ROLE OF THE COMPLEMENT AND CYTOKINES IN THE EARLYDIAGNOSIS OF MULTIPLE SCLEROSIS



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Abstract

In the article are presented the results of the study of blood and cerebrospinal fluid for cytokines and the complement proteins in 22 patients with clinically isolated syndrome in accordance with the subsequent development of the disease. It is find out the differences between the concentration of some complement proteins in patients with the developed during the observation the definite multiple scle- rosis in comparison with the patients with clinically isolated syndrome, and cytokine status. The de- termination of immunological predictors of multiple sclerosis development may help to understand the dynamics of pathological process and to start the early treatment.

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About the authors

S V Lobzin

North-West State Medical university named after I.I. Mechnikov

N B Serebryanaya

North-West State Medical university named after I.I. Mechnikov

A M Ischenko

North-West State Medical university named after I.I. Mechnikov

V I Golovkin

North-West State Medical university named after I.I. Mechnikov

M V Fomintseva

North-West State Medical university named after I.I. Mechnikov

I I Kula

North-West State Medical university named after I.I. Mechnikov

References

  1. Завалишин И.А., Головкин В.И. Рассеянный склероз. Избранные вопросы теории и практик. - М.: МИА, 2000. - 639 с.
  2. Завалишин И.А., Переседова А.В., Стойда Н.И., Гурьянова О.Е., Арзуманян Н.Ш., Алексеева Н.С., Елисеева Д.Д., Гулевская Т.С., Брюхов В.В. Диагностика и лечение рассеянного склероза// Журнал неврологии и психиатрии. - 2011. - № 6. - С. 89-96.
  3. Bielekova, B. Development of biomarkers in multiple sclerosis / B.Bielekova, R.Martin. // Brain. - 2004. - Vol.127. - N.7. - P.1463-1478.
  4. Bitsch, A. Tumour necrosis factor α mRNA expression in early multiple sclerosis lesions: correlation with demyelinating activity and oligodendrocyte pathology / A. Bitsch, T. Kuhlmann, C. Da Costa, et al. // Glia. - 2000. - Vol.29. - N.4. - P. 366-375.
  5. Boos, L. Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis. L.Boos, I.L.Campbell, R.Ames, R.A. Wetsel, S.R. Barnum. // J. Immunol. - 2004. - Vol.173. - N.7. - P.4708-4714.
  6. Huang, W.X. Cytokine analysis in multiple sclerosis by competitive RT-PCR: a decreased expression of IL-10 and an increased expression of TNF-α in chronic progression / W.X.Huang, P. Huang, H. Link, J. Hillert // Mult. Scler. - 1999. - Vol.5. - N.5. - P. 342-348.
  7. Navikas, V. Increased mRNA expression of IL-10 in mononuclear cells in multiple sclerosis and optic neuritis / V. Navikas, J.Link , W.Palasik, M.Soderstrom, et al. // Scand. J. Immunol. - 1995. - Vol.41. - N.2. - P. 171-178.
  8. Ozenci, V. Multiple sclerosis is associated with an imbalance between tumour necrosis factor-α (TNF-α)- and IL-10-secreting blood cells that is corrected by interferon-β (IFN-β) treatment / V. Ozenci, M. Kouwenhoven, Y.M. Huang, et al. // Clin. Exp. Immunol. - 2000. - Vol.120. - N.1. - P. 147-153.
  9. Polman, C.H. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald Criteria. / C.H. Polman, S.C. Reingold, B. Banwell, et. al.// Ann Neurol. - 2011. - Vol.69. - N.2. - P. 292-302.
  10. Scolding, N.J. Normal rat serum cytotoxicity against syngeneic oligodendrocytes. Complement activation and attack in the absence of anti-myelin antibodies / N.J. Scolding, B.P. Morgan, A. Houston, et al. // J. Neurol. Sci. - 1989. - Vol.89. - N.2-3. - P. 289-300.
  11. Sospedra, M. Immunology of Multiple sclerosis. / M. Sospedra, R. Martin // Annu. Rev. Immunol. - 2005. - Vol. 23. - P. 683-747.

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Copyright (c) 2015 Lobzin S.V., Serebryanaya N.B., Ischenko A.M., Golovkin V.I., Fomintseva M.V., Kula I.I.

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