Pediatrician (St. Petersburg)Pediatrician (St. Petersburg)2079-78502587-6252Eco-Vector1567610.17816/PED10317-24Research ArticleVitamin D and neurospecific proteins in children with inflammatory demyelinating diseases of central nervous systemBukhalkoMarina A.<p>Postgraduate Student, Department of Neuroinfections and Organic Pathology of the Nervous System</p>marinabuhalko@mail.ruSkripchenkoElena Yu.<p>MD, PhD, Dr Med Sci, Senior Researcher, Department of Neuroinfections and Organic Pathology of the Nervous System; PhD, Associate Professor of the Department of Neuropsychiatry FP and DPO</p>wwave@yandex.ruAlekseevaLidiya A.<p>PhD, Leading Scientist, Department of Clinical Laboratory Diagnostics</p>kldidi@mail.ruSkripchenkoNataliya V.<p>MD, PhD, Dr Med Sci, Deputy Director, Department of Clinical Laboratory Diagnostics; Head of the Department of Infectious Diseases in Children FP and DPO</p>snv@niidi.ruMonakhovaNina E.<p>Researcher, Department of Clinical Laboratory Diagnostics</p>kldidi@mail.ruGrigorievStepan G.<p>MD, PhD, Dr Med Sci, Senior Researcher, Scientific and Organizational Department; Senior Researcher of the Research Department of the Research Center</p>wwave@yandex.ruPediatric Research and Clinical Center for Infectious DiseasesSt. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian FederationS.M. Kirov Military Medical Academy1308201910317241308201913082019Copyright © 2019, Bukhalko M.A., Skripchenko E.Y., Alekseeva L.A., Skripchenko N.V., Monakhova N.E., Grigoriev S.G.2019<p>The relevance of studying the provision of vitamin D in children with inflammatory diseases of the central nervous system (CNS) is due to a high prevalence of vitamin D deficiency conditions in children population, which, according to current literature data, leads to the imbalance of the immune system and a predisposition to a severe disease course, chronization of the process, development of autoimmune pathology. The study of the concentration of neurospecific proteins (NSP) in blood serum and cerebrospinal fluid (CSF) has been recently used to analyze the degree and nature of nervous tissue damage in case of various CNS diseases. The study included investigation of blood serum and CSF samples obtained from 107 children (34 with encephalitis, 28 with disseminated encephalomyelitis (DEM), 20 with multiple sclerosis (MS), 25 control group). Determination of vitamin D levels (25(OH)D) was performed by the method of electrochemiluminescence immunoassay, concentrations of myelin basic protein, neuron-specific enolase, S100 protein and glial fibrillary acidic protein by ELISA method. A decrease in the concentration of vitamin D under 30 ng/ml was found in 95% of children with inflammatory diseases of the central nervous system, while the severity of the deficiency of 25(OH)D was associated with the severity of the disease course. In the early stages of the disease in all groups, a significant increase in the level of the main myelin protein was found, while an increase in the concentration of other NSP was observed less frequently and was associated with a severe and complicated course of the disease. Correlations of different intensity and direction between NSP and 25(OH)D were found, which indicates their importance in the pathogenesis of inflammatory diseases of CNS.</p>encephalitisdisseminated encephalomyelitismultiple sclerosisvitamin Dmyelin basic proteinneuron-specific enolaseS100 proteinglial fibrillar acid proteinэнцефалитдиссеминированный энцефаломиелитрассеянный склерозвитамин Dосновной белок миелинанейронспецифическая енолазабелок S100глиальный фибриллярный кислый белок[Алексеева Л.А., Скрипченко Н.В., Бессонова Т.В., и др. Патогенетические механизмы демиелинизирующих заболеваний центральной нервной системы у детей // Журнал неврологии и психиатрии им. C.C. Корсакова. – 2014. – Т. 114. – № 6. – С. 48–52. [Alekseeva LA, Skripchenko NV, Bessonova TV, et al. Pathogenetic mechanisms of demyelinating diseases of the central nervous system in children. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2014;114(6):48-52. 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