197-204. doi:10.1111/dote.12319</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Goh KL. Changing epidemiology of gastroesophageal reflux disease in the Asian-Pacific region: an overview. Journal of Gastroenterology and Hepatology. 2004;19(3):S22-5. doi:10.1111/j.1440-1746.2004.03591.x</mixed-citation><mixed-citation xml:lang="ru">Goh K.L. Changing epidemiology of gastroesophageal reflux disease in the Asian-Pacific region: an overview // Journal of Gastroenterology and Hepatology. 2004. Vol. 19, №3. P. S22-S25. doi:10.1111/j.1440-1746.2004.03591.x</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Lagergren J, Bergström R, Nyrén O. Association between body mass and adenocarcinoma of the esophagus and gastric cardia. Annals of Internal Medicine. 1999;130(11):883-90. doi:10.7326/003-4819-130-11-199906010-00003</mixed-citation><mixed-citation xml:lang="ru">Lagergren J., Bergström R., Nyrén O. Association between body mass and adenocarcinoma of the esophagus and gastric cardia // Annals of Internal Medicine. 1999. Vol. 130, №11. P. 883-890. doi:10.7326/003-4819-130-11-199906010-00003</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Person E, Rife C, Freeman J, et al. A novel sleep positioning device reduces gastroesophageal reflux: a randomized controlled trial. Journal of Clinical Gastroenterology. 2015;49(8):655-9. doi:10.1097/ MCG.0000000000000359</mixed-citation><mixed-citation xml:lang="ru">Person E., Rife C., Freeman J., et al. A novel sleep positioning device reduces gastroesophageal reflux: a randomized controlled trial // Journal of Clinical Gastroenterology. 2015. Vol. 49, №8. P. 655-659. doi:10.1097/MCG.0000000000000359</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">PRAC recommends restricting use of domperidone. Available at: https://www.ema.europa.eu/en/documents/press-release/prac-recommends-restricting-use-domperidone_en.pdf. Accessed: 2020 May 5.</mixed-citation><mixed-citation xml:lang="ru">PRAC recommends restricting use of domperidone. Доступно по: https://www.ema.europa.eu/en/docu-ments/press-release/prac-recommends-restricting-use-domperidone_en.pdf. Ссылка активна на 5 мая 2020.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">European Medicines Agency recommends changes to the use of metoclopramide. Available at: https:// www.ema.europa.eu/en/documents/press-release/european-medicines-agency-recommends-changes-use-metoclopramide_en.pdf. Accessed: 2020 May 5.</mixed-citation><mixed-citation xml:lang="ru">European Medicines Agency recommends changes to the use of metoclopramide. Доступно по: https://www.ema.europa.eu/en/documents/press-release/european-medicines-agency-recommends-changes-use-metoclopramide_en.pdf. Ссылка активна на 5 мая 2020.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Movshovich BL. Ambulatornaya meditsina: prakticheskoye rukovodstvo dlya vrachey pervichnogo zvena zdravookhraneniya. Moscow: MIA; 2010. (In Russ).</mixed-citation><mixed-citation xml:lang="ru">Мовшович Б.Л. Амбулаторная медицина: практическое руководство для врачей первичного звена здравоохранения. М.: МИА; 2010.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. The American Journal of Gastroenterology. 2013;108(3):308-29. doi:10.1038/ajg.2012.444</mixed-citation><mixed-citation xml:lang="ru">Katz P.O., Gerson L.B., Vela M.F. Guidelines for the diagnosis and management of gastroesophageal reflux disease // The American Journal of Gastroenterology. 2013. Vol. 108, №3. P. 308-329. doi:10.1038/ajg.2012.444</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Flameling RD, Numans ME, ter Linde J, et al. Different characteristics of patients with gastrooesophageal reflux disease on their path through health-care: a population follow-up study. European Journal of Gastroenterology &amp; Hepatology. 2010;22(5): 578-82. doi:10.1097/MEG.0b013e328335638c</mixed-citation><mixed-citation xml:lang="ru">Flameling R.D., Numans M.E., ter Linde J., et al. Different characteristics of patients with gastrooesophageal reflux disease on their path through healthcare: a population followup study // European Journal of Gastroenterology &amp; Hepatology. 2010. Vol. 22, №5. P. 578-582. doi:10.1097/MEG.0b013e328335638c</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">Kvarnström K, Airaksinen M, Liira H. Barriers and facilitators to medication adherence: a qualitative study with general practitioners. BMJ Open. 2018; 8(1):e015332. doi:10.1136/bmjopen-2016-015332</mixed-citation><mixed-citation xml:lang="ru">Kvarnström K., Airaksinen M., Liira H. Barriers and facilitators to medication adherence: a qualitative study with general practitioners // BMJ Open. 2018. Vol. 8, №1. P. e015332. doi:10.1136/bmjopen-2016-015332</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Webber D, Guo Z, Mann S. Self-Care in health: we can define it, but should we also measure it? Self Care. 2013;4(5):101-6.</mixed-citation><mixed-citation xml:lang="ru">Webber D., Guo Z., Mann S. Selfcare in health: we can define it, but should we also measure it? // Self Care. 2013. Vol. 4, №5. Р. 101-106.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">Kickbusch I. A Game Change in Global Health: The Best Is Yet to Come. Public Health Reviews. 