HERALD of North-Western State Medical University named after I.I. MechnikovHERALD of North-Western State Medical University named after I.I. Mechnikov2618-71162618-9704Eco-Vector11209510.17816/mechnikov112095Research ArticleDisseminated seronegative echinococcosis: difficulties of diagnosis and treatmentMazurovVadim I.<p>MD, Dr. Sci. (Med.), Professor, Academician of the RAS, Honored Scientist of the Russian Federation</p>maz.nwgmu@yandex.ruhttps://orcid.org/0000-0002-0797-2051GaidukovaInna Z.<p>MD, Dr. Sci. (Med.), Professor</p>ubp1976@list.ruhttps://orcid.org/0000-0003-3500-7256NochvayElena E.<p>MD</p>b25@zdrav.spb.ruhttps://orcid.org/0000-0002-8636-5961PetrovaMarianna S.<p>MD, Cand. Sci. (Med.)</p>alek-bychkova@yandex.ruhttps://orcid.org/0000-0001-5261-6614InamovaOksana V.<p>MD, Cand. Sci. (Med.)</p>alek-bychkova@yandex.ruhttps://orcid.org/0000-0001-9126-3639MazurenkoSergey O.<p>MD, Dr. Sci. (Med.), Professor</p>b4@zdrav.spb.ruhttps://orcid.org/0000-0002-1915-2237PetrovaYulia A.<p>MD</p>b16@mariin.ruhttps://orcid.org/0000-0002-2675-392XBychkovaAlexandra S.alek-bychkova@yandex.ruhttps://orcid.org/0000-0002-6275-2123VorobyevSergey L.<p>MD, Cand. Sci. (Med.)</p>ncmd@ncmd.ruhttps://orcid.org/0000-0002-7817-9069Clinical Rheumatology Hospital No. 25North-Western State Medical University named after I.I. MechnikovNorth-Western District Scientific and Clinical Center named after L.G. Sokolov Federal Medical and Biological AgencySaint Petersburg State UniversityMariinsky HospitalNational Center for Clinical Morphological Diagnostics20012023144931002610202220112022Copyright © 2022, Mazurov V.I., Gaidukova I.Z., Nochvay E.E., Petrova M.S., Inamova O.V., Mazurenko S.O., Petrova Y.A., Bychkova A.S., Vorobyev S.L.2022<p>Disseminated seronegative echinococcosis, occurring with damage to soft tissues, bones and joints, is a rare variant of the course of helminthiasis, often associated with diagnostic difficulties, a high probability of complications and difficult treatment.</p>
<p>This article presents a case of disseminated seronegative echinococcosis, clinically and laboratory simulating a severe form of WeberChristian panniculitis complicated by sepsis. The advantages and disadvantages of serological and morphological studies in the verification of disseminated echinococcosis are discussed, as well as the feasibility of using repeated histological studies in cases of echinococcosis under the masks of rheumatic diseases.</p>echinococcosishydatid cystsepsisWeber–Christian disease panniculitispancreatic panniculitisэхинококкозгидатидысколексысепсиспанникулит Вебера – Крисченапанникулит, ассоциированный с панкреатитом[Moro P, Schantz PM. Echinococcosis: a review. Int J Infect Dis. 2009;13(2):125–133. DOI: 10.1016/j.ijid.2008.03.037][McManus DP, Zhang W, Li J, Bartley PB. Echinococcosis. Lancet. 2003;362(9392):1295–1304. DOI: 10.1016/S0140-6736(03)14573-4][Sadjjadi SM. Present situation of echinococcosis in the Middle East and Arabic North Africa. Parasitol Int. 2006;55:197–202. DOI: 10.1016/j.parint.2005.11.030][Tekinbas C, Turedi S, Gunduz A, Erol MM. Hydatid cyst disease of the lung as an unusual cause of massive hemoptysis: a case report. J Med Case Rep. 2009;3:21. DOI: 10.1186/1752-1947-3-21][Sarkar M, Pathania R, Jhobta A, et al. Cystic pulmonary hydatidosis. Lung India. 2016;33(2):179–191. DOI: 10.4103/0970-2113.177449][Engström ELS, Salih GN, Wiese L. Seronegative, complicated hydatid cyst of the lung: A case report. Respir Med Case Rep. 2017;21:96–98. DOI: 10.1016/j.rmcr.2017.04.005][Sarkari B, Rezaei Z. Immunodiagnosis of human hydatid disease: Where do we stand? World J Methodol. 2015;5(4):185–195. DOI: 10.5662/wjm.v5.i4.185][Biava MF, Dao A, Fortier B. Laboratory diagnosis of cystic hydatic disease. World J Surg. 2001;25(1):10–14. DOI: 10.1007/s002680020002][Force L, Torres JM, Carrillo A, Buscà J. Evaluation of eight serological tests in the diagnosis of human echinococcosis and follow-up. Clin Infect Dis. 1992;15(3):473–480. DOI: 10.1093/clind/15.3.473][Singh U, Kumar S, Gour H, et al. Complicated hydatid cyst and “air bubble” sign: a stepping-stone to correct diagnosis. Am J Case Rep. 2015;16:20–24. DOI: 10.12659/AJCR.892621][Beggs I. The radiology of hydatid disease. AJR Am J Roentgenol. 1985;145(3):639–648. DOI: 10.2214/ajr.145.3.639][von Sinner WN. New diagnostic signs in hydatid disease; radiography, ultrasound, CT and MRI correlated to pathology. Eur J Radiol. 1991;12(2):150–159. DOI: 10.1016/0720-048x(91)90119-g][Kuzucu A, Soysal O, Ozgel M, Yologlu S. Complicated hydatid cysts of the lung: clinical and therapeutic issues. Ann Thorac Surg. 2004;77(4):1200–1204. DOI: 10.1016/j.athoracsur.2003.09.046][Ramos G, Orduña A, García-Yuste M. Hydatid cyst of the lung: diagnosis and treatment. World J Surg. 2001;25(1):46–57. DOI: 10.1007/s002680020007][Turgut AT, Altin L, Topçu S, et al. Unusual imaging characteristics of complicated hydatid disease. Eur J Radiol. 2007;63(1):84–93. DOI: 10.1016/j.ejrad.2007.01.001][von Sinner WN. Radiographic, CT and MRI spectrum of hydatid disease of the chest: a pictorial essay. Eur Radiol. 1993;3(1):62–70. DOI: 10.1007/bf00173526][Anadol D, Ozçelik U, Kiper N, Göçmen A. Treatment of hydatid disease. Paediatr Drugs. 2001;3(2):123–135. DOI: 10.2165/00128072-200103020-00005]