HERALD of North-Western State Medical University named after I.I. MechnikovHERALD of North-Western State Medical University named after I.I. MechnikovВестник Северо-Западного государственного медицинского университета им. И.И. Мечникова2618-71162618-9704Eco-Vector63367810.17816/mechnikov633678SRMMWTCase reportКлинический случайResearch ArticleMetastases of Melanoma of the Skin in the Gallbladder (A Rare Clinical Case)Метастаз меланомы кожи в желчном пузыре (редкое клиническое наблюдение)https://orcid.org/0000-0002-2128-86516396-4386KurkovAlexey А.КурковАлексей Андреевич
Russian Federation

MD, Cand. Sci. (Medicine)

канд. мед. наук

dok.kurkov@gmail.comhttps://orcid.org/0000-0002-4556-49135571-8893SiguaBadri V.СигуаБадри Валериевич
Russian Federation

MD, Dr. Sci. (Medicine)

д-р мед. наук

dr.sigua@gmail.comhttps://orcid.org/0009-0001-1362-7916KleymyukSofya V.КлеймюкСофья Викторовна
Russian Federation

MD

sofikleim@gmail.comhttps://orcid.org/0000-0002-9569-84857376-9672LatariaElgudzha L.ЛатарияЭлгуджа Лаврентьевич
Russian Federation

MD, Cand. Sci. (Medicine), Assistant Professor

канд. мед. наук, доцент

Elguja.Lataria@szgmu.ruhttps://orcid.org/0000-0002-6299-28568205-6112BelyaevaAnna V.БеляеваАнна Валерьевна
Russian Federation

MD, Cand. Sci. (Medicine)

канд. мед. наук

Anna.Belyaeva@szgmu.ruhttps://orcid.org/0000-0002-9590-66786448-9110VinnichukSergey А.ВинничукСергей Анатольевич
Russian Federation

MD, Cand. Sci. (Medicine)

канд. мед. наук

s.a.vinnichuk@gmail.comhttps://orcid.org/0000-0003-2329-00235398-3460ZemlianoiViacheslav P.ЗемлянойВячеслав Петрович
Russian Federation

MD, Dr. Sci. (Medicine), Professor, Honored Doctor of the Russian Federation

д-р мед. наук, профессор, заслуженный врач РФ

zeml.spb@mail.ruNorth-Western State Medical University named after I.I. MechnikovСеверо-Западный государственный медицинский университет им. И.И. Мечникова13052025171981052306202409092024Copyright ©; 2025, Eco-VectorCopyright ©; 2025, Эко-ВекторCopyright ©; 2025,2025Eco-VectorЭко-Векторhttps://journals.eco-vector.com/vszgmu/article/view/633678

Melanoma is a highly malignant tumor with a tendency to early and aggressive metastasis. Melanoma metastases in the gallbladder are found in 20% of patients with melanoma according to autopsy data, however, intravital detection of metastases is a rare case in clinical practice, which is associated with the asymptomatic course of the disease in 85% of patients. The prognosis for detecting a secondary lesion of the gallbladder in melanoma is extremely unfavorable due to late diagnosis and the high probability of concomitant metastasis. The key to prolonging survival of these patients is early detection of metastases and initiation of immediate and radical treatment. The presented clinical observation demonstrates an example of identifying metastasis of skin melanoma to the gallbladder after a two-year remission of the disease. As in most cases, the course of the disease was asymptomatic, and the reason for planned surgical treatment was the formation of the gallbladder, presumably a polyp or a conglomerate of stones, which were identified by computed tomography. Metastasis of skin melanoma to the gallbladder was confirmed by pathohistological examination of the surgical material. In patients with a history of melanoma, a thorough examination of the hepatobiliary tract should be carried out using the most informative diagnostic techniques for the timely detection of metastatic foci.

Меланома — высокозлокачественная опухоль со склонностью к раннему и агрессивному метастазированию. Метастазы меланомы в желчном пузыре обнаруживают у 20% пациентов с меланомой по данным аутопсии, однако прижизненное выявление метастазов — единичные случаи в клинической практике, что связано с бессимптомным течением заболевания у 85% пациентов. Прогноз при выявлении вторичного поражения желчного пузыря при меланоме крайне неблагоприятный из-за поздней диагностики и высокой вероятности сопутствующего метастазирования. Ключом к продлению выживаемости таких пациентов является раннее выявление метастазов и начало немедленного и радикального лечения. В представленном клиническом наблюдении продемонстрирован пример выявления метастаза меланомы кожи в желчном пузыре после двухлетней ремиссии заболевания. Как и в большинстве случаев, течение заболевания протекало бессимптомно, а поводом для оперативного лечения в плановом порядке стало образование в желчном пузыре (предположительно, полип или конгломерат конкрементов), обнаруженное при компьютерной томографии. Метастаз меланомы кожи подтвержден при патогистологическом исследовании операционного материала. У пациентов с меланомой в анамнезе следует тщательно обследовать гепатобилиарный тракт с применением наиболее информативных диагностических методик для своевременного обнаружения метастатических очагов.

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