2014;35(1). doi:10.1007/BF03391687</mixed-citation><mixed-citation xml:lang="ru">Kickbusch I. A Game Change in Global Health: The Best Is Yet to Come // Public Health Reviews. 2014. Vol. 35, №1. doi:10.1007/BF03391687</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">Durand H, Casey M, Glynn LG, et al. A qualitative comparison of high and low adherers with apparent treatment-resistant hypertension. Psychology, Health &amp; Medicine. 2020;25(1):64-77. doi:10.1080/13548 506.2019.1619788</mixed-citation><mixed-citation xml:lang="ru">Durand H., Casey M., Glynn L.G., et al. A qualitative comparison of high and low adherers with apparent treatmentresistant hypertension // Psychology, Health &amp; Medicine. 2020. Vol. 25, №1. P. 64-77. doi:10.1080/13548506.2019.1619788</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">Ferroni E, Casotto V, Pigato M, et al. Patient and General Practitioner characteristics influencing the management of non-insulin-treated diabetes mellitus: A cross-sectional study in Italy. Diabetes Research and Clinical Practice. 2016;116:192-201. doi:10.1016/j.diabres.2016.04.038</mixed-citation><mixed-citation xml:lang="ru">Ferroni E., Casotto V., Pigato M., et al. Patient and General Practitioner characteristics influencing the management of non-insulin-treated diabetes mellitus: A crosssectional study in Italy // Diabetes Research and Clinical Practice. 2016. Vol. 116. P. 192-201. doi:10.1016/j.diabres.2016.04.038</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">Krylova IA. Sovershenstvovaniye profilakticheskoy pomoshchi ambulatornym patsiyentam na osnove rezul’tatov psikhologicheskogo issledovaniya. Cardio-vascular Therapy and Prevention. 2017;16(suppl 3):165-6. (In Russ).</mixed-citation><mixed-citation xml:lang="ru">Крылова И.А. Совершенствование профилактической помощи амбулаторным пациентам на основе результатов психологического исследования // Кардиоваскулярная терапия и профилактика. 2017. Т. 16, Прил. 3. С. 165-166.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">Znyk M, Polańska K, Wojtysiak P, et al. Predictors o Counselling Related to Healthy Lifestyle Carried Out By a General Practitioner. International Journal of Environmental Research and Public Health. 2019;16(22):4475. doi:10.3390/ijerph16224475</mixed-citation><mixed-citation xml:lang="ru">Znyk M., Polańska K., Wojtysiak P., et al. Predictors o Counselling Related to Healthy Lifestyle Carried Out By a General Practitioner // International Journal of Environmental Research and Public Health. 2019. Vol. 16, №22. P. 4475. doi:10.3390/ijerph16224475</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">Sheikh I, Waghray A, Waghray N, et al. Consumer use of over-the-counter proton pump inhibitors in patients with gastroesophageal reflux disease. The American Journal of Gastroenterology. 2014; 109 (6):789-94. doi:10.1038/ajg.2013.421</mixed-citation><mixed-citation xml:lang="ru">Sheikh I., Waghray A., Waghray N., et al. Consumer use of over-the-counter proton pump inhibitors in patients with gastroesophageal reflux disease // The American Journal of Gastroenterology. 2014. Vol. 109, №6. P. 789-794. doi:10.1038/ajg.2013.421</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">Hayden CW, Bernstein CN, Hall RA, et al. Usage of Supplemental Alternative Medicine by Community-Based Patients with Gastroesophageal Reflux Disease (GERD). Digestive Diseases and Sciences. 2002;47(1):1-8. doi:10.1023/a:1013264730992</mixed-citation><mixed-citation xml:lang="ru">Hayden C.W., Bernstein C.N., Hall R.A., et al. Usage of Supplemental Alternative Medicine by Community-Based Patients with Gastroesophageal Reflux Disease (GERD) // Digestive Diseases and Sciences. 2002. Vol. 47, №1. P. 1-8. doi:10.1023/a:1013264730992</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">Luriya RA. Vnutrennyaya kartina bolezni i iatrogennyye zabolevaniya. Moscow: Meditsina; 1977. (In Russ).</mixed-citation><mixed-citation xml:lang="ru">Лурия Р.А. Внутренняя картина болезни и иатрогенные заболевания. М.: Медицина; 1977.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">Tadjiev IYa, Belostotsky AV, Kamynina IN. The development of general practitioner practice in the Russian Federation. Problems of Social Hygiene, Public Health and History of Medicine. 2018;26 (1):20-5. (In Russ). doi:10.1016/0869-866X-2018-26-1-20-25</mixed-citation><mixed-citation xml:lang="ru">Таджиев И.Ю., Белостоцкий А.В., Камынина И.Н. Развитие общей врачебной практики в Российской Федерации // Проблемы социальной гигиены, здравоохранения и истории медицины. 2018. Т. 26, №1. С. 20-25. doi:10.1016/0869-866X-2018-26-1-20-25</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">Poynard T. [Role and limits of self-medication in the therapeutic strategy of gastroesophageal reflux in adults]. Gastroenterologie Clinique et Biologique. 1999;23(1 Pt 2):S176-9.</mixed-citation><mixed-citation xml:lang="ru">Poynard T. [Role and limits of selfmedication in the therapeutic strategy of gastroesophageal reflux in adults] // Gastroenterologie Clinique et Biologique. 1999. Vol. 23, №1. Part 2. P. S176-S179.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
