Pediatrician (St. Petersburg)Pediatrician (St. Petersburg)2079-78502587-6252Eco-Vector101610.17816/PED6348-51Research ArticleQuality of life after Whipple pancreatoduodenectomy and pylorus-preserving pancreatoduodenectomy: a comparative studyKokhanenkoNikolay Yurevich<p>MD, PhD, Dr Med Sci, Professor, Head of the Prof. A. A. Rusanov Department of Faculty Surgery</p>kohanenko@list.ruPaveletsKonstantin Vadimovich<p>MD, PhD, Dr Med Sci, Associate Professor, Chief of Surgery</p>9972497@list.ruRadionovYuri Vasilevich<p>surgeon</p>Radionov8604@gmail.comShiryajevYurii Nikolaevich<p>Associate Professor, Prof. A. A. Rusanov Department of Faculty Surgery</p>shiryajev@yandex.ruBorisovaNatalya Yurevna<p>Assistant, Prof. A. A. Rusanov Department of Faculty Surgery</p>natzur@mail.ruSt. Petersburg State Pediatric Medical UniversitySt. Petersburg State City Mariinskaja HospitalSt. Petersburg State Pokrovskaja Hospital1509201563485105022016Copyright © 2015, Kokhanenko N.Y., Pavelets K.V., Radionov Y.V., Shiryajev Y.N., Borisova N.Y.2015<p>The authors performed a comparative analysis of the Quality of life (QOL) in 97 patients after pancreatoduodenectomy, 55 of whom underwent pylorus-preserving surgery (PPDE), and 42 underwent classic Whipple procedure (GPDE). QOL was evaluated using questionnaire EORTC-QLQ-C30, version 3.0, and both analyzed groups were divided into 3 subgroups according to the time period after the surgery (less than 6 mo, 6-12 mo, and more than 12 mo). All the patients were operated on for pancreatic or periampullary cancer. During the first period after surgery (less than 6 mo), the integral QOL index is lower than in patients who were examined after the first 6 mo. After PPDE, parameters of physical, role, emotional, cognitive, and social functioning were higher than after GPDE; however, these differences were not statistically significant (p 0,05). Indicators of QOL have changed with time, but intergroup (PPDE vs GPDE) differences were not statistically significant in every analyzed time period after surgery. Financial constrains were registered in patients of both groups and at different times after surgical treatment.</p>pancreatic cancerperiampullary cancerwhipple pancreatoduodenectomypylorus-preserving pancreatoduodenectomyquality of lifeрак поджелудочной железыпериампулярный ракгастропанкреатодуоденальная резекцияпилоруссохраняющая панкреатодуоденальная резекциякачество жизни[Дронов А.И., Крючина Е. А., Добуш Р.Д. Комплексное лечение рака поджелудочной железы. Украинский журнал хирургии. 2011; 4: 20-24.][Chakravarty K, Hsu J, Liu K, et al. Prognosis and feasibility of en-bloc vascular resection in stage II pancreatic adenocarcinoma. World J Gastroenterol. 2010; 16 (8): 997-1002.][Choi SH, Kang CM, Kim DH, et al. Robotic pylorus preserving pancreaticoduodenectomy with mini-laparotomy reconstruction in patient with ampullary adenoma. J Korean Surg Soc, 2011; 81: 355-359.][Gehrig T, Knebel P, Scheel V, et al. LigaSure Impact™ versus conventional dissection technique in pylorus-preserving pancreatoduodenectomy in clinical suspicion of cancerous tumours on the head of the pancreas: study protocol for a randomised controlled trial. Trials, 2011; 12: 162.][Hackert T, Bruckner T, Dorr-Harim C, et al. Pylorus resection or pylorus preservation in partial pancreatico-duodenectomy (PROPP study): study protocol for a randomized controlled trial. Trials, 2013; 14: 44.][Kawai M, Tani M, Hirono S, et al. Pylorus Ring Resection Reduces Delayed Gastric Emptying in Patients Undergoing Pancreatoduodenectomy. Annals of Surgery, 2011; 253 (3): 495-501.][Malleo G, Crippa S, Butturini G, et al. Delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy: validation of International Study Group of Pancreatic Surgery classification and analysis of risk factors. International Hepato-Pancreato-Biliary Association HPB, 2010; 12: 610-618.][Masui T, Doi R, Kawaguchi Y. et al. Delayed gastric emptying improved by straight stomach reconstruction with twisted anastomosis to the jejunum after pylorus-preserving pancreaticoduodenectomy (PPPD) in 118 consecutive patients at a single institution. Surg Today. 2012; 42: 441-446.]