I.P. Pavlov Russian Medical Biological HeraldI.P. Pavlov Russian Medical Biological HeraldРоссийский медико-биологический вестник имени академика И.П. Павлова0204-34752500-2546Eco-Vector465510.17816/PAVLOVJ2014375-86ArticlesСтатьиResearch ArticleEPSTEIN-BARR VIRUS ROLE IN ONCOGENESISРОЛЬ ВИРУСА ЭПШТЕЙНА-БАРР В ОНКОГЕНЕЗЕ15092014223NO3 (2014)№3 (2014)758628102016Copyright ©; 2014, Shestakova I.V., Yushyuk N.D.Copyright ©; 2014, Шестакова И.В., Ющук Н.Д.2014Shestakova I.V., Yushyuk N.D.Шестакова И.В., Ющук Н.Д.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/pavlovj/article/view/4655

We now recognize that the Epstein-Barr virus (EBV) plays a pivotal role in the development of some lymphomas and lymphoproliferative disorders that include B-cell, T-cell and NK-cell processes, and epithelial and mesenchymal tumors. While over recent years, EBV associated lymphomas are becoming increasingly recognized in patients without overt immunodeficiency. Improved understanding of the biology of these lymphomas and the role that EBV plays in their pathogenesis has paved the way for improved therapies targeted at critical signaling pathways as well as the development of novel cellular therapies. This review discusses the unique cytomorphology, clinical and immunophenotype signs and ancillary studies required to diagnose EBV-related neoplasms.

В настоящее время признана ключевая роль вируса Эпштейна-Барр (ВЭБ) в развитии некоторых лимфом и лимфопролиферативных заболеваний (B- и T- и NK-клеточные процессы, эпителиальные и мезенхимальные злокачественные опухоли). В последние годы вызываемые ВЭБ лимфомы все чаще стали диагностироваться у пациентов без выраженного иммунодефицита. Углубление знания биологии этих лимфом и выяснение роли ВЭБ в их патогенезе приведет к улучшению терапии и развитию новых клеточных видов терапии. В данном обзоре обсуждаются характерные клинические, цитоморфологические и иммунофенотипические признаки и вспомогательные исследования, необходимые для диагностики новообразований, вызванных ВЭБ.

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