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Interrelation between the system markers of hemostasis and hemocoagulation disorders in patients with tuberculosis in respira-tory organs and comorbid diabetes mellitus after surgical interven-tion on respiratory organs
- Authors: Chitorelidze G.V.1, Serebryanaya B.A.1, Lepekha L.N.1, Papkov A.V.2, Bagirov M.A.1
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Affiliations:
- Central Research Institute of Tuberculosis
- Ryazan State Medical University
- Issue: Vol 28, No 4 (2020)
- Pages: 437-448
- Section: Original study
- URL: https://journals.eco-vector.com/pavlovj/article/view/44754
- DOI: https://doi.org/10.23888/PAVLOVJ2020284437-448
- ID: 44754
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Abstract
The relevance of the work is determined by the necessity to study the markers of the coagulation system of blood and hemocoagulation disorders in patients with pulmonary tuberculosis and comorbid diabetes mellitus in different stages of the postoperative period.
Aim. This study was conducted to identify the interrelation between the system markers of hemostasis and the signs of intravascular blood coagulation development in patients with pulmonary tuberculosis and comorbid diabetes mellitus (TB-DM) in terms of the volume of surgical intervention on respiratory organs.
Materials and Methods. The extent of changes in the system markers of hemostasis was determined in 89 patients with TB-DM before and after surgical treatment. The following parameters of the blood coagulation system were measured: concentration of fibrinogen, level of soluble fibrin–monomer complexes, compensatory potential of fibrinolysis level, activities of the fibrinolytic and anticoagulation systems (antithrombin III). The parameters of prothrombin activity were also studied. The operation material of the lungs was prepared for morphological examination.
Results. The parameters of the hypercoagulation syndrome increased in all the study groups from days 3 to 5 and reached the maximum on days 7 to 10 and 14 to 17 of the postoperative period. The compensatory activation of the fibrin-stabilizing factor and the fibrinolytic system was also observed. The most prominent changes in the hemostasis markers were found in the group of patients after lobectomy. Microthrombotic lesions of the vessels of pulmonary microcirculation with a partial or complete obturation of the lumen were morphologically visualized.
Conclusion. Hypercoagulation syndrome with intravascular blood coagulation was observed in this category of patients. This finding indicated that thromboembolic complications require timely prevention and treatment. This study may be used as a basis for developing measures that can prevent hemocoagulation complications in patients with TB-DM after surgical treatments.
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About the authors
Georgy V. Chitorelidze
Central Research Institute of Tuberculosis
Author for correspondence.
Email: chitorelidze2015@yandex.ru
ORCID iD: 0000-0001-5062-9788
SPIN-code: 4301-7364
PhD-Student of the Surgery Department
Russian Federation, MoscowBella A. Serebryanaya
Central Research Institute of Tuberculosis
Email: b.serebryanaya@yandex.ru
ORCID iD: 0000-0001-9168-0336
SPIN-code: 4918-4812
PhD in Biological Sciences, Leading Researcher of the Pathomorphology, Cell Biology and Biochemistry Department
Russian Federation, MoscowLarisa N. Lepekha
Central Research Institute of Tuberculosis
Email: lep3@yandex.ru
ORCID iD: 0000-0002-6894-2411
SPIN-code: 6228-8382
ResearcherId: B-1165-2019
MD, PhD, Professor of the Pathomorphology, Cell Biology and Biochemistry Department
Russian Federation, MoscowAleksandr V. Papkov
Ryazan State Medical University
Email: avpapkov@mail.ru
ORCID iD: 0000-0003-2988-990X
SPIN-code: 4902-5864
ResearcherId: L-4679-2018
MD, PhD, Professor of the Department of Phthisiology with a Course of Radiation Diagnosis
Russian Federation, 9, Vysokovoltnaja, Ryazan, 390026Mamad-Bagir A. Bagirov
Central Research Institute of Tuberculosis
Email: bagirov60@gmail.com
ORCID iD: 0000-0001-9788-1024
SPIN-code: 8820-5448
MD, PhD, Professor of the Department of Surgery
Russian Federation, MoscowReferences
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