Pediatrician (St. Petersburg)Pediatrician (St. Petersburg)2079-78502587-6252Eco-Vector6235110.17816/PED11557-65Research ArticleGiant hepatic hemangiomas in newborns, review literature. Two cases of giant congenital hepatic hemangiomasPodkamenevAlexey V.<p>MD, PhD, Dr. Sci. (Med.), Associate Professor, Department of Surgical Diseases of Childhood</p>podkamenev@hotmail.comSyrtsovaArina R.<p>Pediatric Surgeon, Operating Department, Perinatal Center</p>syrcovaarina@gmail.comTiRoman A.<p>Pediatric Surgeon, Operating Department, Perinatal center</p>sprut009@yandex.ruKuzminykhSvetlana V.<p>Pediatric Surgeon, Operating Department, Perinatal center</p>svkuzminykh@yandex.ruKondratievGleb V.<p>Pediatric Oncologist, Assistant Professor, Department of With a Course of Radiation Oncology Diagnostics and Radiotherapy</p>spbgvk@mail.ruMyznikovaIrina V.<p>Neonatologist, Head of the Department of Pathology of Newborns and Infants, Perinatal center</p>irinayurko2014@yandex.ruKostylevAlexandr A.<p>Pediatric Oncologist, Pediatric Oncologist, Department of Oncohematology</p>aka181091@gmail.comSt. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian FederationSt. Petersburg’s Children’s City Multidisciplinary Clinical Specialized Center of High Medical Technologies3012202011557650103202101032021Copyright © 2020, Podkamenev A.V., Syrtsova A.R., Ti R.A., Kuzminykh S.V., Kondratiev G.V., Myznikova I.V., Kostylev A.A.2020<p>Hemangiomas are the most frequent tumors of childhood age. In the first year of life their prevalence is 1012%. Among premature children, the prevalence of hemangiomas correlates with the degree of prematurity. Liver hemangiomas are a wide range of benign vascular formations that can acquire both malignant course and capable of spontaneous regression. Small-sized hemangiomas generally do not require specific treatment and proceed asymptomally. Large-sized formations can cause life-threatening conditions such as severe thrombocytopenia with coagulopathy (KazabahMerrit syndrome), anaemia, tumor hemorrhage, spontaneous and traumatic tumor breaks, heart failure associated with intra-tumor bypass of blood flow, abdominal compression syndrome, severe hypothyroidism. Diagnosis of this pathology is carried out on the basis of a set of data of medical imaging, laboratory diagnostics and clinical picture. This review presents key points of general classification, the most characteristic diagnostic signs, as well as basic algorithms of treatment of liver hemangiomas in newborns and children of the first year of life. There are also described 2 clinical cases of newborns with giant liver hemangiomas, which were examined and treated in the pathology department of newborns and infants of Perinatal Center of St. Petersburg State Pediatric Medical University with a description of the peculiarities of the course of each of them.</p>hemangiomahemangioendotheliomalivernewbornsgiant hepatic hemangiomapropranololcoagulopathyKazabah–Merritt syndromethrombocytopeniaгемангиомагемангиоэндотелиомапеченьноворожденныегигантская гемангиома печенипропранололкоагулопатия потреблениясиндром Казабаха – Мерритатромбоцитопения[Скипенко О.Г., Камалов Ю.Р., Ховрин В.В., и др. 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