Pediatrician (St. Petersburg)Pediatrician (St. Petersburg)Педиатр2079-78502587-6252Eco-Vector10630410.17816/PED12615-26Original studiesОригинальные статьиResearch ArticleQuantitative assessment of regional pulmonary perfusion using three-dimensional ultrafast dynamic contrast-enhanced magnetic resonance imaging: pilot study results in 10 patientsВозможности количественной оценки регионарной легочной перфузии с использованием трехмерной сверхбыстрой динамической контрастной магнитно-резонансной томографии: предварительный опыт у 10 испытуемыхZakharovaAnna V.ЗахароваАнна Валерьевна
Russian Federation

Assistant Professor of the Department of Medical Biophysics; Radiologist

ассистент кафедры медицинской биофизики, врач-рентгенолог отдела лучевой диагностики

ellin-ave@yandex.ruPritsVictoria V.ПрицВиктория Владимировна
Russian Federation

Medical Physicist

медицинский физик отделения лучевой диагностики

brockendex.666@gmail.comPozdnyakovAlexander V.ПоздняковАлександр Владимирович
Russian Federation

MD, PhD, Dr. Med. Sci., Professor, Head of the Department of Radiology Diagnostic

д-р мед. наук, профессор, заведующий отделением лучевой диагностики

pozdnyakovalex@yandex.ruSt. Petersburg State Pediatric Medical UniversityСанкт-Петербургский государственный педиатрический медицинский университетCity Multidisciplinary Hospital No. 2Городская многопрофильная больница № 2City Mariinsky Hospital, Saint PetersburgГородская Мариинская больница, Санкт-ПетербургAcademician A.M. Granov Russian Scientific Center for Radiology and Surgical TechnologiesРоссийский научный центр радиологии и хирургических технологий им. акад. А.М. ГрановаSt. Petersburg State Pediatric Medical UniversityСанкт-Петербургский государственный педиатрический медицинский университет1804202212615261504202215042022Copyright ©; 2022, Zakharova A.V., Prits V.V., Pozdnyakov A.V.Copyright ©; 2022, Захарова А.В., Приц В.В., Поздняков А.В.Copyright ©; 2022, Zakharova A., Prits V., Pozdnyakov A.2022Zakharova A.V., Prits V.V., Pozdnyakov A.V.Захарова А.В., Приц В.В., Поздняков А.В.Zakharova A., Prits V., Pozdnyakov A.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/pediatr/article/view/106304

Background. Currently there is a high demand in reliable noninvasive diagnostic technique assessing the physiological parameters of the lungs. We are exploring the three-dimensional ultrafast MRI sequence as a novel diagnostic modality allowing the assessment of regional quantitative perfusion parameters in pulmonary tissue.

Aim. To assess regional differences in quantitative pulmonary perfusion parameters in 10 volunteers with no evidence of interstitial lung disease by computed tomography, clinical, and laboratory data.

Materials and methods. 10 volunteers with no signs of interstitial lung disease were examined by three-dimensional ultrafast dynamic contrast-enhanced MR imaging using 3D T1-weighted images. The values of pulmonary blood flow (PBF), mean transit time (MTT), and pulmonary blood volume (PBV) for the targeted regions of interest were calculated based on the dynamic image series. For calculations, arterial input function (AIF) was used, as well as the time-intensity curves.

Results. The values of PBF, MTT, and PBV showed statistically significant differences between central and peripheral sections of lungs. Provided model can be implemented for quantitative assessment of regional pulmonary perfusion allows it to be used to determine the reliability of PBF, MTT and PBV values.

Conclusions. Three-dimensional ultrafast MRI sequence is a novel diagnostic modality allowing the assessment of regional quantitative pulmonary perfusion parameters in pulmonary tissue, regardless of physiological features of blood supply mechanisms in different lung regions.

Актуальность. В настоящее время ведется изучение новых и адаптация уже существующих методов лучевой диагностики для оценки физиологических параметров легких. Необходимы дальнейшие исследования методики трехмерной сверхбыстрой магнитно-резонансной томографии легких в качестве нового диагностического метода, позволяющего оценивать региональные количественные параметры перфузии в легочной ткани.

Цель исследования — оценить региональные различия в количественных параметрах легочной перфузии у 10 добровольцев, не имеющих признаков интерстициального поражения легких по данным компьютерной томографии, а также клинико-лабораторным данным.

Материалы и методы. Проведено обследование 10 добровольцев без признаков интерстициального поражения легких с применением трехмерной сверхбыстрой динамической контрастной магнитно-резонансной томографии на базе градиентных 3D-Т1-взвешенных изображений. На основе динамических серий изображений получены значения PBF (скорость кровотока), PBV (объем кровотока) и MTT (среднее время пассажа) для выбранных областей интереса. Для вычислений использовали входную артериальную функцию AIF, а также кривые зависимости интенсивности от времени.

Результаты. Значения PBF, MTT и PBV показали достоверные различия между центральными и периферическими отделами легочных долей. Математическая модель, использованная при количественной оценке регионарной легочной перфузии, позволяет использовать ее для определения достоверности значений PBF, MTT и PBV.

Заключение. Трехмерная сверхбыстрая магнитно-резонансная последовательность позволяет количественно оценивать перфузионные параметры для легочной ткани вне зависимости от физиологических особенностей механизмов кровоснабжения различных зон легких.

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