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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">HERALD of North-Western State Medical University named after I.I. Mechnikov</journal-id><journal-title-group><journal-title xml:lang="en">HERALD of North-Western State Medical University named after I.I. Mechnikov</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Северо-Западного государственного медицинского университета им. И.И. Мечникова</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2618-7116</issn><issn publication-format="electronic">2618-9704</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">625416</article-id><article-id pub-id-type="doi">10.17816/mechnikov625416</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original study article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Surgical tactics for Crohn’s disease complicated by intestinal bleeding</article-title><trans-title-group xml:lang="ru"><trans-title>Хирургическая тактика при болезни Крона, осложненной кишечным кровотечением</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title/></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2452-0321</contrib-id><contrib-id contrib-id-type="spin">5903-0288</contrib-id><name-alternatives><name xml:lang="en"><surname>Trunin</surname><given-names>Evgeniy M.</given-names></name><name xml:lang="ru"><surname>Трунин</surname><given-names>Евгений Михайлович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор</p></bio><email>Evgeniy.Trunin@szgmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-5578-3913</contrib-id><contrib-id contrib-id-type="spin">8151-2024</contrib-id><name-alternatives><name xml:lang="en"><surname>Petrov</surname><given-names>Sergey V.</given-names></name><name xml:lang="ru"><surname>Петров</surname><given-names>Сергей Викторович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор</p></bio><email>petrovsv@eliz-spb.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1563-2126</contrib-id><name-alternatives><name xml:lang="en"><surname>Shchegolev</surname><given-names>Andrey I.</given-names></name><name xml:lang="ru"><surname>Щеголев</surname><given-names>Андрей Игоревич</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><email>cionic@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1527-3848</contrib-id><name-alternatives><name xml:lang="en"><surname>Kozobin</surname><given-names>Aleksandr A.</given-names></name><name xml:lang="ru"><surname>Козобин</surname><given-names>Александр Анатольевич</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><email>akozobin@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9599-3935</contrib-id><name-alternatives><name xml:lang="en"><surname>Tatarkin</surname><given-names>Vladislav V.</given-names></name><name xml:lang="ru"><surname>Татаркин</surname><given-names>Владислав Владимирович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><email>Vladislav.Tatarkin@szgmu.ru</email></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1803-5298</contrib-id><name-alternatives><name xml:lang="en"><surname>Koshcheev</surname><given-names>Anton V.</given-names></name><name xml:lang="ru"><surname>Кощеев</surname><given-names>Антон Викторович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><email>kosheev70@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1096-835X</contrib-id><name-alternatives><name xml:lang="en"><surname>Baymakov</surname><given-names>Sayfiddin R.</given-names></name><name xml:lang="ru"><surname>Баймаков</surname><given-names>Сайфиддин Рисбоевич</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор</p></bio><email>bsayfiddin@yahoo.com</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-7661-9253</contrib-id><name-alternatives><name xml:lang="en"><surname>Tagayev</surname><given-names>Sherkabul B.</given-names></name><name xml:lang="ru"><surname>Тагаев</surname><given-names>Шеркабул Байкабулович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, доцент</p></bio><email>tagayev.66@mail.ru</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6767-7241</contrib-id><name-alternatives><name xml:lang="en"><surname>Pulatov</surname><given-names>Mirkhokim M.</given-names></name><name xml:lang="ru"><surname>Пулатов</surname><given-names>Мирхоким Мирсобитович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, доцент</p></bio><email>mir181164@gmail.com</email><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">North-Western State Medical University named after I.I. Mechnikov</institution></aff><aff><institution xml:lang="ru">Северо-Западный государственный медицинский университет им. И.