Pediatrician (St. Petersburg)Pediatrician (St. Petersburg)2079-78502587-6252Eco-Vector116510.17816/PED5460-64Research ArticleOutcomes of treatment of juvenile idiopathic arthritis related uveitis with TNF-alpha inhibitorsGaidarEkaterina VladimirovnaMD, Research Fellow, Chair of Hospital Pediatricsgaidare85@gmail.comKostikMikhail MikhaylovichMD, PhD, Associate Professor, Chair of Hospital Pediatricsmikhail.kostik@gmail.comSnegirevaLudmila StepanovnaMD, Department of Pediatrics N 3l.s.snegireva@mail.ruDubkoMargarita FedorovnaMD, PhD, Associate Professor, Chair of Hospital Pediatricsandrq@rambler.ruMasalovaVera VasilyevnaMD, Research Fellow, Chair of Hospital Pediatricsmasalova.vera@gmail.comSerogodskayaElena DmitrievnaMD, PhD, Associate Professor, Chair of Ophthalmologyedserogod@yandex.ruMacijevskaAida Sirradzidinovnaophthalmologistaidajed@inbox.lvHynesAllaophthalmologistrozalat@hotmail.comSaint Petersburg State Pediatric Medical UniversityDr. Solomatina EYE Surgery CenterEye Care Physicians and Surgeons1512201454606408022016Copyright © 2014, Gaidar E.V., Kostik M.M., Snegireva L.S., Dubko M.F., Masalova V.V., Serogodskaya E.D., Macijevska A.S., Hynes A.2014The aim of the study was to evaluate the efficacy of two anti-TNF-alpha biological agents: Adalimumab (humanized monoclonal anti-TNF-alpha antibody) and Infliximab (chimeric monoclonal antibody that binds both circulating and membrane-bound TNF-alpha receptors) in treatment of Juvenile Idiopathic Arthritis related uveitis. 37 children (73 % girls) with uveitis associated with aggressive forms of JIA who failed Methotrexate and topical treatment; Methotrexate and other immunosuppressive agents and systemic corticosteroids were included in the study. The age of patients at the beginning of biological therapies ranged 5-17 years. In ADA group the remission was observed in 61 % of cases, in 18 % we saw the reduction of flare-ups and in 14 % of children we registered exacerbation of the disease which was caused in most cases by discontinuation of non-biological drug. In INF group we observed remission in 78 % of the cases, no improvement in 22 %. The speed of remission in JIA associated uveitis treated with ADA and INF depended on the severity of uveitis, the time between the beginning of the disease and administration of immunosuppressive therapy. Early administration of anti-TNF-alpha agents, when there is no results from standard immunosuppressive therapy, allowed us to achieve remission in a shorter period of time and also allowed as to decrease the severity of complications of uveitis, as well as reduce the side effects of immunosuppressive therapy, especially of corticosteroids. 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