Studying zonulin levels in patients with inflammatory bowel disease and peripheral arthritis
- Authors: Khusainova G.M.1, Nesmeyanova O.B.2, Dolgushina A.I.1, Abramovskikh O.S.1, Genkel V.V.1, Nikushkina K.V.1
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Affiliations:
- South-Ural State Medical University
- Chelyabinsk Regional Clinical Hospital
- Issue: Vol 15, No 3 (2023)
- Pages: 33-40
- Section: Original research
- Submitted: 17.09.2023
- Accepted: 24.10.2023
- Published: 14.12.2023
- URL: https://journals.eco-vector.com/vszgmu/article/view/582014
- DOI: https://doi.org/10.17816/mechnikov582014
- ID: 582014
Cite item
Abstract
BACKGROUND: Currently, disruption of the barrier function of the intestinal mucosa is considered one of the key mechanisms in the pathogenesis of extraintestinal manifestations of inflammatory bowel diseases, especially damage to the musculoskeletal system.
AIM: To study the relationship between the level of zonulin in blood serum and the parameters of the immune status in patients with inflammatory bowel diseases in combination with peripheral arthritis.
MATERIALS AND METHODS: 97 patients with ulcerative colitis and Crohn’s disease have been examined, with peripheral arthritis verified in 47 patients; the control group included 50 patients without peripheral arthritis. Zonulin, tumor necrosis factor α, interleukin-1β, -10, -17A, -23 were determined in blood serum using standard kits for direct enzyme immunoassay.
RESULTS: Patients with peripheral arthritis were younger with an earlier onset of inflammatory bowel diseases (p < 0.001). When assessing the concentration of serum zonulin in the patients with and without arthritis, no significant differences have been found. In the patients with peripheral arthritis, zonulin concentration directly correlated with the level of interleukin-17A (r = 0.323; p = 0.039), interleukin-23 (r = 0.321; p = 0.041).
CONCLUSIONS: According to the data obtained, the use of zonulin as a marker of peripheral arthritis in inflammatory bowel diseases is not recommended. Nevertheless, the correlation of zonulin and the concentrations of interleukin-17А and -23 demonstrates its role in the regulation of mucosal immunity in the development of extraintestinal manifestations of inflammatory bowel diseases.
Full Text
About the authors
Guzel M. Khusainova
South-Ural State Medical University
Author for correspondence.
Email: husainovagm@yandex.ru
ORCID iD: 0000-0001-5954-3112
SPIN-code: 9660-5293
MD, Assistant
Russian Federation, ChelyabinskOlga B. Nesmeyanova
Chelyabinsk Regional Clinical Hospital
Email: olganesmeyanova@mail.ru
MD, Cand. Sci. (Med.)
Russian Federation, ChelyabinskAnastasia I. Dolgushina
South-Ural State Medical University
Email: dolgushinaai@yandex.ru
ORCID iD: 0000-0003-2569-1699
MD, Dr. Sci. (Med.), Professor
Russian Federation, ChelyabinskOlga S. Abramovskikh
South-Ural State Medical University
Email: abramoschel@mail.ru
ORCID iD: 0000-0001-7086-5657
SPIN-code: 6330-3570
MD, Dr. Sci. (Med.), Professor
Russian Federation, ChelyabinskVadim V. Genkel
South-Ural State Medical University
Email: henkel-07@mail.ru
ORCID iD: 0000-0001-5902-3803
SPIN-code: 2519-6100
MD, Cand. Sci. (Med.), Assistant Professor
Russian Federation, ChelyabinskKarina V. Nikushkina
South-Ural State Medical University
Email: knikushkina81@gmail.com
ORCID iD: 0000-0002-3900-9278
SPIN-code: 4216-6139
MD, Cand. Sci. (Med.)
Russian Federation, ChelyabinskReferences
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