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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Urology reports (St. - Petersburg)</journal-id><journal-title-group><journal-title xml:lang="en">Urology reports (St. - Petersburg)</journal-title><trans-title-group xml:lang="ru"><trans-title>Урологические ведомости</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Urology reports (St. - Petersburg)</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2225-9074</issn><issn publication-format="electronic">2687-1416</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">676911</article-id><article-id pub-id-type="doi">10.17816/uroved676911</article-id><article-id pub-id-type="edn">ROYYUY</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>Reviews</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Modern approaches to phytotherapy in uric acid nephrolithiasis</article-title><trans-title-group xml:lang="ru"><trans-title>Современные подходы к фитотерапии при уратном нефролитиазе</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title/></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5741-6408</contrib-id><contrib-id contrib-id-type="spin">4528-7765</contrib-id><name-alternatives><name xml:lang="en"><surname>Neymark</surname><given-names>Alexander I.</given-names></name><name xml:lang="ru"><surname>Неймарк</surname><given-names>Александр Израилевич</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>neimark.a@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9425-2668</contrib-id><contrib-id contrib-id-type="spin">2746-7593</contrib-id><name-alternatives><name xml:lang="en"><surname>Belokurov</surname><given-names>Sergei S.</given-names></name><name xml:lang="ru"><surname>Белокуров</surname><given-names>Сергей Сергеевич</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Pharmacy)</p></bio><bio xml:lang="ru"><p>канд. фармацевт. наук</p></bio><email>ser.j.b.777@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8009-3777</contrib-id><contrib-id contrib-id-type="spin">7886-8442</contrib-id><name-alternatives><name xml:lang="en"><surname>Neymark</surname><given-names>Boris A.</given-names></name><name xml:lang="ru"><surname>Неймарк</surname><given-names>Борис Александрович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>neimark.b@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3937-7270</contrib-id><contrib-id contrib-id-type="spin">4800-8255</contrib-id><name-alternatives><name xml:lang="en"><surname>Nozdrachev</surname><given-names>Nikolay A.</given-names></name><name xml:lang="ru"><surname>Ноздрачев</surname><given-names>Николай Александрович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><email>nozdrachevuro@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3500-3052</contrib-id><contrib-id contrib-id-type="spin">3874-6429</contrib-id><name-alternatives><name xml:lang="en"><surname>Kalnitsky</surname><given-names>Artem S.</given-names></name><name xml:lang="ru"><surname>Кальницкий</surname><given-names>Артем Сергеевич</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Biology)</p></bio><bio xml:lang="ru"><p>канд. биол. наук</p></bio><email>artem_kalnitsky@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4401-3722</contrib-id><contrib-id contrib-id-type="spin">4557-2065</contrib-id><name-alternatives><name xml:lang="en"><surname>Kovaleva</surname><given-names>Yulia S.</given-names></name><name xml:lang="ru"><surname>Ковалёва</surname><given-names>Юлия Сергеевна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Assistant Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, доцент</p></bio><email>julia_jsk@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-4218-360X</contrib-id><name-alternatives><name xml:lang="en"><surname>Maslova</surname><given-names>Elvira V.</given-names></name><name xml:lang="ru"><surname>Маслова</surname><given-names>Эльвира Валерьевна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>elviravalerevna0922@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Altai State Medical University</institution></aff><aff><institution xml:lang="ru">Алтайский государственный медицинский университет</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Altai Medical State University</institution></aff><aff><institution xml:lang="ru">Алтайский государственный медицинский университет</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-10-01" publication-format="electronic"><day>01</day><month>10</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-11-15" publication-format="electronic"><day>15</day><month>11</month><year>2025</year></pub-date><volume>15</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>307</fpage><lpage>313</lpage><history><date date-type="received" iso-8601-date="2025-03-21"><day>21</day><month>03</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-10-01"><day>01</day><month>10</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025,</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2028-11-15"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://eco-vector.com/for_authors.php#07</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/uroved/article/view/676911">https://journals.eco-vector.com/uroved/article/view/676911</self-uri><abstract xml:lang="en"><p>The article discusses pathogenetic and clinical aspects of phytotherapy in patients with urolithiasis. Phytotherapy plays an important role in the treatment and metaphylaxis of uric acid nephrolithiasis. This is attributed to its efficacy and safety, including during long-term use. The article examines currently available herbal formulations with proven clinical efficacy. Herbal formulations used in patients with uric acid nephrolithiasis typically include components such as extracts of Java tea leaves (<italic>Orthosiphon stamineus</italic>), <italic>Alpinia officinarum</italic>, field horsetail, and the roots and rhizomes of Levisticum officinale. These plants are well known for their beneficial properties and have long been used in traditional medicine. The active ingredients of these herbal formulations, such as saponins, flavonoids, terpenes, fatty acids, phenolic glycosides, caffeic acid metabolites (rosmarinic and lithospermic acids), tannins, and vitamins (notably, ascorbic acid is present in all the products mentioned), have a significant impact on their therapeutic effect. The herbal formulations exhibit diuretic, anti-inflammatory, antibacterial, and antispasmodic properties. The development of new, effective herbal formulations for the treatment of uric acid nephrolithiasis, as well as the study of their therapeutic mechanisms, remain highly relevant in modern urology.</p></abstract><trans-abstract xml:lang="ru"><p>Фитопрепрараты широко используются для лечения и метафилактики мочекаменной болезни, в том числе уратного литиаза. Это связано как с их эффективностью, так и безопасностью, в том числе при длительном применении. При этом многие аспекты механизма лечебного действия растительных композиций остаются неясными. Представлен анализ существующих на рынке растительных композиций, доказавших свою клиническую эффективность. В состав фитопрепаратов, используемых у больных уратным литиазом, чаще всего входят такие компоненты как экстракт листьев почечного чая (ортосифон тычиночный), альпинии лекарственной, хвоща полевого, корни и корневища любистока лекарственного. Эти растения известны своими полезными свойствами и давно используются в народной медицине. Большое значение в достижении определенного терапевтического эффекта имеет действующее начало указанных компонентов фитопрепаратов: сапонины, флавоноиды, терпены, жирные кислоты, фенолгликозиды, метаболиты кофейной кислоты (розмариновая и литоспермовая кислоты), дубильные вещества, витамины (в частности, во всех выделенных препаратах присутствует аскорбиновая кислота). Используемые лекарственные композиции обладают мочегонным, противовоспалительным, антибактериальным и спазмолитическим эффектами. Разработка новых эффективных растительных композиций для лечения больных уратным литиазом и изучение механизма их терапевтического действия представляются весьма актуальными задачами современной урологии.</p></trans-abstract><trans-abstract xml:lang="zh"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>uric acid nephrolithiasis</kwd><kwd>phytotherapy</kwd><kwd>urolithiasis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>уратный нефролитиаз</kwd><kwd>фитотерапия</kwd><kwd>мочекаменная болезнь</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Sorokin I, Mamoulakis C, Miyazawa K, et al. Epidemiology of stone disease across the world. World J Urol. 2017;35(9):1301–1320. doi: 10.1007/s00345-017-2008-6</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Wiederkehr MR, Moe OW. Uric acid nephrolithiasis: A systemic metabolic disorder. 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