HERALD of North-Western State Medical University named after I.I. MechnikovHERALD of North-Western State Medical University named after I.I. Mechnikov2618-71162618-9704Eco-Vector849410.17816/mechnikov201572108-113Research ArticleFIBROBLAST GROWTH FACTOR (FGF) 21 AT MULTIMORBID CARDIOVASCULAR PATHOLOGY WITH ANXIETY AND DEPRESSIVE DISORDERS IN YOUNG AND MIDDLE-AGED MENPartsernyakA S-ProshyaiG A-PartsernyakS A-AflitonovM A-MironenkoA N-TopanovaA A-Military Medical Academy named after S.M. KirovCity hospital №15, Saint-Petersburg, RussiaNorthwestern State Medical university named after I.I. Mechnikov150620157210811330032018Copyright © 2015, Partsernyak A.S., Proshyai G.A., Partsernyak S.A., Aflitonov M.A., Mironenko A.N., Topanova A.A.2015Evaluate (FGF) 21 at multimorbid cardiovascular pathology (MCVP) (coronary artery disease (CAd), hypertension, metabolic syndrome (MS)) with non-psychotic mental disorders (NPMd) anxiety/ depressive type. Identify the effectiveness of visual-auditory effects in the treatment of these pathologies. design and methods: The study included 70 men (mean age 37,46±6,74) with MCVP divided into 4 groups by simple random sampling, and 20 healthy men (mean age 38,3±6,73 g). Patients in Group 1 (n = 22) received standard therapy CAd, hypertension and NPMd, in group 2 (n = 25) standard therapy CAd, hypertension, NPMd and visual-auditory correction. Patients of group 3 (n =23) received standard therapy CAd, hypertension, NPMd, visual-auditory correction and psychotherapy. used in the study: complex psychological test methods and laboratory-instrumental evaluation of the cardiovascular system. definition of FGF21 performed by ELISA using kits BCM diagnostics SK00145-01 (BCM diagnostics, uSA). Results: Identified a two-fold increase in the concentration of serum FGF 21 after the course of standard therapy in the first group. In the other groups showed a statistically significant decrease FGF21 after psychopharmacological and visual-auditory therapy. In all groups after treatment was observed significantly change the type of NdP «severe depression»,«clinical anxiety» to «mild depression»; «subclinical anxiety» (p 0,001). Conclusions: FGF21 may be important biomarker for early diagnosis of metabolic abnormalities in this pathology. Results indicate benefits of combined therapy MCVP with the use of psychotropic drugs and visual-auditory correction method. Choose the method of complex treatment given the side effects of pharmacological agents.multimorbid cardiovascular pathologyfibroblast growth factor 21 (FGF21)anxiety and depressive disordersполиморбидная сердечно-сосудистая патологияфактора роста фибробластов 21 (FGF21)тревожно- депрессивные расстройства[Оганов Р.Г., Ольбинская Л.И., Смулевич А.Б., Дробижев М.Ю., Шальнова С.А., Погосова Г.В. Депрессии и расстройства депрессивного спектра в общемедицинской практике. Результаты программы КОМПАС // Кардиология. - 2004. - № 1. - P. 48-54.][Watanabe H., Shiomi H., Nakatsuma K., Morimoto T., Taniguchi T., Furukawa Y. et al. Clinical Efficacy of Thrombus Aspiration on 5-Year Clinical Outcomes in Patients With ST-Segment Elevation Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention // Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease. - 2015. - Vol.4. - № 6. - P. 35-40.][Sepanlou S.G., Sharafkhah M., Poustchi H., Malekzadeh M.M., Etemadi A., Khademi H. Hypertension and mortality in the Golestan Cohort Study: A prospective study of 50 000 adults in Iran // Journal of Human Hypertension. - 2015. - Vol. 6. - № 11. - P. 43-54.][Шурыгин М.Г., Шурыгина И.А. Фактор роста фибробластов как стимулятор ангиогенеза при инфаркте миокарда // Бюллетень ВСНЦ СО РАМН. - 2010. - № 6. - Т. 30. - С. 89-92.][Dutchak P.A., Katafuchi T., Bookout A.L., Choi J.H., Yu R.T., Mangelsdorf D.J. et al. Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones // Cell. - 2012. - Vol.3. - № 148. - P. 556- 67.][Fisher F.M., Chui P.C., Antonellis P.J., Bina H.A., Kharitonenkov A., Flier J.S. et al. Obesity is a fibroblast growth factor 21 (FGF21)-resistant state // Diabetes. - 2010. - Vol. 59. - № 11. - P. 81-9.][Woo Y. C., Xu Aimin, Wang Yu, Lam Karen S. L. Fibroblast Growth Factor 21 as an Emerging Metabolic Regulator // Clin Endocrinol. - 2013. - Vol. 78. - № 4. - P. 489 - 496.][Anderson G., Maes M. Bipolar disorder: role of immune-inflammatory cytokines, oxidative and nitrosative stress and tryptophan catabolites. // Current Psychiatry Reports. -2015. - Vol. 17. - № 2. - P. 8.]