Urology reports (St. - Petersburg)Urology reports (St. - Petersburg)Урологические ведомостиUrology reports (St. - Petersburg)2225-90742687-1416Eco-Vector8381510.17816/uroved83815Original study articlesОригинальные исследованияResearch ArticlePredictive value of inflammatory indices LMR, PLR and NLR in patients with muscle-invasive bladder cancerПрогностическое значение воспалительных индексов LMR, PLR и NLR у пациентов с мышечно-инвазивным раком мочевого пузыряhttps://orcid.org/0000-0002-2858-531770052531735070-9526GorelovAndrei I.ГореловАндрей ИгоревичGorelovAndrei I.
Russian Federation

Dr. Sci. (Med.), Professor of the Department of Hospital Surgery with a Course of Urology, Head of Urological Unit

д-р мед. наук, профессор кафедры госпитальной хирургии c курсом урологии, заведующий отделением урологии

Dr. Sci. (Med.), Professor of the Department of Hospital Surgery with a Course of Urology, Head of Urological Unit

gorelov_a_i@mail.ruhttps://med.spbu.ru/prepodavateli/913-gorelov-andrej-igorevich.htmlhttps://orcid.org/0000-0002-2556-33903748-7129ZhuravskiiDmitriy A.ЖуравскийДмитрий АлександровичZhuravskiiDmitriy A.
Russian Federation

Postgraduate student

аспирант

Postgraduate student

zhuravskiy.spbu@gmail.comhttps://orcid.org/0000-0002-7010-7562572028120748568-9004GorelovaAnna A.ГореловаАнна АндреевнаGorelovaAnna A.
Russian Federation

Cand. Sci. (Med.), Assistant Professor of the Department of Hospital Surgery with a Course of Urology

канд. мед. наук, ассистент кафедры госпитальной хирургии с курсом урологии, ст. н. с.

Cand. Sci. (Med.), Assistant Professor of the Department of Hospital Surgery with a Course of Urology

gorelovauro@gmail.comSaint Petersburg State UniversityСанкт-Петербургский государственный университетSaint Petersburg State UniversityCity Pokrovskaya HospitalГородская Покровская больницаCity Pokrovskaya HospitalSaint-Petersburg UniversityСанкт-Петербургский государственный университетSaint-Petersburg UniversitySt. Petersburg Research Institute of PhthisiopulmonologyСанкт-Петербургский научно-исследовательский институт фтизиопульмонологииSt. Petersburg Research Institute of Phthisiopulmonology23112021151220211142852942610202123112021Copyright ©; 2021, Gorelov A.I., Zhuravskii D.A., Gorelova A.A.Copyright ©; 2021, Горелов А.И., Журавский Д.А., Горелова А.АCopyright ©; 2021, Gorelov A.I., Zhuravskii D.A., Gorelova A.A.2021Gorelov A.I., Zhuravskii D.A., Gorelova A.A.Горелов А.И., Журавский Д.А., Горелова А.АGorelov A.I., Zhuravskii D.A., Gorelova A.A.https://creativecommons.org/licenses/by-nc-nd/4.0/https://journals.eco-vector.com/uroved/article/view/83815

BACKGROUND: Increasing the efficiency of predicting the results of treatment of patients with bladder cancer is one of the important tasks of modern urology.

AIM: Our aim was to identify and evaluate the association between the most significant clinical, morphological and immunological markers and survival of muscle-invasive bladder cancer patients treated with radical cystectomy. We also developed an algorithm for diagnosis and treatment of patients with muscle-invasive bladder cancer.

MATERIALS AND METHODS: This retrospective study included 100 muscle-invasive bladder cancer patients, who underwent radical cystectomy between 1995 and 2013. The study endpoints were overall survival.

RESULTS: Univariable analysis revealed that continuous (Lymphocyte-monocyte ratio), PLR (platelet-lymphocyte ratio) и NLR (neutrophil-lymphocyte ratio) were significantly associated with overall survival. On multivariable regression model analysis, continuous LMR, NLR, and PLR independently predicted both endpoints.

CONCLUSIONS: Our findings indicate that the cheap and simple blood-based biomarkers may be valuable in identifying muscle-invasive bladder cancer patients treated with radical cystectomy, who are at higher risk of all-cause mortality.

Актуальность. Повышение эффективности прогнозирования результатов лечения больных раком мочевого пузыря — одна из важных задач современной урологии.

Цель. Оценить прогностическую ценность периоперационных иммунологических маркеров LMR (lymphocyte-monocyte ratio — лимфоцитарно-моноцитарный индекс), PLR (platelet-lymphocyte ratio — тромбоцито-лимфоцитарный индекс) и NLR (neutrophil-lymphocyte ratio — нейтрофильно-лимфоцитарный индекс) у пациентов с мышечно-инвазивным раком мочевого пузыря, которым была выполнена радикальная цистэктомия.

Материалы и методы. В ретроспективное исследование были включены 100 пациентов с мышечно-инвазивным раком мочевого пузыря, перенесших радикальную цистэктомию в период с 1995 по 2013 г. Конечной точкой исследования была общая выживаемость.

Результаты. Пятилетняя общая выживаемость была достоверно ниже (р < 0,0001) в группах высокого риска при всех воспалительных индексах и составила 52, 57 и 45 % для PLR-, NLR- и LMR-высоких рисков соответственно. Проведение множественного регрессионного анализа показало, что анализируемые иммунологические маркеры могут использоваться для прогнозирования исходов хирургического лечения.

Выводы. Наши результаты показывают, что дешевый и простой анализ маркеров воспаления могут быть ценными для выявления пациентов высокого и низкого риска с мышечно-инвазивным раком мочевого пузыря, предсказывая эффективность хирургического лечения.

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