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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">I.P. Pavlov Russian Medical Biological Herald</journal-id><journal-title-group><journal-title xml:lang="en">I.P. Pavlov Russian Medical Biological Herald</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский медико-биологический вестник имени академика И.П. Павлова</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0204-3475</issn><issn publication-format="electronic">2500-2546</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">4673</article-id><article-id pub-id-type="doi">10.17816/PAVLOVJ2012414-19</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">CHARACTERISTICS AND TRENDS OF PRIMARY DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS IN RYAZAN REGION</article-title><trans-title-group xml:lang="ru"><trans-title>ХАРАКТЕРИСТИКА И ТРЕНДЫ ПЕРВИЧНОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ МБТ В РЯЗАНСКОЙ ОБЛАСТИ</trans-title></trans-title-group></title-group><pub-date date-type="pub" iso-8601-date="2012-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2012</year></pub-date><volume>20</volume><issue>4</issue><issue-title xml:lang="en">NO4 (2012)</issue-title><issue-title xml:lang="ru">№4 (2012)</issue-title><fpage>14</fpage><lpage>19</lpage><history><date date-type="received" iso-8601-date="2016-10-28"><day>28</day><month>10</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, Panin I.V., Dobin V.L., Oskin D.N.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, Панин И.В., Добин В.Л., Оськин Д.Н.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">Panin I.V., Dobin V.L., Oskin D.N.</copyright-holder><copyright-holder xml:lang="ru">Панин И.В., Добин В.Л., Оськин Д.Н.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/pavlovj/article/view/4673">https://journals.eco-vector.com/pavlovj/article/view/4673</self-uri><abstract xml:lang="en"><p>The article is devoted to drug-resistant tuberculosis in the Ryazan region. There is a tendency to the increase of the amount of tubercular patients among women of middle ages. It is stated that in the period from 1999 to 2007 mycobacteria’s structure of drug-resistance has not changed considerably. The exception was a dramatic increase of cases with simultaneous drug-resistance to the four first-line antibiotics. The direct interdependence between the character of drug-resistance and the speed and intensity of tuberculosis microorganisms growth has not been found yet.</p></abstract><trans-abstract xml:lang="ru"><p>Данная статья посвящена эпидемиологии лекарственно-устойчивого туберкулеза в Рязанском регионе. Была отмечена тенденция к увеличению количества больных туберкулезом женщин среднего возраста. Установлено, что за период 19992007 годов структура лекарственной резистентности микобактерий существенно не изменилась. Исключением послужило резкое увеличение числа случаев одновременной ЛУ к четырем АБП первого ряда. Достоверного влияния характера лекарственной резистентности на скорость и интенсивность роста культур МБТ выявлено не было.</p></trans-abstract><kwd-group xml:lang="en"><kwd>tuberculosis</kwd><kwd>epidemiology</kwd><kwd>Ryazan region</kwd><kwd>drug resistance</kwd><kwd>Mycobacterium tuberculosis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>туберкулез</kwd><kwd>эпидемиология</kwd><kwd>рязанский регион</kwd><kwd>лекарственная резистентность</kwd><kwd>микобактерии туберкулеза</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Данилова Е.В. 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