Local cytokine status of experimental animalsat experimental intraocular implantationof titanium nickelide
- Authors: Steblyuk A.N.1, Kolesnikova N.V.2, Gyunter V.E.3
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Affiliations:
- S. N. Fyodorov Eye Microsurgery Complex, Krasnodar Branch
- Kuban State Medical University
- Tomsk State University
- Issue: Vol 6, No 4 (2013)
- Pages: 4-8
- Section: Articles
- URL: https://journals.eco-vector.com/ov/article/view/357
- DOI: https://doi.org/10.17816/OV201344-8
- ID: 357
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Full Text
Abstract
An assessment of the level of pro- (IL1β, FNOα, IL2) and anti-inflammatory (IL10) cytokines in the intraocular fluid of experimental animals at 3, 7 and 30 days after experimental intraocular implantation of porous titanium nickelide TN-10 was carried out. It was found that the implantation of porous titanium nickelide as drainage material does not impact the pro-inflammatory and anti-inflammatory cytokines’ local balance. It does cause an increase of IL1β, IL2 and IL10 production to the end of the first week of monitoring as well as a substantial limitation of anti-inflammatory FNOα synthesis. However at the end of the 30 day monitoring period, local IL1β and IL10 concentrations corresponded to those of control animals. At the same time, of some significance are obtained data upon a modulation of a caused by the surgical procedure disbalance in the system of local pro- and anti-inflammatory cytokines which is observed at the titanium nickelide TN-10 intraocular implantation.
About the authors
Aleksey Nikolayevich Steblyuk
S. N. Fyodorov Eye Microsurgery Complex, Krasnodar Branch
Email: okocntr@mail.kuban.ru
MD, PhD, ophthalmologist
Natalya Vladislavovna Kolesnikova
Kuban State Medical University
Email: troickaya@rambler.ru
doctor of biology science, professor
Viktor Eduardovich Gyunter
Tomsk State University
Email: guntsme@elefot.tsu.ru
doctor of technical science, professor
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