И. Мечникова</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">City Hospital of the Holy Martyr Elizabeth</institution></aff><aff><institution xml:lang="ru">Елизаветинская больница</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">City Hospital of the Holy Martyr Elizabeth</institution></aff><aff><institution xml:lang="ru">Елизаветинская больница</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Tashkent State Dental Institute</institution></aff><aff><institution xml:lang="ru">Ташкентский государственный стоматологический институт</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-03-28" publication-format="electronic"><day>28</day><month>03</month><year>2024</year></pub-date><volume>16</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>71</fpage><lpage>77</lpage><history><date date-type="received" iso-8601-date="2023-12-30"><day>30</day><month>12</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2024-02-19"><day>19</day><month>02</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2024,</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/vszgmu/article/view/625416">https://journals.eco-vector.com/vszgmu/article/view/625416</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND</bold>: The course of Crohn’s disease often leads to complications requiring surgical treatment. One of the most serious complications of Crohn’s disease is intestinal bleeding.</p> <p><bold>AIM</bold><bold>:</bold> To determine the most optimal timing and extent of surgical treatment in patients with Crohn’s disease complicated by intestinal bleeding when conservative therapy is ineffective.</p> <p><bold>MATERIALS</bold><bold> </bold><bold>AND</bold><bold> </bold><bold>METHODS</bold><bold>:</bold> The article presents the experience of treating patients with Crohn’s disease complicated by intestinal bleeding at the Center for Gastroenterology and Oncopreventology of the Elizabeth Hospital (Russia) and the Republican Scientific Center of Coloproctology (Uzbekistan).</p> <p><bold>RESULTS</bold><bold>:</bold> Despite the possibilities of conservative treatment, in 33% of cases the therapy was ineffective and required urgent surgical intervention. The degree of intervention was selected individually based on multivariate analysis.</p> <p><bold>CONCLUSIONS</bold><bold>:</bold> Intestinal bleeding is a life-threatening complication of Crohn’s disease, causing the need for surgical intervention in almost a third of cases. Crohn’s disease is characterized by various damage to the gastrointestinal tract, which require multiple options for resective surgery on the small and large intestines, as well as an individual approach to the degree of intervention. The use of modern methods of complex conservative therapy for Crohn’s disease can reduce the risk of complications and reduce the amount of surgical intervention.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> Течение болезни Крона часто приводит к осложнениям с необходимостью хирургического лечения. Одним из наиболее грозных осложнений является кишечное кровотечение.</p> <p><bold>Цель исследования — </bold>определить наиболее оптимальные сроки и объем хирургического лечения у пациентов с болезнью Крона, осложненной кишечным кровотечением, при неэффективности консервативной терапии.</p> <p><bold>Материалы и методы.</bold> В статье представлен опыт лечения пациентов с болезнью Крона, осложненной кишечным кровотечением, в Центре гастроэнтерологии и онкопревентологии Елизаветинской больницы (Россия) и Республиканском научном центре колопроктологии (Узбекистан).</p> <p><bold>Результаты.</bold> Несмотря на возможности консервативного лечения, в 33 % наблюдений терапия была не эффективной, и потребовалось срочное хирургическое вмешательство. Объем вмешательства выбирали индивидуально на основе многофакторного анализа.</p> <p><bold>Заключение.</bold> Кишечное кровотечение является жизнеугрожающим осложнением болезни Крона, вызывающим почти в трети наблюдений необходимость хирургического вмешательства. Болезнь Крона характеризуется вариабельностью поражения органов желудочно-кишечного тракта, что обуславливает различные варианты резекционных вмешательств на тонкой и толстой кишках, а также индивидуальный подход в выборе объема операции. Применение современных методов комплексной консервативной терапии болезни Крона позволяет снизить риск развития осложнений и уменьшить объем оперативного вмешательства.</p></trans-abstract><trans-abstract xml:lang="zh"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>complication of Crohn’s disease</kwd><kwd>intestinal bleeding</kwd><kwd>surgical treatment of Crohn’s disease</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>осложнение болезни Крона</kwd><kwd>кишечное кровотечение</kwd><kwd>хирургическое лечение болезни Крона</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Sandborn WJ, Feagan BG, Hanauer SB, et al. A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn’s disease. 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