Prospects of hydroxyapatite-based nanomaterials application synthesized by layer-by-layer method for pediatric traumatology and orthopedics

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Abstract

The present brief review focuses on the features of the Layer-by-Layer (LbL) synthesis of coatings containing hydroxyapatite nanoparticles and assesses their use in solving several biomedical problems. This work provides the state-of-art of this field. This method is based on the sequential chemical adsorption of reagents on the substrate surface that makes it possible to apply nanolayers of the specified composition on the surface of a wide range of substrates of complex shape, to control the thickness of the synthesized layers accurately at the nanometer level. It also enables the modification of surface characteristics, including roughness, hydrophilicity, and surface charge, and allows “artificially” constructed multilayers consisting of hybrid organic and inorganic substances to be obtained. The experimental material presented in the review demonstrates the effectiveness of LbL synthesis for creating new 3D scaffolds as bone substitutes, coatings on the surface of metal implants, and drug delivery systems. A promising direction for the development of LbL synthesis is the creation of methods that involve ion-substituted hydroxyapatites as reagents. Success in this area can pave the way for significant advances in biomedicine and open new opportunities for creating a new generation of structures that mimic the structural, compositional, and mechanical properties of the bone mineral phase.

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About the authors

Aleksandra A. Meleshko

Institute of Chemistry St. Petersburg State University

Author for correspondence.
Email: alya_him@mail.ru
ORCID iD: 0000-0002-7010-5209

PhD in Technical Sciences, Researcher

Russian Federation, 198504, St. Petersburg, Petergof, Universitetskii prospect 26

Valeri P. Tolstoy

Institute of Chemistry St. Petersburg State University

Email: v.tolstoy@spbu.ru
ORCID iD: 0000-0003-3857-7238

D.Sc. in Chemistry, senior researcher, Professor

Russian Federation, 198504, St. Petersburg, Petergof, Universitetskii prospect 26

Gennady E. Afinogenov

Saint Petersburg State University

Email: gennady-afinogenov@yandex.ru
ORCID iD: 0000-0003-1273-7651

MD, PhD, D.Sc., Professor, Professor of the Department of Oral and Maxillofacial Surgery and Surgical Dentistry

Russian Federation, 7/9, Universitetskaya embankment, Saint-Petersburg, 199034

Aleksandra S. Levshakova

Institute of Chemistry, Saint Petersburg State University

Email: sashkeens@gmail.com
ORCID iD: 0000-0001-8164-5174

graduate student

Russian Federation, 198504, St. Petersburg, Petergof, Universitetskii prospect 26

Anna G. Afinogenova

Saint Petersburg State University; Saint Petersburg Pasteur Research Institute of Epidemiology and Mictobiology

Email: spbtestcenter@mail.ru
ORCID iD: 0000-0001-8175-0708

Professor of the Department of Oral and Maxillofacial Surgery and Surgical Dentistry; D.Sc. in Biology, Senior Research Associate

Russian Federation, 7/9, Universitetskaya embankment, Saint-Petersburg, 199034; 14, Mira street, Saint Petersburg, 197101

Vladislav P. Muldiyarov

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

Email: Muldiyarov@inbox.ru
ORCID iD: 0000-0002-3988-7193

MD, Clinical Resident

Russian Federation, 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603

Sergei V. Vissarionov

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

Email: vissarionovs@gmail.com
ORCID iD: 0000-0003-4235-5048

MD, PhD, D.Sc., Professor, Corresponding Member of RAS, Deputy Director for Research and Academic Affairs, Head of the Department of Spinal Pathology and Neurosurgery

Russian Federation, 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603

Stanislav A. Linnik

North-Western State Medical University named after I.I. Mechnikov

Email: stanislavlinnik@mail.ru
ORCID iD: 0000-0002-4840-6662

MD, PhD, D.Sc., Professor, Professor of the Department of traumatology and orthopedics

Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015

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Supplementary files

Supplementary Files
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2. Fig. 5. Schematic representation of layered deposition on a spiral framework of PLGA cationic chitosan (indicated in red) and anionic hydroxyapatite (indicated in blue)

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3. Fig. 6. Schematic diagram of the stages of layer-by-layer chemical assembly of nanoparticles with core-shell morphology containing hydroxyapatite (HAP), sodium alginate (ALG), polyallylamine (PAA) and alendronate

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4. Fig. 1. Hydroxyapatite preparation methods

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5. Fig. 2. Schematic representation of examples of the uses of hydroxyapatite in biomedicine

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6. Fig. 3. The process of producing a composite 3D scaffold from a mixture of hydroxyapatite (HAp) with gelatin (Gel) followed by surface modification by layer-by-layer synthesis using solutions of chitosan (CHI) and hyaluronic acid (HA)

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7. Fig. 5. Schematic representation of layer-by-layer deposition on a pLGA spiral scaffold of cationic chitosan (indicated in red) and anionic hydroxyapatite (indicated in blue)

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8. Fig. 6. Schematic representation of the stages of a layered chemical assembly of nanoparticles with core–shell morphology, containing hydroxyapatite (HAp), sodium alginate (ALG), polyallylamine (PAA), and alendronate

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Copyright (c) 2020 Meleshko A.A., Tolstoy V.P., Afinogenov G.E., Levshakova A.S., Afinogenova A.G., Muldiyarov V.P., Vissarionov S.V., Linnik S.A.

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