I.P. Pavlov Russian Medical Biological HeraldI.P. Pavlov Russian Medical Biological Herald0204-34752500-2546Eco-Vector454910.17816/PAVLOVJ2013424-28Research ArticleMorpholology of immune system of offspring after stimulation of maternal immune system in early pregnancy15122013214242828102016Copyright © 2013, Yaglova N.V., Obernikhin S.S.2013Stimulation of maternal immune system in early pregnancy with Concanavalin A, a T-cell mitogen, prior to formation of fetal immune system impairs development of the offspring’s spleen and thymus. Our findings demonstrate that short-term exposure of pregnant murine dams to Concanavalin A, leads to retardation of postnatal development of offspring’s spleen and reduction of lymphocytes count in thymus medulla and accelerated formation of thymic corpuscles.thymusspleenprenatal exposureconcanavalin Aтимусселезенкаконканавалин А[Болезни вилочковой железы / В.П. Харченко [и др.]. - М.: Триада-Х, 1998. - 231 с.][Динамика морфофункциональных изменений органов иммунной системы мышей Ba1b/c при экспериментальном гепатите / С.С. Обернихин [и др.] // Бюллетень экспериментальной биологии и медицины. - 2006. - Т. 141, №4. - С. 451-454.][Ярилин А.А. Цитокины в тимусе. Биологическая активность и функции цитокинов в тимусе / А. Ярилин // Цитокины и воспаление. - 2003. - Т. 2, №2. - С. 3-11.][Ce11 death and phagocytosis of haematopoietic elements at the onset of haemato-poiesis in the mouse sp1een: an u1trastructural study / K. Sasaki [et al.] // J. Anat. - 1993. - Vol. 183. - P. 113-120.][Gordon J. Mechanisms of thymus organogenesis and morphogenesis / J. Gordon, N. Manley // Development. - 2011. -Vol. 138. - P. 3865-3878.][Involvement of IL-10, an antiinflammatory cytokine in murine liver injury induced by Concanavalin A / M. Kato [et al.] // Hepatol. Res. - 2001. -Vol. 20, №2. - P. 232-243.][Maternal immune status in pregnancy is related to offspring’s immune responses and atopy risk / G. Herberth [et al.] // Allergy. -2011. - Vol. 66, №8. - P. 1065-1074.][Prenatal programming of the innate immune response following in utero exposure to inflammation: a sexually dimorphic process? / N. Hodyl [et al.] // Expert Review of clinical immunology. - 2011. - Vol. 7, №5. - P. 579-592.]