I.P. Pavlov Russian Medical Biological HeraldI.P. Pavlov Russian Medical Biological HeraldРоссийский медико-биологический вестник имени академика И.П. Павлова0204-34752500-2546Eco-Vector465410.17816/PAVLOVJ2014368-74ArticlesСтатьиResearch ArticleBIOLOGY OF HUMAN DENDRITIC CELLS AND THEIR ROLE IN INFECTIOUS DISEASESБИОЛОГИЯ ДЕНДРИТНЫХ КЛЕТОК ЧЕЛОВЕКА И ИХ РОЛЬ В ИНФЕКЦИОННОЙ ПАТОЛОГИИ15092014223NO3 (2014)№3 (2014)687428102016Copyright ©; 2014, Tsvetkov V.V., Sologub T.V., Tokin I.I.Copyright ©; 2014, Цветков В.В., Сологуб Т.В., Токин И.И.2014Tsvetkov V.V., Sologub T.V., Tokin I.I.Цветков В.В., Сологуб Т.В., Токин И.И.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/pavlovj/article/view/4654

Dendritic cells are a heterogeneous human population of professional antigen-presenting cells. They are known to play a critical role in the regulation of both innate and acquired immune response. The functional activity of dendritic cells depends on the action signals microenvironment. Of particular interest is the study of the role of dendritic cells in the pathogenesis of various infectious diseases in humans.

Дендритные клетки человека представляют собой гетерогенную популяцию профессиональных антигенпрезентирующих клеток. Известно, что они играют важнейшую роль в регуляции как врожденного, так и приобретенного иммунного ответа. Функциональная активность той или иной субпопуляции дендритных клеток напрямую зависит от того, в каких условиях и под действием каких сигналов микроокружения происходило развитие этой субпопуляции, ее дифференцировка и созревание. Особый интерес представляет собой изучение роли дендритных клеток в патогенезе различных инфекционных заболеваний человека.

dendritic cellsantigen presenting cellsimmunitypathogen-associated molecular patternsдендритные клеткиантигенпрезентирующие клеткииммунитетпатоген-ассоциированные молекулярные паттерныA CD1a+/CD11c+subset of human blood dendritic cells is a direct precursor of Langerhans cells / T. Ito [et al.] // J. Immunol. -1999. - Vol. 163. - P. 1409-1419.Characterization of expression, cytokine regulation, and effector function of the high affinity IgG receptor Fcyc1 (CD64) expressed on human blood dendritic cells / N.A. Fanger [et al.] // J. Immunol. -1997. - Vol. 158. - P. 3090-3098.Cloning and characterization of a specific receptor for the novel CC chemoline MIP-3 alpha from lung dendritic cells / C.A. Power [et al.] // J. Exp. Med. -1997. - Vol. 186. - P. 825-835.Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products / F. Sallusto [etal.] // J. Exp. Med. - 1995. - Vol. 182. - P. 389-400.Expression of C-type lectin receptors by subsets of dendritic cells in human skin / S. Ebner [et al.] // Int. Immunol. - 2004. - Vol. 16. - P. 877-887.GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells / C. Caux [et al.] // Nature. - 1992. - Vol. 360. - P. 258.Hart D.N. Dendritic cells: unique leukocyte populations which control the primary im mune response / D.N. Hart // Blood. -1997. - Vol. 90. - P. 3245-3287.Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature / U. O’Doherty [et al.] // J. Immunol. - 1994. - Vol. 82. - P. 487-493.In vivo generation of human dendritic cell subsets by Flt3 ligand / E. Maraskovsky [et al.] // Blood. - 2000. - Vol. 96. - P. 878-884.Katsuaki S. Dendritic Cells-Nature and Classification / S. Katsuaki, F. Shigeharu // Allergology International. - 2007. -Vol. 56. - P. 183-191.Katz S.I. Epidermal Langerhans cells are derived from cells originating in bone marrow / S.I. Katz, K. Tamaki, D.H. Sachs // Nature. - 1979. - Vol. 282. -P. 324-326.Langerhans P. Ueber die Nerven der menschlichen Haut / P. Langerhans // Archiv fur pathologische Anatomie und Physiologie, und fur Klinische Medicin. - Berlin, 1868. - Bd. 44. - S. 325-337.Large-scale culture and selective maturation of human Langerhans cells from granulocyte colony-stimulating factor-mobilized CD34 progenitors / E.M. Gatti [et al.] // J. Immunol. - 2000. - Vol. 164. - P. 3600-3607.Liu Y.J. Dendritic Cell Subsets and Llineages, and their functions in innate and adaptive immunity / Y.J. Liu // Cell. - 2001. - Vol. 106. - P. 259-262.Matsuda J.L. Presentation of self and microbial lipids by CD1 molecules / J.L. Matsuda, Kronenberg // Curr. Opin. Immunol. - 2001. - № 13. - P. 19-25.Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines / S. Sozzani [et al.] // J. Immunol. - 1997. - Vol. 159. - P. 1993-2000.Sallusto F. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor / F. Sallusto, A. Lanzavecchia // J. Exp. Med. - 1994. - Vol. 179. - P. 1109-1118.Separate pathways for antigen presentation by CD1 molecules / M. Sugita [et al.] // Immunity. - 1999. - Vol. 11. -P. 743-752.Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells / D. Jarrossay [et al.] // Eur. J. Immunol. - 2001. - Vol. 31. -P. 3388-3398.Steinman R.M. Identification of a novel cell type in peripheral lymphoid organs of mice / R.M. Steinman, Z.A. Cohn // J. Exp. Med. - 1973. - Vol. 137. -P. 1142-1162.The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compart ments of dendritic cells is regulated by inflammatory stimuli / K. Inaba [et al.] // J. Exp. Med. - 2000. - Vol. 191.The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families / S.H. Park [et al.] // J. Exp. Med. - 2001. - Vol. 193. -P. 893-904.Thomas R. Human peripheral blood dendritic cell subset. Isolation and characterisation of precursor and mature antigen-presenting cells / R. Thomas, P.E. Lipsky // J. Immunol. - 1994. - Vol. 153. -P. 4016-4028.Trombetta E.S. Cell biology of antigen processing in vitro and in vivo / E.S. Trombetta, I. Mellman // Annu. Rev. Immunol. - 2005. - Vol. 23. -P. 975-1028.