The Second Language of DNA
- 作者: Orlov M.A1
-
隶属关系:
- Institute of Cell Biophysics, Pushchino Center for Biological Research, RAS
- 期: 编号 9 (2021)
- 页面: 3-12
- 栏目: Articles
- URL: https://journals.eco-vector.com/0032-874X/article/view/628045
- DOI: https://doi.org/10.7868/S0032874X21090015
- ID: 628045
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详细
DNA is crucial to life. This molecule rests at the heart of a cell nucleus, stands in between most important metabolic pathways, and provides the basis for genetic information flow. However does it really just rest? Is that big and early invention of evolution limited to the inert function of information storage? To address this we tackle several aspects of DNA structure. Each of them may become crucial when the molecule changes its role — when it serves as a blueprint for copying, a site for precise binding of proteins, or is involved in complex and dynamic interactions with them. We focus on promoters which initiate the process of transcription, i.e. the “rewriting” of DNA into RNA. Our setting is the tiny genome of bacteriophage T7 and its petite, very similar yet very distinct promoters.
作者简介
M. Orlov
Institute of Cell Biophysics, Pushchino Center for Biological Research, RAS
Email: orlovmikhailanat@gmail.com
Pushchino, Russia
参考
- Орлов М.А., Рясик А.А., Сорокин А.А. Дестабилизация дуплекса ДНК активно реплицирующихся промоторов бактериофагов группы Т7. Молекул. биол. 2018; 52(5): 793–800. doi: 10.1134/S0026898418050117.
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- Orlov M., Garanina I., Fisunov G.Y., Sorokin A. Comparative analysis of Mycoplasma gallisepticum vlhA promoters. Front. Genet. 2018; 9: 569. doi: 10.3389/fgene.2018.00569.
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- Orlov M.A., Sorokin A.A. DNA sequence, physics, and promoter function: Analysis of high-throughput data On T7 promoter variants activity. J. Bioinform. Comput. Biol. 2020; 18: 2040001. doi: 10.1142/S0219720020400016.
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