Urology reports (St. - Petersburg)Urology reports (St. - Petersburg)Урологические ведомостиUrology reports (St. - Petersburg)2225-90742687-1416Eco-Vector5816510.17816/uroved58165ReviewsНаучные обзорыReviewsReview ArticlePhotodynamic diagnostics of non-muscle-invasive bladder cancerФотодинамическая диагностика немышечно-инвазивного рака мочевого пузыря非肌层浸润性膀胱癌的光动力荧光诊断研究KasymovBahtijar G.КасымовБахтияр Галыулы
Kazakhstan

Urologist, Department of Urology

врач-уролог отдела урологии

b_kasymov@bk.ru6224-3395ShanazarovNasrulla A.ШаназаровНасрулла Абдуллаевич
Kazakhstan

Dr. Sci. (Med), Professor, Oncologist, Deputy Director of Science and Strategy Development

доктор медицинских наук, профессор, врач-онколог, заместитель директора по науке и стратегии развития

nasrulla@inbox.ruMuratovTimur M.МуратовТимур Муратулы
Kazakhstan

Cand. Sci. (Med.), Urologist, First Deputy Director

кандидат медицинских наук, врач-уролог, первый заместитель директора

ttimeke@mail.ruDaniyarovaGulnur D.ДанияроваГулнур Данияркызы
Kazakhstan

Specialist of the Center for Robotic Surgery

специалист центра роботизированной хирургии

gulnur_011091@mail.ruZhumakayevAkylbek M.ЖумакаевАкылбек Муратбекович
Kazakhstan

Urologist, Oncologist

врач-уролог, врач-онколог

Akylbek_89@mail.ruhttps://orcid.org/0000-0003-1050-6198571961241486806-7913KyzlasovPavel S.КызласовПавел Сергеевич
Russian Federation

Dr. Sci. (Med), Professor of the Department Urology and Andrology of the Biomedical University of Innovation and Continuing Education, Head of Center of Urology and Andrology

доктор медицинских наук, профессор кафедры урологии и андрологии Медико-биологического университета инноваций и непрерывного образования, руководитель Центра урологии и андрологии

dr.kyzlasov@mail.ruhttps://fmbafmbc.ru/centers/urology/https://orcid.org/0000-0002-2422-79425422-8789MustafayevAli Telman ogluМустафаевАли Тельман оглы
Russian Federation

Postgraduate Student, Department Urology and Andrology of the Biomedical University of Innovation and Continuing Education

аспирант кафедры урологии и андрологии медико-биологического университета инноваций и непрерывного образования

dr.mustafayevat@gmail.comhttps://orcid.org/0000-0002-4911-6018571961172119602-7775SlesarevskayaMargarita N.СлесаревскаяМаргарита Николаевна
Russian Federation

Cand. Sci. (Med.)

кандидат медицинских наук, старший научный сотрудник

mns-1971@yandex.ruhttps://www.1spbgmu.ru/ru/universitet/strustura/kafedry/106-glavnaya/3905-slesarevskaya-margarita-nikolaevnahttps://orcid.org/0000-0002-7724-7832568786813002684-4070KuzminIgor V.КузьминИгорь Валентинович
Russian Federation

Dr. Sci. (Med.), Professor of the Department of Urology

доктор медицинских наук, профессор кафедры урологии

kuzminigor@mail.ruhttps://www.ooorou.ru/ru/users/kuzminigor-mail-ru.htmlAl-ShukriSalman K.Аль-ШукриСальман Хасунович
Russian Federation

Dr. Sci. (Med.), Professor, Head of the Department of Urology

доктор медицинских наук, профессор, заведующий кафедрой урологии

alshukri@mail.ruMedical Centre Hospital of President’s affairs administration of the Republic of KazakhstanБольница Медицинского центра Управления Делами Президента Республики Казахстан на праве хозяйственного веденияMultidisciplinary medical center of the akimat of the city of Nur-SultanМногопрофильный медицинский центр акимата города Нур-СултанBurnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of RussiaМедико-биологический университет инноваций и непрерывного образования Государственного научного центра «Федеральный медицинский биофизический центр им. А.И. Бурназяна»Academician I.P. Pavlov First St. Petersburg State Medical UniversityПервый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова07072021180820211121631741301202104072021Copyright ©; 2021, Eco-VectorCopyright ©; 2021, ООО «Эко-Вектор»Copyright ©; 2021, Kasymov B., Shanazarov N., Muratov T., Zhumakayev A., Daniyarova G., Kyzlasov P., Mustafayev A., Kuzmin I., Al-Shukri S.2021Eco-VectorООО «Эко-Вектор»Kasymov B., Shanazarov N., Muratov T., Zhumakayev A., Daniyarova G., Kyzlasov P., Mustafayev A., Kuzmin I., Al-Shukri S.https://journals.eco-vector.com/uroved/article/view/58165

The review is devoted to the application of photodynamic diagnosis of non-muscle invasive bladder cancer. The recent data on the mechanism of action of photosensitizers, the method of performing fluorescence cystoscopy are presented, and the results of clinical studies of the application of photodynamic diagnostics in practical medicine are presented. It has been shown that photodynamic diagnostics significantly increases the efficiency of detecting bladder cancer in comparison with standard cystoscopy. The application of this method is especially valuable in cases of carcinoma in situ and multifocal growth of urothelial tumors. Improvement in diagnostics makes it possible to increase the radicality of surgical treatment and to increase the duration of the relapse-free period.

Обзорная статья посвящена применению фотодинамической диагностики немышечно-инвазивного рака мочевого пузыря. Приведены современные данные о механизме действия фотосенсибилизаторов, методике выполнения флуоресцентной цистоскопии, представлены результаты клинических исследований применения фотодинамической диагностики в практической медицине. Показано, что фотодинамическая диагностика существенно увеличивает эффективность выявления рака мочевого пузыря по сравнению со стандартной цистоскопией. Особенно ценным является применение данного метода в случаях carcinoma in situ и мультифокальном росте уротелиальных опухолей. Улучшение диагностики позволяет повысить радикальность хирургического лечения и увеличить длительность безрецидивного периода.

本文就光动力学在非肌层浸润性膀胱癌诊断中的应用作一综述。介绍了光敏剂作用机理的现代数据，荧光膀胱镜检查的方法，在实际医学中使用光动力学诊断的临床研究结果。结果表明，与标准膀胱镜检查相比，光动力诊断显著提高了膀胱癌的检测效率。这种方法在原位癌（carcinoma in situ）和多局灶尿路上皮肿瘤的病例中尤其有价值。提高诊断水平可以提高手术治疗的根治性和延长无 复发期。

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