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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatrician (St. Petersburg)</journal-id><journal-title-group><journal-title xml:lang="en">Pediatrician (St. Petersburg)</journal-title><trans-title-group xml:lang="ru"><trans-title>Педиатр</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2079-7850</issn><issn publication-format="electronic">2587-6252</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">10410</article-id><article-id pub-id-type="doi">10.17816/PED94105-112</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Visualization capabilities of experimental oncological models in small laboratory animals</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности визуализации при воспроизведении экспериментальных онкологических моделей у мелких лабораторных животных</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pechatnikova</surname><given-names>Valeria A.</given-names></name><name xml:lang="ru"><surname>Печатникова</surname><given-names>Валерия Антоновна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Researcher, Trials Center of Radiopharmaceutical</p></bio><bio xml:lang="ru"><p>научный сотрудник, Испытательный центр радиофармпрепаратов</p></bio><email>floluttrell@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Trashkov</surname><given-names>Alexander P.</given-names></name><name xml:lang="ru"><surname>Трашков</surname><given-names>Александр Петрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Head, Trials Center of Radiopharmaceutical</p></bio><bio xml:lang="ru"><p>канд. мед. наук, заведующий, Испытательный центр радиофармпрепаратов</p></bio><email>alexandr.trashkov@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zelenenko</surname><given-names>Maria A.</given-names></name><name xml:lang="ru"><surname>Зелененко</surname><given-names>Мария Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Researcher, Experimental Pharmacology Department</p></bio><bio xml:lang="ru"><p>научный сотрудник, отдел экспериментальной фармакологии</p></bio><email>magu56110@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Verlov</surname><given-names>Nikolay A.</given-names></name><name xml:lang="ru"><surname>Верлов</surname><given-names>Николай Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Senior researcher, Trials Center of Radiopharmaceutical</p></bio><bio xml:lang="ru"><p>канд. биол. наук, старший научный сотрудник, Испытательный центр радиофармпрепаратов</p></bio><email>virlov@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chizh</surname><given-names>Grigorii A.</given-names></name><name xml:lang="ru"><surname>Чиж</surname><given-names>Григорий Алексеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Junior Researcher, Molecular and Radiation Biophysics Division</p></bio><bio xml:lang="ru"><p>младший научный сотрудник, отделение молекулярной и радиационной биофизики</p></bio><email>ya.grisha234@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khotin</surname><given-names>Michael G.</given-names></name><name xml:lang="ru"><surname>Хотин</surname><given-names>Михаил Георгиевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Associate Professor, Head, Cell Technology Center</p></bio><bio xml:lang="ru"><p>канд. биол. наук, доцент, заведующий, Центр клеточных технологий</p></bio><email>h_mg@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vasiliev</surname><given-names>Andrei G.</given-names></name><name xml:lang="ru"><surname>Васильев</surname><given-names>Андрей Глебович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Dr. Med. Sci., Head, Pathophysiology Department</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор, зав. кафедрой патологической физиологии с курсом иммунопатологии</p></bio><email>avas7@mail.ru</email><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre “Kurchatov Institute”</institution></aff><aff><institution xml:lang="ru">ФГБУ «Петербургский институт ядерной физики им. Б.П. Константинова Национального исследовательского центра „Курчатовский институт“»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Sechenov Institute of Ephysiology and Biochemistry, Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru">ФГБУН «Институт эволюционной физиологии и биохимии им. И.М. Сеченова» РАН</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Institute of Cytology RAS</institution></aff><aff><institution xml:lang="ru">Институт цитологии Российской академии наук</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">St. Petersburg State Pediatric Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-10-30" publication-format="electronic"><day>30</day><month>10</month><year>2018</year></pub-date><volume>9</volume><issue>4</issue><issue-title xml:lang="en">VOL 9, NO4 (2018)</issue-title><issue-title xml:lang="ru">ТОМ 9, №4 (2018)</issue-title><fpage>105</fpage><lpage>112</lpage><history><date date-type="received" iso-8601-date="2018-10-30"><day>30</day><month>10</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Pechatnikova V.A., Trashkov A.P., Zelenenko M.A., Verlov N.A., Chizh G.A., Khotin M.G., Vasiliev A.G.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Печатникова В.А., Трашков А.П., Зелененко М.А., Верлов Н.А., Чиж Г.А., Хотин М.Г., Васильев А.Г.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Pechatnikova V.A., Trashkov A.P., Zelenenko M.A., Verlov N.A., Chizh G.A., Khotin M.G., Vasiliev A.G.</copyright-holder><copyright-holder xml:lang="ru">Печатникова В.А., Трашков А.П., Зелененко М.А., Верлов Н.А., Чиж Г.А., Хотин М.Г., Васильев А.Г.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/pediatr/article/view/10410">https://journals.eco-vector.com/pediatr/article/view/10410</self-uri><abstract xml:lang="en"><p>For a long time non-invasive imaging methods have been inaccessible in preclinical practice; their introduction lately has broadened the boundaries of relevant studies and felicitated new approaches to solving fundamental problems. Up-to-date imaging methods constitute an essential component of preclinical and translational biomedical research allowing quick and non-invasive extended representation of structural organization and functional characteristics of pathological processes in vivo. Methods of radiation diagnosis and nuclear magnetic resonance allow to assess the state of bones, soft tissues, internal organs, blood vessels and peripheral nerve fibers in various animals, not only mammals, but also fish, amphibians, reptiles and insects. Multiparametric studies can uniquely localize any anatomical structure or pathological process. However, not all existing techniques are applicable to various oncological models of small laboratory animals.</p></abstract><trans-abstract xml:lang="ru"><p>До последнего времени неинвазивные методы визуализации были недоступны в доклинических исследованиях, и с их появлением установленные границы расширились и стало возможным найти новые подходы к решению фундаментальных задач в соответствии с запросами клинической практики. Современные методы визуализации представляют собой важнейший компонент доклинических и трансляционных биомедицинских исследований и позволяют быстро и не выводя животное из эксперимента расширить представление о структурной организации, функциональных характеристиках и распространенности патологического процесса in vivo. С помощью методов лучевой диагностики и ядерного магнитного резонанса можно оценить состояние костей скелета, мягких тканей, внутренних органов, кровеносных сосудов и периферических нервных волокон у различных животных, включая рыб, земноводных, рептилий, млекопитающих и насекомых. Мультипараметрические исследования позволяют однозначно локализовать любую анатомическую структуру или патологический процесс.</p></trans-abstract><kwd-group xml:lang="en"><kwd>preclinical imaging</kwd><kwd>magnetic resonance imaging</kwd><kwd>oncology</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>доклиническая визуализация</kwd><kwd>магнитно-резонансная томография</kwd><kwd>онкология</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Хайцев Н.В., Васильев А.Г., Трашков А.П., и др. 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