I.P. Pavlov Russian Medical Biological HeraldI.P. Pavlov Russian Medical Biological Herald0204-34752500-2546Eco-Vector456610.17816/PAVLOVJ20134139-142Research ArticleMatrix metalloproteinase-9 as a biomarker of poag1512201321413914228102016Copyright © 2013, Sokolov V.A., Levanova O.N., Nikiforov A.A.2013Diagnosis of primary open angle glaucoma (POAG) early stages of the pathological process remains a difficult task, even for experienced ophthalmologists. This work is devoted to the study of matrix metalloproteinase-9 (MMP-9) in lacrimal fluid of patients with POAG as a biomarker of this disease. Revealed a significantly higher concentration of MMP-9 in a lacrimal fluid in patients with glaucoma, at the initial stage of the pathological process. Dependence between levels of MMP-9 and stages of the pathological process has been established.matrix metalloproteinase-9primary otkratougolnaya glaucomalachrymalfluidматриксная металлопротеиназа-9первичная открытоугольная глаукомаслезная жидкость[Рукина Д.А. Значение матриксной металлопротеиназы в патогенезе первичной открытоугольной глаукомы / Д.А. Рукина, А.В. Кириенко // Оригинальные исследования. - 2011. -№ 3. - С. 41-43.][A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia / Z. Gu [et al.] // J Neurosci. - 2005. - Vol. 25. -P. 6401-6408.][Differential expression of matrix metalloproteinases in monkey eyes with experimental glaucoma or optic nerve transection / О.А. Agapova [et al.] // Brain Res. - 2003. - Vol. 967, №1-2. - P. 132-143.][Differential in matrix metalloproteinases gelatinase B (MMP-9) protect retinal ganglion cell death a nerve ligation / S.K. Chintala [et al] // J. Biol. Chem. - 2002. -Vol. 277. - P. 47461-47468.][Elastosis of the lamina cribrosa in glaucomatous optic neuropathy / J.D. Pena [et al.] // Exp Eye Res. - 1998. - Vol. 67. -P. 517-524.][Expression of matrix metalloproteinases end inhibitor by human trabecular meshwork / J.P. Alexander [et al.] // Invest Ophthamol Vis sci. - 1991. - Vol. 32. - P. 172-180.][Manabe S. Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death / S. Manabe, Z. Gu, S.A. Lipton // Invest. Ophthalmol. Vis. Sci. - 2005. - Vol. 46. - P. 4747-4753.][Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head / X.Yan [et al] // Arch Ophthalmol. -2000. - Vol. 118. - P. 666-673.][Matrix metalloprote inases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome/glaucoma and primary open-angle glaucoma / U. Schlötzer-Schrehardt [et al.] // Invest Ophthalmol Vis Sci. - 2003. - Vol. 44, №3. - P. 1117-11125.][Retinal ganglion cell apoptosis in glaucoma is related to intraocular presure and IOP-induced effects on extraccellular matrix / L.Guo [et al.] // Invest. Ophthalmol. Sci. - 2005. - Vol. 46. - P. 175-182.][Ronkoo S. Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patient with primary open-angle glaucoma and exfoliation glaucoma / S. Ronkoo, P. Rekonen, K. Kaarnirata // Greafe’s Arch. Clin. Exp. Ophtalmology. - 2007. - Vol. 245. - P. 697-700.][Schachatchabel U. The mechanism of action of prostaglandins on uveoscleral outflow / U. Schachatchabel, J. Lindsey, R. Weinberg // Curr. Opin. Ophthlmol. - 2000. - Vol. 11, № 2. - P. 112-115.][The influence of cerebrospinal fluid pressure upon the lamina cribrosa tissue pressure gradient / W.H. Morgan [et al.] // Investigative Ophthalmology and Visual Science. - 1995. - Vol. 36. - P. 1163-1172.]