I.P. Pavlov Russian Medical Biological HeraldI.P. Pavlov Russian Medical Biological HeraldРоссийский медико-биологический вестник имени академика И.П. Павлова0204-34752500-2546Eco-Vector464210.17816/PAVLOVJ20153120-125ArticlesСтатьиResearch ArticleAN ANALYSIS OF PROBABLE MECHANISMS OF ANTIDEPRESSANT ACTIVITY OF NEURONAL N-METHYL-D-ASPARTATE RECEPTOR BLOCKERSАнализ вероятных механизмов антидепрессивной активности блокаторов нейрональных N-метил-Э-аспартатных рецепторов15092015233NO3 (2015)№3 (2015)12012528102016Copyright ©; 2015, Abramets I.I., Evdokimov D.V.Copyright ©; 2015, Абрамец И.И., Евдокимов Д.В.2015Abramets I.I., Evdokimov D.V.Абрамец И.И., Евдокимов Д.В.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/pavlovj/article/view/4642

Slow appearance of therapeutic action and partial therapeutic efficiency of used today antidepressants demand otherwise approaches for creation on principle new antidepressants. One from prototypes such drugs is ketamine possessing by capacity fast to suppress the symptoms of refractory depression. However a nature of antidepressant activity did not ascertained decisively. The most popular hypotheses of antidepressant action of ketamine and other N-methyl-D-aspartate receptors blockers were analyzed in this review.

Медленное развитие терапевтического действия и неполная терапевтическая эффективность традиционных антидепрессантов диктуют потребность в разработке иных подходов к созданию принципиально новых антидепрессантов. Одним из их прообразов является кетамин, у которого ранее была выявлена быстро развивающаяся антидепрессивная активность. Однако природа этой активности окончательно не выяснена. В данном обзоре проанализированы наиболее популярные гипотезы антидепрессивного действия кетамина и других антагонистов N-метил-D-аспартатных рецепторов.

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