Urology reports (St. - Petersburg)Urology reports (St. - Petersburg)2225-90742687-1416Eco-Vector8408410.17816/uroved84084Research ArticleOpportunities of drugs based on D-mannose and herbal components in the treatment and prevention of recurrent lower urinary tract infections in womenShormanovIgor S.<p>Dr. Sci. (Med.), Professor, Head of the Department of Urology with Nephrology</p>i-s-shormanov@yandex.ruhttps://orcid.org/0000-0002-2062-0421SolovyovAndrey S.<p>Сand. Sci. (Med), Assistant of the Department of Urology with Nephrology</p>a-s-soloviev89@yandex.ruhttps://orcid.org/0000-0001-5612-3227ChirkovIvan A.<p>Clinical resident, Department of Urology with Nephrology</p>kafuro@mail.ruShchedrovDmitry N.<p>Doc. Sci. (Med.), Head of the Pediatric Urology and Andrology Unit</p>shedrov.dmitry@yandex.ruhttps://orcid.org/0000-0002-0686-0445KrasnyakStepan S.<p>Cand. Sci. (Med.), Associate Researcher of the Department of Andrology and Human Reproduction</p>krasnyakss@mail.ruhttps://orcid.org/0000-0001-9819-6299ShaderkinIgor A.<p>Cand. Sci. (Med.), Head of the Health Laboratory of the Institute of Digital Medicine</p>info@uroweb.ruhttps://orcid.org/0000-0001-8669-2674Yaroslavl State Medical UniversityRegional Pediatric Clinical HospitalResearch Institute of Urology and Interventional Radiology after named N.A. Lopatkin – branch of the National Medical Research Center of RadiologyI.M. Sechenov First Moscow State Medical University (Sechenov University)2604202212113202112202120032022Copyright © 2022, Eco-Vector2022<p><em><strong>BACKGROUND:</strong></em> Recurrent cystitis is a common form of urinary tract infections. In the treatment of this disease antibacterial drugs are usually used. At the same time, there are plant components that can be a worthy substitute for antibiotic therapy.</p>
<p><em><strong>AIM:</strong> </em>To evaluate the efficacy and safety of the biologically active complex Cystalis, containing D-mannose, grape seed extract and bearberry extract, in the treatment and prevention of recurrent cystitis in women.</p>
<p><em><strong>MATERIALS AND METHODS:</strong></em> The study included 60 women with recurrent cystitis. All patients answered the Acute Cystitis Symptom Scale (ACSS). The patients were divided into 2 groups of 30 people each. Patients of the 1st group received standard antibiotic therapy for recurrence of cystitis in accordance with the results of bacteriological examination of urine, followed by observation for 6 months. Patients of the second group instead of antibiotic therapy received the biologically active complex Cistalis one capsule (350 mg) 2 times a day for 3 months, followed by observation for 3 months.</p>
<p><em><strong>RESULTS:</strong> </em>Before the start of treatment Escherichia coli was detected in 26 patients (86.7%) in the 1<sup>st</sup> group and in 28 (93.3%) patients in the 2<sup>nd</sup> group. At a follow-up visit 30 days after the initial examination the total score on the ACSS scale in patients of the 1<sup>st </sup>group decreased from 6.6 1.4 to 0.03 0.18 points (p 0.001), in patients of the 2<sup>nd</sup> group from 6.4 1.3 to 0 (p 0.001). The sum of scores in the Quality of Life (QoL) domain in the representatives of the 1<sup>st</sup> group decreased from 6.3 1.3 to 0 (p 0.001), and in the 2<sup>nd</sup> group decresead from 5.6 1.0 also to 0 (p 0.001). In patients of both groups, the level of leukocytes and erythrocytes in the urine significantly decreased. During the 6-month follow-up period 8 recurrences of UTIs were registered in patients of the 1<sup>st</sup> group, and only 2 recurrences in patients of the 2<sup>nd</sup> group. The probability of developing a recurrence of cystitis in patients of the 2<sup>nd</sup> group was significantly lower than in patients of the 1<sup>st</sup> group (<sup>2</sup> = 4.603, p = 0.032).</p>
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