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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatrician (St. Petersburg)</journal-id><journal-title-group><journal-title xml:lang="en">Pediatrician (St. Petersburg)</journal-title><trans-title-group xml:lang="ru"><trans-title>Педиатр</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2079-7850</issn><issn publication-format="electronic">2587-6252</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">636254</article-id><article-id pub-id-type="doi">10.17816/PED15293-100</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical observation</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинический случай</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Erythema nodosum in Gianotti–Crosti syndrome associated with cytomegalovirus infection: a case report</article-title><trans-title-group xml:lang="ru"><trans-title>Узловатая эритема на фоне синдрома Джанотти–Крости, ассоциированного с цитомегаловирусной инфекцией: клинический случай</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title/></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-1733-9090</contrib-id><contrib-id contrib-id-type="spin">5291-0430</contrib-id><name-alternatives><name xml:lang="en"><surname>Pronskaya</surname><given-names>Olga A.</given-names></name><name xml:lang="ru"><surname>Пронская</surname><given-names>Ольга Александровна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant Professor, Department of Pediatrics, Paediatrics Centre</p></bio><bio xml:lang="ru"><p>ассистент, кафедра педиатрии, врач-педиатр</p></bio><email>ms.fedina.olga@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4636-1819</contrib-id><contrib-id contrib-id-type="spin">4932-4641</contrib-id><name-alternatives><name xml:lang="en"><surname>Bogomazov</surname><given-names>Alexey D.</given-names></name><name xml:lang="ru"><surname>Богомазов</surname><given-names>Алексей Дмитриевич</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Cand. Sci. (Medicine), Associate Professor, Department of Pediatrics</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, доцент, кафедра педиатрии</p></bio><email>bogomazov71@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3435-0039</contrib-id><contrib-id contrib-id-type="spin">2016-3260</contrib-id><name-alternatives><name xml:lang="en"><surname>Bets</surname><given-names>Olga G.</given-names></name><name xml:lang="ru"><surname>Бец</surname><given-names>Ольга Георгиевна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant Professor, Department of Pediatrics</p></bio><bio xml:lang="ru"><p>ассистент, кафедра педиатрии</p></bio><email>Bec_olga@rambler.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-0814-233X</contrib-id><contrib-id contrib-id-type="spin">3607-0269</contrib-id><name-alternatives><name xml:lang="en"><surname>Tynnikova</surname><given-names>Valeria V.</given-names></name><name xml:lang="ru"><surname>Тынникова</surname><given-names>Валерия Витальевна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>6<sup>th</sup> year student, Pediatrics Faculty</p></bio><bio xml:lang="ru"><p>студентка 6-го курса, педиатрический факультет</p></bio><email>tynnikovavv@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kursk State Medical University</institution></aff><aff><institution xml:lang="ru">Курский государственный медицинский университет</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Zhiveli Paediatrics Centre</institution></aff><aff><institution xml:lang="ru">Центр педиатрии «Живели»</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Kursk State Medical University</institution></aff><aff><institution xml:lang="ru">Курский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2024</year></pub-date><volume>15</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>93</fpage><lpage>100</lpage><history><date date-type="received" iso-8601-date="2024-09-19"><day>19</day><month>09</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-09-19"><day>19</day><month>09</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2024,</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/pediatr/article/view/636254">https://journals.eco-vector.com/pediatr/article/view/636254</self-uri><abstract xml:lang="en"><p>Gianotti–Crosti syndrome and erythema nodosum can be triggered by many different infections. These conditions are rare, especially in combination with each other, and therefore require a competent approach to differential diagnosis and identification of the cause. This article describes a case of a rare combination of atypical nodular erythema and Gianotti–Crosti syndrome with cytomegalovirus infection. A 6-year-old patient was under outpatient treatment for acute respiratory viral infections and exanthema. The child had an aggravated family history of atopy. Acute cytomegalovirus infection was laboratory confirmed. The diagnosis was made: “Cytomegalovirus disease. Infantile papular acrodermatitis (Gianotti–Crosti syndrome)”. After 7 days, the symptoms of acrodermatitis resolved, but papular elements persisted and new hyperemic papular-vesicular rashes appeared. After 3 weeks, nodular erythema developed against the background of the existing elements. The clinical diagnosis was: “Erythema nodosum. Cytomegalovirus infection. Infantile papular acrodermatitis”. The diagnosis was confirmed after consultation with a rheumatologist. The prescribed treatment had no effect on the duration of the disease. Unusuality of erythema nodosum was manifested as absence of symptoms of acute respiratory viral infection, joint and muscle pain the day before. The patient was under paediatric care for 3.5 months, by the end of which the papular acrodermatitis and erythema nodosum resolved almost simultaneously. Paediatricians should consider the possibility of combining Gianotti–Crosti syndrome and erythema nodosum for timely diagnosis.</p></abstract><trans-abstract xml:lang="ru"><p>Возникновение синдрома Джанотти–Крости и узловатой эритемы может быть спровоцировано множеством различных инфекций. Данные состояния возникают редко, особенно в сочетании друг с другом, поэтому требуют грамотного подхода к дифференциальной диагностике и установлению причины возникновения. В статье приводится описание случая редкого сочетания нетипично протекающей узловатой эритемы и синдрома Джанотти–Крости, возникших на фоне цитомегаловирусной инфекции. Пациент в возрасте 6 лет находился на амбулаторном лечении по поводу ОРВИ и возникшей на ее фоне экзантемы. У ребенка отягощен семейный атопический анамнез. Лабораторно подтверждена острая цитомегаловирусная инфекция. Поставлен диагноз: «Цитомегаловирусная болезнь. Детский папулезный акродерматит (синдром Джанотти–Крости)». Спустя 7 дней симптомы ОРВИ разрешились, при этом продолжали сохраняться папулезные элементы и появились новые гиперемированные папулезно-везикулезные высыпания. Через 3 нед. на фоне существующих элементов развилась узловатая эритема. Поставлен клинический диагноз: «Узловатая эритема. Цитомегаловирусная инфекция. Детский папулезный акродерматит». Диагноз подтвержден после консультации ревматолога. Назначенное лечение не оказало влияния на длительность заболевания. Необычность узловатой эритемы проявлялась в виде отсутствия симптомов ОРВИ, суставных и мышечных болей накануне. Пациент находился под наблюдением педиатра 3,5 мес., к концу которых проявления папулезного акродерматита и узловатой эритемы разрешились практически одновременно. Врачам-педиатрам необходимо учитывать вероятность сочетания синдрома Джанотти–Крости и узловатой эритемы для своевременной постановки диагноза.</p></trans-abstract><trans-abstract xml:lang="zh"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>clinical case</kwd><kwd>cytomegalovirus infection</kwd><kwd>erythema nodosum</kwd><kwd>papular acrodermatitis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>клинический случай</kwd><kwd>цитомегаловирусная инфекция</kwd><kwd>узловатая эритема</kwd><kwd>папулезный акродерматит</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Cohen BA. Pediatric dermatology. 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