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Chicken pox can be both acquired and congenital. The information is presented in the form of a diagram on the incidence of chickenpox in St. Petersburg, which shows that among children, the most common are children aged 3 to 6 years. A brief etiology of the varicella virus, a clinical picture, describing the typical and atypical forms of the disease. Due to the airborne pathway and the high infectivity of the infection, there is a risk of contracting seronegative pregnant women, which is 50%. It has been established that for 1,000 deliveries there are from 1 to 5 cases of chicken pox. In addition, the flow of chicken pox and lethality depends on the possibility of transmitting from mother to child protective specific maternal antibodies. Features of infection in pregnant women and fetus, the severity of intrauterine infection, depending on the timing of infection are described. The characteristics of varicella and neonatal chickenpox syndrome, as well as nonspecific clinical manifestations of the infectious process in the newborn are presented. We describe our own clinical observation of congenital varicella in a 6-day-old child, born from a mother who fell ill four days before the birth. The inclusion in the complex therapy of children with congenital chickenpox recombinant interferon-α2β with antioxidants (viferon rectal suppositories) contributes to the rapid positive dynamics of clinical symptoms, easier flow, prevents the layering of acute respiratory infections, reduces the material costs of treatment.