Autoimmune thyroiditis in a young child with Down’s syndrome
- Authors: Shitkovskaya E.1, Grishkevich N.1, Trofimenko V.1, Verkhorubova V.2, Dmitriev S.2, Strelnlkov G.2
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Affiliations:
- Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
- I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital Twenty
- Issue: Vol 30, No 8 (2019)
- Pages: 45-48
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/114016
- DOI: https://doi.org/10.29296/25877305-2019-08-10
- ID: 114016
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Abstract
The paper describes a clinical case of primary acquired hypothyroidism developed in the presence of autoimmune thyroiditis in a one year and two-month-old infant with Down’s syndrome.
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About the authors
E. Shitkovskaya
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
N. Grishkevich
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
V. Trofimenko
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
V. Verkhorubova
I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital Twenty
S. Dmitriev
I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital Twenty
G. Strelnlkov
I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital Twenty
References
- Gibson P., Newton R., Selby K. et al. Longitudinal study of thyroid function in Down’s syndrome in the first two decades // Arch. Dis. Child. - 2005; 90 (6): 574-8. doi: 10.1136/adc.2004.049536
- Downside up. Endokrinnye zabolevaniya pri sindrome Dauna (in Russ.)]. Доступно на / Available at: https://downsideup.org/ru [Accessed 20 January, 2019]
- Myslek-Prucnal M., Sadowska L., Gruna-Ozarowska A. The diagnostics and developmental stimulation of small children with 21 trisomy in compliance with thyroid function // Pediatr. Endocrinol. Diabetes Metab. - 2008; 14 (4): 243-7.
- Pierce M., La Franchi S., Pinter J. Characterization of Thyroid Abnormalities in a Large Cohort of Children with Down Syndrome // Horm. Res. Paediatr. - 2017; 87 (3): 170-8. doi: 10.1159/000457952.
- Аметов А.С. Избранные лекции по эндокринологии / М.: Медицинское информационное агентство, 2016; с. 152-4; 189-91
- Чубарова А.И., Семенова Н.А., Руянцева В.А. Патология щитовидной железы у детей с синдромом Дауна // Синдром Дауна XXI век. - 2010; 1 (4): 9-11
- Aversa T., Crisafulli G., Zirilli G. et al. Epidemiological and clinical aspects of autoimmune thyroid diseases in children with Down’s syndrome // Ital. J. Pediatr. - 2018; 44 (1): 39. doi: 10.1186/s13052-018-0478-9.
- Дедов И.И., Мельниченко Г.А. Рациональная фармакотерапия заболеваний эндокринной системы и нарушений обмена веществ / М.: Литтерра, 2006; с. 315-6
- Петунина Н.А., Мартиросян Н.С., Трухина Л.В. Дисфункция щитовидной железы и система кроветворения // Клини. и эксперим. тиреоидол. - 2011; 7 (4): 27-31
- Aversa T., Salerno M., Radetti G. et al. Peculiarities of presentation and evolution over time of Hashimoto’s thyroiditis in children and adolescents with Down’s syndrome // Hormones. - 2015; 14 (3): 410-6. DOI: 10.14310/ horm.2002.1574.
- Purdy I., Singh N., Brown W. et al. Revisiting early hypothyroidism screening in infants with Down syndrome // J. Perinatol. - 2014; 34 (12): 936-40. doi: 10.1038/jp.2014.116.
- Bull M. Committee on Genetics. Health supervision for children with Down syndrome // Pediatrics. - 2011; 128 (2): 393-406. doi: 10.1542/peds.2011-1605.
- Брука Ч.Г., Браун Р.С. Руководство по детской эндокринологии. Под ред. В.А. Петерковой / М.: ГЭОТАР-Медиа, 2009; с. 118-9
- Гарднер Д., Шобек Д. Базисная и клиническая эндокринология. Под ред. Г.А. Мельниченко / М.: Бином, 2015; с. 338-9
- Karlsson B., Gustafsson J., Hedov G. et al. Thyroid dysfunction in Down’s syndrome: relation to age and thyroid autoimmunity // Arch. Dis. Child. - 1998; 79 (3): 242-5.
- Pueschel S., Pezzullo J. Thyroid dysfunction in Down syndrome // Am. J. Dis. Child. - 1985; 139 (6): 636-9.
- Gimenez-Barcons M., Casteras A., del Pilar Armengol M. et al. Autoimmune predisposition in down syndrome may result from a partial central tolerance failure due to insufficient intrathymic expression of AIRE and peripheral antigens // J. Immunol. - 2014; 193: 3872-9. doi: 10.4049/jimmunol.1400223.
- Skogberg G., Lundberg V., Lindgren S. et al. Altered expression of utoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype // J. Immunol. - 2014; 193: 2187-95. DOI: 10.4049/ jimmunol.1400742.
- Ludgate M., Emerson C. Metamorphic thyroid autoimmunity // Thyroid. -2008; 18 (10): 1035-7. doi: 10.1089/thy.2008.1551.
- McLachlan S., Rapoport B. Thyrotropin-blocking autoantibodies and thyroid-stimulating autoantibodies: potential mechanisms involved in the pendulum swinging from hypothyroidism to hyperthyroidism or vice versa // Thyroid. - 2013; 23 (1): 14-24. doi: 10.1089/thy.2012.0374.
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