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The purpose of study was to refine frequency of etiological factors and characteristics of congenital pseudarthrosis of tibia (CPT). Materials and Methods. The analysis of complex research (anamnestic, clinical, radiological, physiological, morphological) of 190 patients with CPT. Results. It was found that the causes of disease are: neurofibromatosis, myelodysplasia and fibrous dysplasia. In neurofibromatosis and myelodysplasia in the basis for false joints there are neurotrophic disorders. Typically a latent pseudarthrosis occurs at birth with the progression of deformity and thinning of the affected bone. Provoking factor of pseudarthrosis is a pathological fracture. Deformities, limb shortening, significant thinning and sclerosis of ends of bone fragments, degenerative changes in bone tissue throughout the diaphysis and epiphysis, lowered bone growth, weak ossification at the ends of bone fragments up to complete absence are observed. In fibrous dysplasia the provoking factor is a pathological fracture. The ends of the bone fragments are thickened, sclerotic, they reveal foci of fibrous dysplasia. Conclusion. It was found that two groups of CPT are: neurotrophic and dysplastic types. Neurotrophic CPT develops against neurofibromatosis and myelodysplasia, dysplasric one - against fibrous dysplasia. Features of the development and course of congenital pseudarthrosis of tibia have a direct correlation with the etiologic factor.

About the authors

Alexander Pavlovich Pozdeev

FSBI “Scientific and Research Institute for Children’s Orthopedics n. a. G. I. Turner” under the Ministry of Health of the Russian Federation

Email: prof.pozdeev@mail.ru
MD, DMedSc, Professor, chief research associate of the department of bone pathology

Ekaterina Anatolievna Zakharyan

State budget institution of higher education “North-Western State Medical University n. a. I. I. Mechnikov” under the Ministry of Public Health of the Russian Federation

Email: zax-2008@mail.ru
MD, PhD student of the chair of children’s traumatology and orthopedics


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