Morphological study of idiopathic epiretinal membranes and their cytokine profile

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Abstract


The article presents comparative morphological analysis and assessment of response to antigens of fibronectin, laminin, glial fibrillary acidic protein (GFAP) in idiopathic epiretinal membranes (iERM). Authors found a comparable positive iERM reaction to fibronectin and GFAP, which indicates the involvement of these cytokines in the development and progression of the posterior segment neurodegenerative process. Cellular elements in the vitreous gel responsible for iERM formation were fibroblasts, myofibroblasts, hyalocytes, and retinal radial glial cells. Retinal radial glial cells play the main role in the recurrent iERM formation.

Conclusion. Due to its hemodynamic, nootropic, neurotrophic action, the investigated bioregulatory complex increases the optic nerve tolerance to the stress effect of IOP, SBP, and DBP asynchronous fluctuations, and improves the ocular blood perfusion.


Ural R Altynbaev

uralaltynbaev@rambler.ru
OAO “Tatneft”
Russian Federation

MD, PhD. Ophthalmology Department, Medical Unit

Anna I Lebedeva

morpholetter@yandex.ru
Federal State Institution “All-Russian Eye and Plastic Surgery Center”
Russian Federation

PhD, head of histology and immunohistochemistry laboratory. Morphology Department

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